Mono-(2-ethylhexyl) phthalate-d4
Based on 1 publication(s) in Google Scholar
Mono-(2-ethylhexyl) phthalate-d4 is a deuterium labeled Mono-(2-ethylhexyl) phthalate (HY-W018392). Mono-(2-ethylhexyl) phthalate (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP). Mono-(2-ethylhexyl) phthalate can promote fatty acid synthesis in hepatocytes by regulating the expression of relevant genes and proteins, contributing to non-alcoholic fatty liver disease (NAFLD).
For research use only. We do not sell to patients.
- Purity: 99.71%
- CAS No.: 1276197-22-8
- Formula: C16H18D4O4
- Molecular Weight:282.37
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Mono-(2-ethylhexyl) phthalate-d4
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1276197-22-8
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Unlabeled Cas 4376-20-9
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Appearance Liquid (Density: 1.1±0.1 g/cm3)
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Molecular Weight 282.37
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Formula C16H18D4O4
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Color Colorless to off-white
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SMILES
CCCCC(CC)COC(C1=C(C([2H])=C([2H])C([2H])=C1[2H])C(O)=O)=O
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Synonyms
MEHP-d4; Phthalic acid mono-2-ethylhexyl ester-d4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Arch Toxicol
PBK modelling of phthalates and their metabolites and the application in next generation risk assessment. [Abstract]2026 Jun 27. PMID: 42363979
Solvent & Solubility
DMSO : 100 mg/mL (354.15 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246. [Content Brief]
[2]. Bai J, et al. Mono-2-ethylhexyl phthalate induces the expression of genes involved in fatty acid synthesis in HepG2 cells. Environ Toxicol Pharmacol. 2019 Jul;69:104-111. [Content Brief]
[3]. Tomita I, et al. Fetotoxic effects of mono-2-ethylhexyl phthalate (MEHP) in mice. Environ Health Perspect. 1986 Mar;65:249-54. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5415 mL | 17.7073 mL | 35.4145 mL | 88.5363 mL |
| 5 mM | 0.7083 mL | 3.5415 mL | 7.0829 mL | 17.7073 mL | |
| 10 mM | 0.3541 mL | 1.7707 mL | 3.5415 mL | 8.8536 mL | |
| 15 mM | 0.2361 mL | 1.1805 mL | 2.3610 mL | 5.9024 mL | |
| 20 mM | 0.1771 mL | 0.8854 mL | 1.7707 mL | 4.4268 mL | |
| 25 mM | 0.1417 mL | 0.7083 mL | 1.4166 mL | 3.5415 mL | |
| 30 mM | 0.1180 mL | 0.5902 mL | 1.1805 mL | 2.9512 mL | |
| 40 mM | 0.0885 mL | 0.4427 mL | 0.8854 mL | 2.2134 mL | |
| 50 mM | 0.0708 mL | 0.3541 mL | 0.7083 mL | 1.7707 mL | |
| 60 mM | 0.0590 mL | 0.2951 mL | 0.5902 mL | 1.4756 mL | |
| 80 mM | 0.0443 mL | 0.2213 mL | 0.4427 mL | 1.1067 mL | |
| 100 mM | 0.0354 mL | 0.1771 mL | 0.3541 mL | 0.8854 mL |
Mono-(2-ethylhexyl) phthalate-d4 Related Classifications
HY-W018392S Related Classifications
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