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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
276 Results for "
Microsomal
" in MedChemExpress (MCE) Product Catalog:
Products (276)
276 Results for "Microsomal" in MCE Product Catalog:
Cat. No.: HY-W009713S
CAS No.: 344299-45-2
Research Areas:
3,4,5-Trimethoxyphenylacetic acid-d2 is the deuterated-labeled 3,4,5-Trimethoxyphenylacetic acid (HY-W009713). 3,4,5-Trimethoxyphenylacetic acid is a trimethoxylated phenylacetic acid derivative and also a major metabolite of 3,4,5-trimethoxyphenylethylamine. 3,4,5-Trimethoxyphenylacetic acid is produced from the oxidation of 3,4,5-trimethoxyphenylacetaldehyde catalyzed by mouse CYP2C29, and it also serves as a starting material for the synthesis of intermediates of methoxylated phenylacetamides. 3,4,5‑Trimethoxyphenylacetic acid exhibits no significant cataleptic activity and does not prolong pentobarbital-induced sleep duration. 3,4,5-Trimethoxyphenylacetic acid is used in metabolism-related studies .
Cat. No.: HY-W142456
CAS No.: 7535-59-3
Synonyms: N-Benzyl-L-pyroglutamic acid
Target:
Research Areas:
(S)-1-Benzyl-5-carboxy-2-pyrrolidinone (N-Benzyl-L-pyroglutamic acid) is an orally active H +/K +-ATPase inhibitor. (S)-1-Benzyl-5-carboxy-2-pyrrolidinone reduces free acidity and total acidity in gastric juice. (S)-1-Benzyl-5-carboxy-2-pyrrolidinone decreases ulcer formation in pylorus-ligated rats. (S)-1-Benzyl-5-carboxy-2-pyrrolidinone can be used for the research of peptic ulcers .
Category:
Human Gut Microbiota Metabolites other families Microorganisms Ketones, Aldehydes, Acids Marine natural products Metabolic Disease Plants Endogenous metabolite Disease Research Fields
Target:
Synonyms: 2-Hydroxyethanesulfonic acid sodium; Sodium isethionate
Target:
Synonyms: 2-Hydroxyethanesulfonic acid sodium (Standard); Sodium isethionate (Standard)
Category:
Cat. No.: HY-W089800
CAS No.: 18829-56-6
Synonyms: trans-2-Nonen-1-al
Target:
Research Areas:
trans-2-Nonenal (trans-2-Nonen-1-al) is an endogenous peroxidation product of polyunsaturated fatty acids, acting as an inhibitor of COX and 12-LOX, as well as an inducer of apoptosis. trans-2-Nonenal is also a malodorous compound secreted by the human body, and its content gradually increases with aging. trans-2-Nonenal inhibits the activities of multiple enzymes such as platelet membrane-bound PTPase, preferentially covalently modifies proteins at lysine residues to form immunogenic adducts, and regulates platelet Arachidonic acid (HY-109590) metabolism. trans-2-Nonenal also exhibits significant cytotoxicity, reduces the viability of keratinocytes, promotes their apoptosis, and effectively decreases the thickness of epidermal models and the number of proliferating cells. trans-2-Nonenal is commonly used in studies of thrombotic, atherosclerotic diseases, renal adenocarcinoma, etc. .
Cat. No.: HY-123599
CAS No.: 1884209-98-6
Target:
Research Areas:
IACS-4619 (compound 4) is a highly selective 2-aminopyrimidine-based MTH1 (MutT homolog 1) inhibitor (IC50=0.2 nM). IACS-4619 inhibits MTH1 by blocking its hydrolysis of oxidized purine nucleotides such as 8-oxo-dGTP, thereby preventing MTH1 from inhibiting the incorporation of oxidized nucleotides into DNA. IACS-4619 significantly inhibits endogenous MTH1 activity in MTH1-overexpressing U2OS cells, but without antiproliferative or cytotoxic effects on various human cancer and normal cell lines. IACS-4619 can be used in oncology research related to the MTH1 target .
