S1PR1 Radioligand 1 

S1PR1 Radioligand 1(compound 6 h) is a specific S1PR1 radioligand with IC₅₀ = 8.7 nM. S1PR1 Radioligand 1 has good brain uptake and can be used as a S1PR1-specific F-18 radiotracer for studying the function of S1PR1 in brain diseases^[1].

The uptake of S1PR1 Radioligand 1 (compound 6 h) in the lung, liver and kidney of SD rats was relatively high. Among them, the lung uptake is the highest, which is 9.32±0.94 (%ID/g), followed by the liver, kidney, spleen, pancreas, heart and small intestine, which are 4.57±0.16, 3.57±0.17, 1.90±0.32, 1.68±0.14, 1.41± 0.10 and 1.06±0.19(%ID/g)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

471.42

C₂₂H₂₂F₅N₃O₃

2845249-11-6

CN(CC1=C(C=C(C=C1)C2=NOC(C3=CC(C(F)(F)F)=C(C=C3)OCCF)=N2)F)CCCO

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lin Qiu, et al. Discovery of a Promising Fluorine-18 Positron Emission Tomography Radiotracer for Imaging Sphingosine-1-Phosphate Receptor 1 in the Brain. J Med Chem. 2023 Mar 16.   [Content Brief]