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Cat. No.: HY-168561

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NLRP3-IN-58

NLRP3-IN-58 (Compound DS15) is an inhibitor for the activation of NLRP3 inflammasome with an IC₅₀ of 3.85 μM, and inhibits 33% IL-1β release at a concentration of 10 μM.

For research use only. We do not sell to patients.

CAS No.: 2956014-05-2
Formula: C₂₂H₁₈ClN₃O₃S
Molecular Weight:439.91

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

NLRP3-IN-58 Chemical Structure

CAS No.: 2956014-05-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

NLRP3-IN-58 (Compound DS15) is an inhibitor for the activation of NLRP3 inflammasome with an IC₅₀ of 3.85 μM, and inhibits 33% IL-1β release at a concentration of 10 μM^[1].

All NOD-like Receptor (NLR) Isoforms :

All Interleukin Related Isoforms :

Chemical Information

CAS No. 2956014-05-2
Molecular Weight 439.91
Formula C₂₂H₁₈ClN₃O₃S
SMILES

O=C(NC1=CC=CC(S(=O)(NC2=CC=CC=C2)=O)=C1)CC3=CNC4=CC(Cl)=CC=C34
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. El-Sayed S, et al., Virtual screening-led design of inhibitor scaffolds for the NLRP3 inflammasome. Bioorg Chem. 2024 Oct 22;153:107909. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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NLRP3-IN-58

All NOD-like Receptor (NLR) Isoforms

All Interleukin Related Isoforms

Biological Activity

Description

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

NLRP3-IN-58 Related Classifications

HY-168561 Related Classifications

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Keywords

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