The human glioma pathogenesis-related protein is structurally related to plant pathogenesis-related proteins and its gene is expressed specifically in brain tumors

  • Gene. 1995 Jun 14;159(1):131-5. doi: 10.1016/0378-1119(95)00061-a.
E V Murphy  1 ,  Y Zhang ,  W Zhu ,  J Biggs
Affiliations
  • 1. Department of Neurologic Surgery, University of California, San Francisco 94143, USA.
PMID: 7607567 DOI: 10.1016/0378-1119(95)00061-a
Abstract

We report the cloning of a cDNA encoding GliPR (Glioma pathogenesis-related protein), a protein that is structurally similar to plant pathogenesis-related proteins. The GLIPR gene is highly expressed in the human brain tumor, Glioblastoma Multiforme/Astrocytoma, but neither in normal fetal or adult brain tissue, nor in other nervous system Tumors. GliPR shares up to 50% amino acid (aa) homology with plant pathogenesis-related proteins, group 1, over a region that comprises almost two thirds of the protein. We speculate that there may be functional similarities between the human and plant proteins as well.

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