(S,S)-J-113397
Based on 1 Customer Validation
(S,S)-J-113397 is an isomer of J-113397 (HY-114072). J-113397 is an Opioid Receptor antagonist.
For research use only. We do not sell to patients.
- Purity: 99.87%
- CAS No.: 256640-46-7
- Formula: C24H37N3O2
- Molecular Weight:399.57
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
All Opioid Receptor Isoforms
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Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
>10000 nM
Compound: J-112444 (3S,4S)
|
Binding affinity in CHO cells stably expressing cloned human Opioid receptor delta 1 by displacing radioligand [3H][D-Ala2,D-Leu5]enkephalin
Binding affinity in CHO cells stably expressing cloned human Opioid receptor delta 1 by displacing radioligand [3H][D-Ala2,D-Leu5]enkephalin
|
[PMID: 10602690] |
| CHO | IC50 |
2600 nM
Compound: J-112444 (3S,4S)
|
Binding affinity in CHO cells stably expressing cloned human Opioid receptor kappa 1 by displacing radioligand [3H]U-69593
Binding affinity in CHO cells stably expressing cloned human Opioid receptor kappa 1 by displacing radioligand [3H]U-69593
|
[PMID: 10602690] |
| CHO | IC50 |
3300 nM
Compound: J-112444 (3S,4S)
|
Binding affinity in CHO cells stably expressing cloned human Opioid receptor mu 1 by displacing diprenorphine
Binding affinity in CHO cells stably expressing cloned human Opioid receptor mu 1 by displacing diprenorphine
|
[PMID: 10602690] |
| CHO | IC50 |
820 nM
Compound: J-112444 (3S,4S)
|
Binding affinity in CHO cells stably expressing cloned human Opioid receptor like 1 by displacing radioligand [125I]Tyr14-nociceptin
Binding affinity in CHO cells stably expressing cloned human Opioid receptor like 1 by displacing radioligand [125I]Tyr14-nociceptin
|
[PMID: 10602690] |
| CHO | EC50 |
>10000 nM
Compound: J-112444 (3S,4S)
|
Agonistic activity against nociceptin produced GTPgammaS binding to Opioid receptor like 1 expressed in CHO cells
Agonistic activity against nociceptin produced GTPgammaS binding to Opioid receptor like 1 expressed in CHO cells
|
[PMID: 10602690] |
| CHO | IC50 |
>10000 nM
Compound: J-112444 (3S,4S)
|
Antagonistic activity against nociceptin produced [35S]GTP-gamma-S, binding to Opioid receptor like 1 expressed in CHO cells
Antagonistic activity against nociceptin produced [35S]GTP-gamma-S, binding to Opioid receptor like 1 expressed in CHO cells
|
[PMID: 10602690] |
Chemical Information
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CAS No. 256640-46-7
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Appearance Solid
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Molecular Weight 399.57
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Formula C24H37N3O2
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Color White to off-white
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SMILES
O=C1N([C@@H]2[C@H](CN(CC2)CC3CCCCCCC3)CO)C4=CC=CC=C4N1CC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)