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Cat. No.: HY-50858R

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Ruxolitinib phosphate (Standard)

Name: Ruxolitinib phosphate (Standard)
Brand: MedChemExpress
SKU: HY-50858R
Availability: PreOrder

(Synonyms: INCB018424 phosphate (Standard))

Ruxolitinib phosphate (Standard) is the analytical standard of Ruxolitinib phosphate (HY-50858). This product is intended for research and analytical applications. Ruxolitinib phosphate (INCB018424 phosphate) is a potent JAK1/2 inhibitor with IC₅₀s of 3.3 nM/2.8 nM, respectively, showing more than 130-fold selectivity over JAK3.

For research use only. We do not sell to patients.

CAS No.: 1092939-17-7
Formula: C₁₇H₂₁N₆O₄P
Molecular Weight:404.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Ruxolitinib phosphate (Standard) Chemical Structure

CAS No.: 1092939-17-7

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 1092939-17-7
Molecular Weight 404.36
Formula C₁₇H₂₁N₆O₄P
SMILES

N#CC[C@H](C1CCCC1)N2N=CC(C3=C4C=CNC4=NC=N3)=C2.O=P(O)(O)O
Synonyms

INCB018424 phosphate (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Quintas-Cardama A, et al. Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood, 2010, 115(15), 3109-3117. [Content Brief]

[2]. Fleischman AG, et al. The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition. Blood. 2013 Nov 21;122(22):3628-31. [Content Brief]

[3]. de Bock CE, et al. HOXA9 Cooperates with Activated JAK/STAT Signaling to Drive Leukemia Development. Cancer Discov. 2018 May;8(5):616-631. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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