Moxaverine hydrochloride

Moxaverine hydrochloride (1.28 × 10⁻³ M; 50 μL/eye; topical ocular administration; ¹⁴C tracing; 30 and 120 min) distributes mainly in the conjunctiva, cornea and iris/ciliary body, and can penetrate into the retina in male Dutch-belted pigmented rabbits. Compared with intravenous administration, the plasma level after topical ocular administration is significantly lower, and the content in the retina continues to increase at 120 min^[5].
After intravenous administration to male Dutch-belted pigmented rabbits, moxaverine hydrochloride (1.28 × 10⁻³ M; i.v.; ¹⁴C tracing; 30 and 120 min) can penetrate into the retina, but its retinal content decreases at 120 min compared with that at 30 min; its scleral contents at both 30 and 120 min are lower than those after topical ocular administration^[5].
Moxaverine hydrochloride (50 μL/eye; topical ocular administration; ¹⁴C-moxaverine-HCl tracing; 30 and 120 min) distributes mainly in the conjunctiva, cornea and iris/ciliary body in male Dutch-belted pigmented rabbits, with no measurable levels detected in the lens; the concentration in the retina is comparable to that after intravenous administration at 30 min, and higher than that after intravenous administration at 120 min, while the plasma level after topical ocular administration is lower than that after intravenous administration^[2].