Cat. No.: HY-183260
CAS No.: 3049354-73-3
Target:
Research Areas:
HBV-IN-57 is an orally active HBV inhibitor with pan-genotypic efficacy against HBV genotypes B/C. HBV-IN-57 inhibits HBV DNA replication and HBV capsid assembly. HBV-IN-57 can be used for the research of chronic hepatitis B .
Cat. No.: HY-183434
CAS No.: 21738-41-0
Desoxymansil is an anti-schistosomal agent. In mice, rabbits, dogs and monkeys, Desoxymansil undergoes oxidative metabolism via its isopropylaminomethyl side chain to produce a carboxylic acid metabolite, while this metabolic pathway is absent in rats. In rats, Desoxymansil undergoes α-carbon oxidation of the side chain to form an unstable aminomethanol that decomposes; the intermediate product is reduced to an alcohol metabolite, which is excreted in bile in the form of glucuronide. Desoxymansil can be used for the study of schistosomiasis .
Synonyms: Mifanertinib
Mefatinib free base (Mifanertinib) is an orally active EGFR and HER2 kinase inhibitor with IC50 values of 0.4 nM and 11.7 nM, respectively. Mefatinib free base inhibits tumor growth in mouse models of lung cancer xenografts that overexpress EGFR/HER2, carry EGFR mutations, or carry Erlotinib (HY-50896)-resistant EGFR double mutations. Mefatinib free base can be used for the research of advanced EGFR-mutant non-small cell lung cancer .
Synonyms: Mifanertinib dimaleate
Mefatinib (Mifanertinib dimaleate) is an orally active EGFR and HER2 kinase inhibitor with IC50 values of 0.4 nM and 11.7 nM, respectively. Mefatinib inhibits tumor growth in mouse models of lung cancer xenografts that overexpress EGFR/HER2, carry EGFR mutations, or carry Erlotinib (HY-50896)-resistant EGFR double mutations. Mefatinib can be used for the research of advanced EGFR-mutant non-small cell lung cancer .
Cat. No.: HY-152852S
Synonyms: Mifanertinib-d6
Cat. No.: HY-P81245
Synonyms: Cytochrome P450 1A2; cytochrome P450, family 1, subfamily a, polypeptide 2; Cytochrome P450 family 1 polypeptide 2; Cytochrome P450 subfamily I aromatic compound inducible polypeptide 2; Cyp1a2; CYPD45; P-450d; RATCYPD45; CP12; CP 12; P3-450; Aryl hydrocarbon hydroxylase; Dioxin inducable P3 45; Flavoprotein linked monooxygenase; Microsomal monooxygenase; P450 4; P450 form 4; P450 P3; P450(PA); Xenobiotic monooxygenase; P450 1A2.
Cat. No.: HY-P705910
Purity: ≥ 90%, as determined by reducing SDS-PAGE .
Synonyms: CYP3A5; Flavoprotein-Linked Monooxygenase; Cytochrome P450 Family 3 Subfamily A Member 5; Aryl Hydrocarbon Hydroxylase; P450PCN3; Alternative Protein CYP3A5; CP35; Microsomal Monooxygenase; PCN3; Xenobiotic Monooxygenase; Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 5; Unspecific Monooxygenase; Cytochrome P450, Family 3, Subfamily A, Polypeptide 5; Cytochrome P450 HLp2; Cytochrome P450-PCN3; Cytochrome P450 3A; Cytochrome P450 3A5; Cytochrome P-450; CYPIIIA5; DKFZp686I18188; Uncharacterized Protein DKFZp686I18188
Species:
Human
Source:
E. coli
Cat. No.: HY-184651
CAS No.: 3055155-53-5
Research Areas:
NLRP3-IN-93 is an orally active, blood-brain barrier-permeable NLRP3 inhibitor. NLRP3-IN-93 binds to the NACHT domain, blocks inflammasome assembly, and inhibits downstream IL-1β release, without significantly inhibiting various CYP isoforms. NLRP3-IN-93 demonstrates dose-dependent efficacy in mouse models of acute inflammation and Parkinson's disease, and exhibits good tolerability and an acceptable safety window in rats and dogs. NLRP3-IN-93 can be used in research on Parkinson's disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
