1. GPCR/G Protein
    Neuronal Signaling
  2. Sigma Receptor
  3. (±)-Vesamicol hydrochloride

(±)-Vesamicol hydrochloride (Synonyms: (±)-AH5183 hydrochloride)

Cat. No.: HY-B1813A
Handling Instructions

(±)-Vesamicol hydrochloride ((±)-AH5183 hydrochloride) is a potent vesicular acetylcholine transport inhibitor with a Ki of 2 nM. (±)-Vesamicol hydrochloride also displays high affinity for σ1 and σ2 receptors with Kis of 26 nM and 34 nM, respectively.

For research use only. We do not sell to patients.

(±)-Vesamicol hydrochloride Chemical Structure

(±)-Vesamicol hydrochloride Chemical Structure

CAS No. : 120447-62-3

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Description

(±)-Vesamicol hydrochloride ((±)-AH5183 hydrochloride) is a potent vesicular acetylcholine transport inhibitor with a Ki of 2 nM. (±)-Vesamicol hydrochloride also displays high affinity for σ1 and σ2 receptors with Kis of 26 nM and 34 nM, respectively[1][2].

IC50 & Target

Ki: 2 nM (Vesicular acetylcholine transport), 26 nM (σ1 receptors) and 34 nM (σ2 receptors)[1]

In Vitro

The pharmacological actions of (±)-Vesamicol have been attributed to inhibition of acetylcholine transport into synaptic vesicles and the subsequent quantal release of acetylcholine[1].

In Vivo

(±)-Vesamicol (3 mg/kg; intraperitoneal injection; once; male Wistar rats) treatment increases the levels of cytosolic acetylcholine (ACh) in all regions of the brain, while those of vesicular ACh decreased in all regions except for the striatum[2].

Animal Model: Male Wistar rats (120-300 g)[2]
Dosage: 3 mg/kg
Administration: Intraperitoneal injection; once
Result: The levels of cytosolic acetylcholine (ACh) increased in all regions of the brain, while those of vesicular ACh decreased in all regions except for the striatum.
Molecular Weight

295.85

Formula

C₁₇H₂₆ClNO

CAS No.

120447-62-3

SMILES

O[[email protected]]1[[email protected]](N2CCC(C3=CC=CC=C3)CC2)CCCC1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(±)-Vesamicol(±)-AH5183Sigma ReceptorVesicularacetylcholinetransporternerveσ1-receptorσ2-receptorInhibitorinhibitorinhibit

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(±)-Vesamicol hydrochloride
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