PD-1/PD-L1-IN-65
PD-1/PD-L1-IN-65 is a PD-1/PD-L1 checkpoint inhibitor, with an EC50 of 6.06 μM for blocking the PD-1/PD-L1 interaction and a Kd of 1.43 μM for PD-L1. PD-1/PD-L1-IN-65 upregulates pro-inflammatory cytokines IFN-γ, IL-1α, IL-1β and the cytolytic protein perforin, and reverses T cell exhaustion. PD-1/PD-L1-IN-65 enhances T cell-mediated cancer cell lysis. PD-1/PD-L1-IN-65 can be used in the research of breast cancer.
For research use only. We do not sell to patients.
- Formula: C30H23F3N4O2S
- Molecular Weight:560.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IL-1α |
IL-1β |
PD-1/PD-L1-IN-65 (Compound 17h) functionally blocks the interaction between PD-1 and PD-L1 in competitive ELISA assays, with an EC50 value of 6.06 μM[1].
PD-1/PD-L1-IN-65 (0-8 μM) effectively restores T cell signaling in cell-based PD-1/PD-L1 blockade assays, with an EC50 of 215 nM[1].
PD-1/PD-L1-IN-65 (10 μM) reverses PD-L1-mediated immunosuppression in the MDA-MB-231/activated PBMC co-culture system by upregulating IFN-γ, IL-1α, IL-1β, and perforin[1].
PD-1/PD-L1-IN-65 (5-10 μM) enhances T cell-mediated lysis of MDA-MB-231 cells without intrinsic cytotoxicity, confirming its selective immunomodulatory activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 560.59
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Formula C30H23F3N4O2S
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SMILES
CC1=C(SC(C2=CC=C(C(C#N)=C2)OCC(C)C)=N1)C(NC3=C(C(C4=CC=CC(C(F)(F)F)=C4)=CC=C3)C#N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PD-1/PD-L1-IN-65 Related Classifications
HY-184299 Related Classifications
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