375-73-5
375-73-5
Chemical Structure
Perfluorobutanesulfonic acid
Synonym(s): PFBS
- No. CAS: 375-73-5
- Formula:C4HF9O3S
- Molecular Weight:300.10
IUPAC Name: 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonic acid
InChIKey: JGTNAGYHADQMCM-UHFFFAOYSA-N
SMILES: O=S(C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)(O)=O
Biological Activity: Perfluorobutanesulfonic acid (PFBS) is a short-chain perfluoroalkyl substance and the main replacement for perfluorooctanesulfonic acid. Perfluorobutanesulfonic acid induces fat accumulation in human HepG2 hepatoma cells. Perfluorobutanesulfonic acid promotes lipid accumulation by activating PPARγ pathway and triggering oxidative stress, endoplasmic reticulum stress and calcium dyshomeostasis. Perfluorobutanesulfonic acid impairs reproduction and causes developmental disorders in offspring of Caenorhabditis elegans. Perfluorobutanesulfonic acid disrupts pancreatic organogenesis and lipid homeostasis in zebrafish embryos. Perfluorobutanesulfonic acid can be used in environmental toxicology, lipid metabolism and developmental toxicity studies[1][2][3][4].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
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Perfluorobutanesulfonic acid | 98.0% | Perfluorobutanesulfonic acid (PFBS) is a short-chain perfluoroalkyl substance and the main replacement for perfluorooctanesulfonic acid. Perfluorobutanesulfonic acid induces fat accumulation in human HepG2 hepatoma cells. Perfluorobutanesulfonic acid promotes lipid accumulation by activating PPARγ pathway and triggering oxidative stress, endoplasmic reticulum stress and calcium dyshomeostasis. Perfluorobutanesulfonic acid impairs reproduction and causes developmental disorders in offspring of Caenorhabditis elegans. Perfluorobutanesulfonic acid disrupts pancreatic organogenesis and lipid homeostasis in zebrafish embryos. Perfluorobutanesulfonic acid can be used in environmental toxicology, lipid metabolism and developmental toxicity studies. | ||||||||||||||||||||
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Perfluorobutanesulfonic acid-13C3 sodium | Perfluorobutanesulfonic acid-13C3 sodium (PFBS-13C3 sodium) is the 13C-labeled Perfluorobutanesulfonic acid (HY-21191). Perfluorobutanesulfonic acid (PFBS) is a short-chain perfluoroalkyl substance and the main replacement for perfluorooctanesulfonic acid. Perfluorobutanesulfonic acid induces fat accumulation in human HepG2 hepatoma cells. Perfluorobutanesulfonic acid promotes lipid accumulation by activating PPARγ pathway and triggering oxidative stress, endoplasmic reticulum stress and calcium dyshomeostasis. Perfluorobutanesulfonic acid impairs reproduction and causes developmental disorders in offspring of Caenorhabditis elegans. Perfluorobutanesulfonic acid disrupts pancreatic organogenesis and lipid homeostasis in zebrafish embryos. Perfluorobutanesulfonic acid can be used in environmental toxicology, lipid metabolism and developmental toxicity studies. | |||||||||||||||||||||
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Perfluorobutylsulfonyl fluoride | 99.83% | Perfluorobutylsulfonyl fluoride is a four-carbon polyfluorinated sulfonyl fluoride. Perfluorobutylsulfonyl fluoride serves as an intermediate that can be used for the synthesis of other compounds. | ||||||||||||||||||||
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Potassium perfluorohexanesulfonate | 98.0% | Potassium perfluorohexanesulfonate is an orally active surfactant found in sera of the general population. Potassium perfluorohexanesulfonate induces adaptive hepatocellular hypertrophy, decreases serum cholesterol and increases alkaline phosphatase in male mice. | ||||||||||||||||||||
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Perfluorohexanesulfonic acid-13C3 sodium | Perfluorohexanesulfonic acid-13C3 sodium is the 13C-labeled | |||||||||||||||||||||
