PF-04827736
PF-04827736 (compound (S)-3) is a selective PDE1 inhibitor with IC50 values of 9.1 nM, 38 nM and 42 nM for PDE1B, PDE1C and PDE1A. PF-04827736 selectively inhibits human PDE1 over the other 10 superfamily members (PDE2-PDE11). PF-04827736 can be used for the study of cardiovascular disease.
For research use only. We do not sell to patients.
- CAS No.: 2230054-75-6
- Formula: C17H21N5O2
- Molecular Weight:327.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PDE1B 9.1 nM (IC50) |
PDE1A 42 nM (IC50) |
PDE1C 38 nM (IC50) |
Chemical Information
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CAS No. 2230054-75-6
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Molecular Weight 327.39
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Formula C17H21N5O2
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SMILES
O(C)C=1C2=C(C(N[C@H](CC3=NNC(C)=C3)C)=NC=N2)C=CC1OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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