(S,S)-J-113397
Based on 1 Customer Validation
(S,S)-J-113397 is an isomer of J-113397 (HY-114072). J-113397 is an Opioid Receptor antagonist.
For research use only. We do not sell to patients.
- Purity : 99.87%
- CAS No.: 256640-46-7
- Formula: C24H37N3O2
- Molecular Weight:399.57
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Opioid Receptor Isoforms
More
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
>10000 nM
Compound: J-112444 (3S,4S)
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Binding affinity in CHO cells stably expressing cloned human Opioid receptor delta 1 by displacing radioligand [3H][D-Ala2,D-Leu5]enkephalin
Binding affinity in CHO cells stably expressing cloned human Opioid receptor delta 1 by displacing radioligand [3H][D-Ala2,D-Leu5]enkephalin
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[PMID: 10602690] |
| CHO | IC50 |
2600 nM
Compound: J-112444 (3S,4S)
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Binding affinity in CHO cells stably expressing cloned human Opioid receptor kappa 1 by displacing radioligand [3H]U-69593
Binding affinity in CHO cells stably expressing cloned human Opioid receptor kappa 1 by displacing radioligand [3H]U-69593
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[PMID: 10602690] |
| CHO | IC50 |
3300 nM
Compound: J-112444 (3S,4S)
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Binding affinity in CHO cells stably expressing cloned human Opioid receptor mu 1 by displacing diprenorphine
Binding affinity in CHO cells stably expressing cloned human Opioid receptor mu 1 by displacing diprenorphine
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[PMID: 10602690] |
| CHO | IC50 |
820 nM
Compound: J-112444 (3S,4S)
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Binding affinity in CHO cells stably expressing cloned human Opioid receptor like 1 by displacing radioligand [125I]Tyr14-nociceptin
Binding affinity in CHO cells stably expressing cloned human Opioid receptor like 1 by displacing radioligand [125I]Tyr14-nociceptin
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[PMID: 10602690] |
| CHO | EC50 |
>10000 nM
Compound: J-112444 (3S,4S)
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Agonistic activity against nociceptin produced GTPgammaS binding to Opioid receptor like 1 expressed in CHO cells
Agonistic activity against nociceptin produced GTPgammaS binding to Opioid receptor like 1 expressed in CHO cells
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[PMID: 10602690] |
| CHO | IC50 |
>10000 nM
Compound: J-112444 (3S,4S)
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Antagonistic activity against nociceptin produced [35S]GTP-gamma-S, binding to Opioid receptor like 1 expressed in CHO cells
Antagonistic activity against nociceptin produced [35S]GTP-gamma-S, binding to Opioid receptor like 1 expressed in CHO cells
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[PMID: 10602690] |
Chemical Information
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CAS No. 256640-46-7
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Appearance Solid
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Molecular Weight 399.57
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Formula C24H37N3O2
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Color White to off-white
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SMILES
O=C1N([C@@H]2[C@H](CN(CC2)CC3CCCCCCC3)CO)C4=CC=CC=C4N1CC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 10 mg/mL (25.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5027 mL | 12.5135 mL | 25.0269 mL | 62.5673 mL |
| 5 mM | 0.5005 mL | 2.5027 mL | 5.0054 mL | 12.5135 mL | |
| 10 mM | 0.2503 mL | 1.2513 mL | 2.5027 mL | 6.2567 mL | |
| 15 mM | 0.1668 mL | 0.8342 mL | 1.6685 mL | 4.1712 mL | |
| 20 mM | 0.1251 mL | 0.6257 mL | 1.2513 mL | 3.1284 mL | |
| 25 mM | 0.1001 mL | 0.5005 mL | 1.0011 mL | 2.5027 mL |
(S,S)-J-113397 Related Classifications
HY-114072A Related Classifications
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