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Perfluoroheptanesulfonic acid | 97.68% | Perfluoroheptanesulfonic acid (1-Perfluoroheptanesulfonic acid; Perfluoroheptanesulphonic acid; PFHpS) is a per- and polyfluoroalkyl substance (PFAS) that penetrates the skin and induces systemic toxicity and immunotoxicity. Perfluoroheptanesulfonic acid reduces the expression of PPARδ in liver tissue; it induces hepatocyte hypertrophy and necrosis in liver tissue and alters serum biochemical markers associated with liver injury. Perfluoroheptanesulfonic acid upregulates genes related to fatty acid metabolism, cell necrosis and inflammation, reduces the relative weights of the spleen and thymus, suppresses humoral immune responses, and alters the composition of immune cell subsets in the spleen and skin. The plasma concentration of Perfluoroheptanesulfonic acid correlates with food intake. Perfluoroheptanesulfonic acid and perfluorooctanesulfonic acid exhibit synchronous pulse events in influent samples from wastewater treatment plants. Perfluoroheptanesulfonic acid can be used in studies related to liver injury and immune system damage. | ||||||||||||||||||||
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1H,1H,2H,2H-Perfluorohexanesulfonic acid | 99.9% | 1H,1H,2H,2H-Perfluorohexanesulfonic acid (4:2 FTSA) is a short-chain perfluoroalkyl sulfonic acid with 6 carbon atoms that can bind to human serum albumin. | ||||||||||||||||||||
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Perfluorohexane sulfonamide | Perfluorohexane sulfonamide (FHxSA) is the inhibitor for carbonic anhydrase, that inhibits bovine CA and human CA II with IC50 of 0.122 and 1.38 μM. Perfluorohexane sulfonamide is a delayed-action insecticide, that can be used to control red fire ants (Solenopsis invicta). Perfluorohexane sulfonamide could be a environmental pollutant. | |||||||||||||||||||||
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Perfluoropentanesulfonic acid | 97.23% | Perfluoropentanesulfonic acid (PFPeS) is a per- and polyfluoroalkyl substance. Perfluoropentanesulfonic acid increases alkaline phosphatase (ALKP). Perfluoropentanesulfonic acid induces systemic toxicity in mouse models and alters the expression of genes related to fatty acid metabolism, inflammation and skin integrity in the liver and skin. | ||||||||||||||||||||
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Perfluorobutanesulfonamide | 98.56% | Perfluorobutanesulfonamide (FBSA) is a per- and polyfluoroalkyl substance (PFAS) and bovine carbonic anhydrase inhibitor with an IC50 of 1.486 µM. Perfluorobutanesulfonamide can be found as a contaminant in wastewater. Perfluorobutanesulfonamide inhibits the reversible CO2 hydration reaction catalyzed by zinc metalloenzymes. Perfluorobutanesulfonamide bioaccumulates in earthworms, is lethal to earthworms, and impairs avoidance of light. Perfluorobutanesulfonamide exhibits developmental toxicity in zebrafish embryos. Perfluorobutanesulfonamide can be used in research related to PFAS environmental chemistry and ecotoxicology. | ||||||||||||||||||||
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Sodium 1H,1H,2H,2H-perfluoro hexanesulfonate-13C2 | Sodium 1H,1H,2H,2H-perfluoro hexanesulfonate-13C2 is the 13C-labeled Sodium 1H,1H,2H,2H-perfluoro octanesulfonate. | |||||||||||||||||||||
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References
- [1]. Sant KE, et al. Perfluorobutanesulfonic Acid Disrupts Pancreatic Organogenesis and Regulation of Lipid Metabolism in the Zebrafish, Danio rerio. Toxicol Sci. 2019;167(1):258-268. [Content Brief]
- [2]. Yue Y, et al. Perfluorooctanesulfonic acid (PFOS) and perfluorobutanesulfonic acid (PFBS) impaired reproduction and altered offspring physiological functions in Caenorhabditis elegans. Food Chem Toxicol. 2020;145:111695. [Content Brief]
- [3]. Ivantsova E, et al. Occurrence and toxicity mechanisms of perfluorobutanoic acid (PFBA) and perfluorobutane sulfonic acid (PFBS) in fish. Chemosphere. 2024;349:140815. [Content Brief]
- [4]. Qi W, et al. Perfluorobutanesulfonic Acid (PFBS) Induces Fat Accumulation in HepG2 Human Hepatoma. Toxicol Environ Chem. 2020;102(10):585-606. [Content Brief]
