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Cat. No.: HY-114072A

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(S,S)-J-113397

Name: (S,S)-J-113397
Brand: MedChemExpress
SKU: HY-114072A
Price: 470.00 USD
Availability: InStock
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(S,S)-J-113397 is an isomer of J-113397 (HY-114072). J-113397 is an Opioid Receptor antagonist.

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Pureté : 99.87%
CAS No.: 256640-46-7
Formule: C₂₄H₃₇N₃O₂
Masse moléculaire:399.57

Stockage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

(S,S)-J-113397 Chemical Structure

CAS No.: 256640-46-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

(S,S)-J-113397 is an isomer of J-113397 (HY-114072). J-113397 is an Opioid Receptor antagonist^[1].

Voir tous les produits spécifiques à Isoform Opioid Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	>10000 nM Compound: J-112444 (3S,4S)	Binding affinity in CHO cells stably expressing cloned human Opioid receptor delta 1 by displacing radioligand [3H][D-Ala2,D-Leu5]enkephalin Binding affinity in CHO cells stably expressing cloned human Opioid receptor delta 1 by displacing radioligand [3H][D-Ala2,D-Leu5]enkephalin	[PMID: 10602690]
CHO	IC₅₀	2600 nM Compound: J-112444 (3S,4S)	Binding affinity in CHO cells stably expressing cloned human Opioid receptor kappa 1 by displacing radioligand [3H]U-69593 Binding affinity in CHO cells stably expressing cloned human Opioid receptor kappa 1 by displacing radioligand [3H]U-69593	[PMID: 10602690]
CHO	IC₅₀	3300 nM Compound: J-112444 (3S,4S)	Binding affinity in CHO cells stably expressing cloned human Opioid receptor mu 1 by displacing diprenorphine Binding affinity in CHO cells stably expressing cloned human Opioid receptor mu 1 by displacing diprenorphine	[PMID: 10602690]
CHO	IC₅₀	820 nM Compound: J-112444 (3S,4S)	Binding affinity in CHO cells stably expressing cloned human Opioid receptor like 1 by displacing radioligand [125I]Tyr14-nociceptin Binding affinity in CHO cells stably expressing cloned human Opioid receptor like 1 by displacing radioligand [125I]Tyr14-nociceptin	[PMID: 10602690]
CHO	EC₅₀	>10000 nM Compound: J-112444 (3S,4S)	Agonistic activity against nociceptin produced GTPgammaS binding to Opioid receptor like 1 expressed in CHO cells Agonistic activity against nociceptin produced GTPgammaS binding to Opioid receptor like 1 expressed in CHO cells	[PMID: 10602690]
CHO	IC₅₀	>10000 nM Compound: J-112444 (3S,4S)	Antagonistic activity against nociceptin produced [35S]GTP-gamma-S, binding to Opioid receptor like 1 expressed in CHO cells Antagonistic activity against nociceptin produced [35S]GTP-gamma-S, binding to Opioid receptor like 1 expressed in CHO cells	[PMID: 10602690]

Chemical Information

CAS No. 256640-46-7
Appearance Solid
Masse moléculaire 399.57
Formule C₂₄H₃₇N₃O₂
Color White to off-white
SMILES

O=C1N([C@@H]2[C@H](CN(CC2)CC3CCCCCCC3)CO)C4=CC=CC=C4N1CC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Kawamoto H, et al. Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist: 1-[(3 R, 4 R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1, 3-dihydro-2 H-benzimidazol-2-one (J-113397)[J]. Journal of medicinal chemistry, 1999, 42(25): 5061-5063.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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