1163-37-7
1163-37-7
Chemical Structure
Moxaverine hydrochloride
- CAS No.: 1163-37-7
- Formula:C20H22ClNO2
- Molecular Weight:343.85
IUPAC Name: 1-benzyl-3-ethyl-6,7-dimethoxyisoquinoline hydrochloride
InChIKey: DULZSDGCXSLVAQ-UHFFFAOYSA-N
SMILES: COC1=CC(C=C(CC)N=C2CC3=CC=CC=C3)=C2C=C1OC.Cl
Biological Activity: Moxaverine hydrochloride is a phosphodiesterase (PDE) inhibitor. Moxaverine hydrochloride also interacts with calmodulin (calmodulin), thereby enhancing the inhibition of calmodulin-dependent PDE. Moxaverine hydrochloride can be used in studies related to microcirculation regulation and ocular tissue distribution[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Moxaverine hydrochloride | Moxaverine hydrochloride is a phosphodiesterase (PDE) inhibitor. Moxaverine hydrochloride also interacts with calmodulin (calmodulin), thereby enhancing the inhibition of calmodulin-dependent PDE. Moxaverine hydrochloride can be used in studies related to microcirculation regulation and ocular tissue distribution. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Schmid-Schönbein H, et al. Influence of moxaverine hydrochloride on membrane curvature and microsieve filterability of red cells after exposure to hyperosmolarity and lactacidosis. Arzneimittel-Forschung. 1988 May;38(5):710-6.
- [2]. Becker U, et al. Tissue Distribution and Relative Bioavailability of Ocularly–Administered Moxaverine–HCl. Investigative Ophthalmology & Visual Science. 2004;45:3959. ARVO Annual Meeting Abstract.
- [3]. Becker U, et al. A comparative evaluation of corneal epithelial cell cultures for assessing ocular permeability. Alternatives to laboratory animals : ATLA. 2008 Feb;36(1):33-44.
- [4]. Yu AK, et al. Rescue of cell death and inflammation of a mouse model of complex 1-mediated vision loss by repurposed drug molecules. Hum Mol Genet. 2017 Dec 15;26(24):4929-4936.
- [5]. Becker U, et al. Tissue distribution of moxaverine-hydrochloride in the rabbit eye and plasma. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 2005 Jun;21(3):210-6.
- [6]. Becker U. Examination of the penetration behavior of pharmaceutical drugs on the eye and set-up of an in vitro cell model for ocular drug delivery. Universität des Saarlandes. 2006.
