2230054-75-6
2230054-75-6
Chemical Structure
PF-04827736
- CAS No.: 2230054-75-6
- Formula:C17H21N5O2
- Molecular Weight:327.39
IUPAC Name: (S)-7,8-dimethoxy-N-(1-(5-methyl-1H-pyrazol-3-yl)propan-2-yl)quinazolin-4-amine
InChIKey: JTROLECZHRVLFM-JTQLQIEISA-N
SMILES: O(C)C=1C2=C(C(N[C@H](CC3=NNC(C)=C3)C)=NC=N2)C=CC1OC
Biological Activity: PF-04827736 (compound (S)-3) is a selective PDE1 inhibitor with IC50 values of 9.1 nM, 38 nM and 42 nM for PDE1B, PDE1C and PDE1A. PF-04827736 selectively inhibits human PDE1 over the other 10 superfamily members (PDE2-PDE11). PF-04827736 can be used for the study of cardiovascular disease[1].
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PF-04827736 | PF-04827736 (compound (S)-3) is a selective PDE1 inhibitor with IC50 values of 9.1 nM, 38 nM and 42 nM for PDE1B, PDE1C and PDE1A. PF-04827736 selectively inhibits human PDE1 over the other 10 superfamily members (PDE2-PDE11). PF-04827736 can be used for the study of cardiovascular disease. | |||||||||||||||||||||
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References
Keywords
