2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. PF-04827736

PF-04827736 (compound (S)-3) is a selective PDE1 inhibitor with IC50 values of 9.1 nM, 38 nM and 42 nM for PDE1B, PDE1C and PDE1A. PF-04827736 selectively inhibits human PDE1 over the other 10 superfamily members (PDE2-PDE11). PF-04827736 can be used for the study of cardiovascular disease.

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PF-04827736

PF-04827736 화학구조

CAS No. : 2230054-75-6

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This product is a controlled substance and not for sale in your territory.

Other Forms of PF-04827736:

PF-04827736 Related Antibodies

Top Publications Citing Use of Products

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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제품 설명

PF-04827736 (compound (S)-3) is a selective PDE1 inhibitor with IC50 values of 9.1 nM, 38 nM and 42 nM for PDE1B, PDE1C and PDE1A. PF-04827736 selectively inhibits human PDE1 over the other 10 superfamily members (PDE2-PDE11). PF-04827736 can be used for the study of cardiovascular disease[1].

IC50 & Target[1]

PDE1B

9.1 nM (IC50)

PDE1A

42 nM (IC50)

PDE1C

38 nM (IC50)

분자량

327.39

화학식

C17H21N5O2
CAS No.
SMILES

O(C)C=1C2=C(C(N[C@H](CC3=NNC(C)=C3)C)=NC=N2)C=CC1OC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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PF-04827736 Related Classifications

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  • 농도 희석 계산기

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-048277362230054-75-6PF04827736PF 04827736Phosphodiesterase (PDE)PDE1BPDE1C and PDE1Acardiovascular diseaseInhibitorinhibitorinhibit

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상품명:
PF-04827736
Cat. No.:
HY-120195A
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