NaV1.2/1.6 channel blocker-1
Based on 1 Customer Validation
NaV1.2/1.6 channel blocker-1 is a potent NaV1.2/1.6 channel blocker, with IC50s of 9.8 and 24.4 μM for rNaV1.6 and hNaV1.2, respectively. NaV1.2/1.6 channel blocker-1 can be used for the research of generalized epilepsy.
For research use only. We do not sell to patients.
- CAS No.: 1199944-04-1
- Formula: C14H14N2OS
- Molecular Weight:258.34
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
rNaV1.6 9.8 μM (IC50) |
hNaV1.2 24.4 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
26.19 μM
Compound: MV1035
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Antiinvasive activity against human A549 cells assessed as reduction in cell invasion measured after 24 hrs using Diff-quick staining by light microscopy based Boyden chamber assay
Antiinvasive activity against human A549 cells assessed as reduction in cell invasion measured after 24 hrs using Diff-quick staining by light microscopy based Boyden chamber assay
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[PMID: 31937477] |
| NCI-H460 | IC50 |
10.12 μM
Compound: MV1035
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Antimigratory activity against human H460 cells assessed as inhibition of cell migration measured after 24 hrs by scratch wound healing assay
Antimigratory activity against human H460 cells assessed as inhibition of cell migration measured after 24 hrs by scratch wound healing assay
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[PMID: 31937477] |
| NCI-H460 | IC50 |
17.78 μM
Compound: MV1035
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Antiinvasive activity against human H460 cells assessed as reduction in cell invasion measured after 24 hrs using Diff-quick staining by light microscopy based Boyden chamber assay
Antiinvasive activity against human H460 cells assessed as reduction in cell invasion measured after 24 hrs using Diff-quick staining by light microscopy based Boyden chamber assay
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[PMID: 31937477] |
| U-87MG ATCC | IC50 |
11.02 μM
Compound: MV1035
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Antimigratory activity against human U87MG cells assessed as inhibition of cell migration measured after 6 hrs by scratch wound healing assay
Antimigratory activity against human U87MG cells assessed as inhibition of cell migration measured after 6 hrs by scratch wound healing assay
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[PMID: 31937477] |
| U-87MG ATCC | IC50 |
2.48 μM
Compound: MV1035
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Antiinvasive activity against human U87MG cells assessed as reduction in cell invasion measured after 24 hrs using Diff-quick staining by light microscopy based Boyden chamber assay
Antiinvasive activity against human U87MG cells assessed as reduction in cell invasion measured after 24 hrs using Diff-quick staining by light microscopy based Boyden chamber assay
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[PMID: 31937477] |
In Vitro
NaV1.2/1.6 channel blocker-1 (compound 13) (1-100 μM) blocks the NaV1.6 and NaV1.2 sodium currents by 48.5% and 34.0% in HEK 293 stably expressing human NaV1.2 and rat NaV1.6 isoforms, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1199944-04-1
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Appearance Solid
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Molecular Weight 258.34
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Formula C14H14N2OS
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Color White to off-white
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SMILES
S=C1OC2=CC=CC=C2C3=NC(C)=C(CCC)N13
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 12.5 mg/mL (48.39 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8709 mL | 19.3543 mL | 38.7087 mL | 96.7717 mL |
| 5 mM | 0.7742 mL | 3.8709 mL | 7.7417 mL | 19.3543 mL | |
| 10 mM | 0.3871 mL | 1.9354 mL | 3.8709 mL | 9.6772 mL | |
| 15 mM | 0.2581 mL | 1.2903 mL | 2.5806 mL | 6.4514 mL | |
| 20 mM | 0.1935 mL | 0.9677 mL | 1.9354 mL | 4.8386 mL | |
| 25 mM | 0.1548 mL | 0.7742 mL | 1.5483 mL | 3.8709 mL | |
| 30 mM | 0.1290 mL | 0.6451 mL | 1.2903 mL | 3.2257 mL | |
| 40 mM | 0.0968 mL | 0.4839 mL | 0.9677 mL | 2.4193 mL |
NaV1.2/1.6 channel blocker-1 Related Classifications
HY-152166 Related Classifications
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