Oxiran-2-ylmethanol (Synonyms: Glycidol)

Cat. No.: HY-Y1010 Purity: 99.95%: Data Sheet
COA

SDS
Handling Instructions
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Oxiran-2-ylmethanol (Glycidol) is an ester product. Oxiran-2-ylmethanol induces base pair point mutations in bacterial strains and structural chromosome aberrations in cultured cells. Oxiran-2-ylmethanol forms N-(2,3-dihydroxypropyl)valine hemoglobin adducts. Oxiran-2-ylmethanol acts as an animal carcinogen but does not significantly induce micronucleated immature erythrocytes in animal bone marrow. Oxiran-2-ylmethanol enables anionic polymerization to produce linear poly(glycidol). Oxiran-2-ylmethanol can be used for cancer-related research.

For research use only. We do not sell to patients.

Oxiran-2-ylmethanol Chemical Structure

CAS No. : 556-52-5

Size	Stock	Quantity
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Liquid
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	In-stock	Estimated Time of Arrival: December 31
100 g	In-stock	Estimated Time of Arrival: December 31
> 100 g	Get quote

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Other Forms of Oxiran-2-ylmethanol:

Oxiran-2-ylmethanol-d₅ In-stock
Oxiran-2-ylmethanol (Standard) Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Oxiran-2-ylmethanol (G) (0.31-5000 μg/plate; 48 h) induces dose-dependent reverse mutations in Salmonella typhimurium (TA98, TA100, TA1535, TA1537) and Escherichia coli (WP2uvrA) strains, with particularly strong activity in point mutation-detecting strains, in both the presence and absence of metabolic activation^[1].
Oxiran-2-ylmethanol induces structural chromosomal aberrations in cultured Chinese hamster lung (CHL/IU) cells under short-term (with and without metabolic activation) and continuous (24 h and 48 h) treatment conditions, with the highest aberration frequency reaching 93.5% at 300 μg/mL in 6 h treatment without metabolic activation^[1].
Oxiran-2-ylmethanol (125-250 μM; 1 h at 37 °C) forms N-(2,3-dihydroxypropyl)valine adducts with hemoglobin in fresh human whole blood with a second-order reaction rate constant of 19.2 pmol/g Hb per µMh^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Oxiran-2-ylmethanol (G) (50-200 mg/kg; p.o.; two doses separated by 24 h) produces a significant increase in MNIMEs in male ICR mice at 100 mg/kg, but no dose-dependent genotoxic response is observed across 50, 100, and 200 mg/kg doses^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

74.08

Formula

C₃H₆O₂

CAS No.

556-52-5

Appearance

Liquid (Density: 1.115 g/cm³)

Color

Colorless to light yellow

SMILES

OCC1OC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (1349.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	13.4989 mL	67.4946 mL	134.9892 mL
5 mM	2.6998 mL	13.4989 mL	26.9978 mL
10 mM	1.3499 mL	6.7495 mL	13.4989 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (67.49 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (67.49 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (67.49 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.95%

Select Batch:

Data Sheet (272 KB) SDS (799 KB)

COA (245 KB) HNMR (129 KB) GC (234 KB)

Handling Instructions (2659 KB)

References

[1]. Ikeda N, et al. Genotoxicity studies of glycidol fatty acid ester (glycidol linoleate) and glycidol. Food Chem Toxicol. 2012;50(11):3927-3933.

[2]. Stichler S, et al. Thiol-ene Clickable Poly(glycidol) Hydrogels for Biofabrication. Ann Biomed Eng. 2017;45(1):273-285.

[3]. Aasa J, et al. Internal Doses of Glycidol in Children and Estimation of Associated Cancer Risk. Toxics. 2019;7(1):7. Published 2019 Feb 1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	13.4989 mL	67.4946 mL	134.9892 mL	337.4730 mL
	5 mM	2.6998 mL	13.4989 mL	26.9978 mL	67.4946 mL
	10 mM	1.3499 mL	6.7495 mL	13.4989 mL	33.7473 mL
	15 mM	0.8999 mL	4.4996 mL	8.9993 mL	22.4982 mL
	20 mM	0.6749 mL	3.3747 mL	6.7495 mL	16.8736 mL
	25 mM	0.5400 mL	2.6998 mL	5.3996 mL	13.4989 mL
	30 mM	0.4500 mL	2.2498 mL	4.4996 mL	11.2491 mL
	40 mM	0.3375 mL	1.6874 mL	3.3747 mL	8.4368 mL
	50 mM	0.2700 mL	1.3499 mL	2.6998 mL	6.7495 mL
	60 mM	0.2250 mL	1.1249 mL	2.2498 mL	5.6245 mL
	80 mM	0.1687 mL	0.8437 mL	1.6874 mL	4.2184 mL
	100 mM	0.1350 mL	0.6749 mL	1.3499 mL	3.3747 mL

Oxiran-2-ylmethanol Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxiran-2-ylmethanol556-52-5GlycidolDrug Isomercancermutagenhemoglobin adductsmicronucleated immature erythrocytesSalmonella typhimuriumgenotoxic carcinogenEscherichia coliChinese hamster lung (CHL/IU) cellsIARC Group 2AclastogenInhibitorinhibitorinhibit

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