PROTAC GPX4 degrader-2
PROTAC GPX4 degrader-2 (compound 18a) is a proteolysis targeting chimeras (PROTACs) that can degrade glutathione peroxidase 4 (GPX4), with the DC50, 48h value of 1.68 μM. PROTAC GPX4 degrader-2 induces the accumulation of lipid peroxides and mitochondrial depolarization, subsequently triggering ferroptosis. PROTAC GPX4 degrader-2 has anti-proliferative effect.
(Pink: GPX4 ligand (HY-175903); Blue: IAP ligand (HY-137159); Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 3035509-76-0
- Formula: C50H61ClN8O9
- Molecular Weight:953.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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GPX4 |
Chemical Information
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CAS No. 3035509-76-0
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Molecular Weight 953.52
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Formula C50H61ClN8O9
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SMILES
O=C(NCC1=CN(CCCCCCCC(N[C@@H]([C@H](O)C(N[C@@H](CC(C)C)C(OC)=O)=O)CC2=CC=CC=C2)=O)N=N1)C(C=C3)=CC=C3[C@H](N(C(CCl)=O)[C@@H](C(OC)=O)C4)C5=C4C6=CC=CC=C6N5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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