Perfluorobutanesulfonic acid-13C3 sodium
Perfluorobutanesulfonic acid-13C3 sodium (PFBS-13C3 sodium) is the 13C-labeled Perfluorobutanesulfonic acid (HY-21191). Perfluorobutanesulfonic acid (PFBS) is a short-chain perfluoroalkyl substance and the main replacement for perfluorooctanesulfonic acid. Perfluorobutanesulfonic acid induces fat accumulation in human HepG2 hepatoma cells. Perfluorobutanesulfonic acid promotes lipid accumulation by activating PPARγ pathway and triggering oxidative stress, endoplasmic reticulum stress and calcium dyshomeostasis. Perfluorobutanesulfonic acid impairs reproduction and causes developmental disorders in offspring of Caenorhabditis elegans. Perfluorobutanesulfonic acid disrupts pancreatic organogenesis and lipid homeostasis in zebrafish embryos. Perfluorobutanesulfonic acid can be used in environmental toxicology, lipid metabolism and developmental toxicity studies.
For research use only. We do not sell to patients.
- CAS No.: 2708218-84-0
- Formula: C13C3F9NaO3S
- Molecular Weight:325.06
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PPARγ |
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2708218-84-0
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Unlabeled Cas 375-73-5
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Molecular Weight 325.06
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Formula C13C3F9NaO3S
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SMILES
F[13C](F)(F)[13C](F)(F)[13C](F)(F)C(F)(F)S(=O)(O[Na])=O
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Synonyms
PFBS-13C3 sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Sant KE, et al. Perfluorobutanesulfonic Acid Disrupts Pancreatic Organogenesis and Regulation of Lipid Metabolism in the Zebrafish, Danio rerio. Toxicol Sci. 2019;167(1):258-268. [Content Brief]
[2]. Yue Y, et al. Perfluorooctanesulfonic acid (PFOS) and perfluorobutanesulfonic acid (PFBS) impaired reproduction and altered offspring physiological functions in Caenorhabditis elegans. Food Chem Toxicol. 2020;145:111695. [Content Brief]
[3]. Ivantsova E, et al. Occurrence and toxicity mechanisms of perfluorobutanoic acid (PFBA) and perfluorobutane sulfonic acid (PFBS) in fish. Chemosphere. 2024;349:140815. [Content Brief]
[4]. Qi W, et al. Perfluorobutanesulfonic Acid (PFBS) Induces Fat Accumulation in HepG2 Human Hepatoma. Toxicol Environ Chem. 2020;102(10):585-606. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Perfluorobutanesulfonic acid-13C3 sodium Related Classifications
HY-21191S Related Classifications
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- Perfluorobutanesulfonic acid-13C3
- 2708218-84-0
- PFBS-13C3
- Isotope-Labeled Compounds
- Biochemical Assay Reagents
- PPAR
- Reactive Oxygen Species (ROS)
- Caenorhabditis elegans
- estrogen receptors
- Esr2a
- PPARγ
- nonalcoholic fatty liver disease
- peroxisome proliferator-activated receptor gamma
- Esr2b
- zebrafish embryos
- HepG2 human hepatoma cells
- Esr1
- Inhibitor
- inhibitor
- inhibit