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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3338 Results for "
Domain
" in MedChemExpress (MCE) Product Catalog:
Products (3338)
3338 Results for "Domain" in MCE Product Catalog:
Cat. No.: HY-P77593
Pureté: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: KLRB1; CD161; Prev. NKR; Killer Cell Lectin-Like Receptor Subfamily B Member 1; NKR-P1A; C-Type Lectin Domain Family 5 Member B; CLEC5B; NKRP1A; Natural Killer Cell Surface Protein P1A; CD161 Antigen; HNKR-P1A; HNKR-P1a; NKR-P1; Killer Cell Lectin Like Re
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P78085
Pureté: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: KLRB1; CD161; Prev. NKR; Killer Cell Lectin-Like Receptor Subfamily B Member 1; NKR-P1A; C-Type Lectin Domain Family 5 Member B; CLEC5B; NKRP1A; Natural Killer Cell Surface Protein P1A; CD161 Antigen; HNKR-P1A; HNKR-P1a; NKR-P1; Killer Cell Lectin Like Re
Species:
Human
Source:
HEK293
Cat. No.: HY-P703561
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DCAF8; WD Repeat-Containing Protein 42A; Prev. WDR42A; FLJ35857; H326; GAN2; DDB1- And CUL4-Associated Factor 8; DDB1 And CUL4 Associated Factor 8; WD Repeat Domain 42A; DDB1; XPE-BF; Damage Specific DNA Binding Protein 1; XAP-1; DNA Damage-Binding Protei
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P810987
Synonyms: EDJ, ERJ3, HDJ9, PSEC0121, UNQ537/PRO1080, DNAJB11, DnaJ homolog subfamily B member 11, APOBEC1-binding protein 2, DnaJ protein homolog 9, ER-associated DNAJ, ER-associated Hsp40 co-chaperone, Endoplasmic reticulum DNA J Domain-containing protein 3, HEDJ, Human DnaJ protein 9, PWP1-interacting protein 4, ABBP-2, ER-resident protein ERdj3, ERdj3, ERj3p, hDj-9
Cat. No.: HY-P811876
Synonyms: NIRF, RNF107, UHRF2, E3 ubiquitin-protein ligase UHRF2, Np95/ICBP90-like RING finger protein, Nuclear protein 97, Nuclear zinc finger protein Np97, RING finger protein 107, RING-type E3 ubiquitin transferase UHRF2, Ubiquitin-like PHD and RING finger Domain-containing protein 2, Ubiquitin-like-containing PHD and RING finger Domains protein 2, Np95-like RING finger protein
Cat. No.: HY-P811876A
Synonyms: NIRF, RNF107, UHRF2, E3 ubiquitin-protein ligase UHRF2, Np95/ICBP90-like RING finger protein, Nuclear protein 97, Nuclear zinc finger protein Np97, RING finger protein 107, RING-type E3 ubiquitin transferase UHRF2, Ubiquitin-like PHD and RING finger Domain-containing protein 2, Ubiquitin-like-containing PHD and RING finger Domains protein 2, Np95-like RING finger protein
Cat. No.: HY-P703363
Pureté: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: DCAF10; WD Repeat-Containing Protein 32; Prev. WDR32; MGC10765; DDB1- And CUL4-Associated Factor 10; FLJ23201; DDB1 And CUL4 Associated Factor 10; WD Repeat Domain 32; DDB1; XPE-BF; Damage Specific DNA Binding Protein 1; XAP-1; DNA Damage-Binding Protein 1; XAP1; Xeroderma Pigmentosum Group E-Complementing Protein; Damage-Specific DNA Binding Protein 1 (127kD); Damage-Specific DNA-Binding Protein 1; Damage-Specific DNA Binding Protein 1, 127kDa; UV-Damaged DNA-Binding Protein 1; UV-DDB1; UV-Damaged DNA-Binding Factor; WHIKERS; DNA Damage-Binding Protein A; DDBA; HBV X-Associated Protein 1; XPCE; XPE-Binding Factor; XPCe; DDB P127 Subunit; DDBa; UV-DDB 1; XPE
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-LD004
14 million compounds
DEL technology enables the simultaneous screening of millions or billions of compounds in a single tube by covalently linking each small molecule with a unique DNA sequence. Traditional DEL screening primarily focuses on identifying non-covalent binding molecules, where interactions with the target are reversible. In contrast, DNA‑encoded covalent library is an ultra‑high‑throughput screening library developed on the basis of conventional DNA‑encoded library technology. It incorporates controllable electrophilic covalent warheads capable of forming irreversible covalent bonds with amino acid residues at the active sites of target proteins, including Cys, Lys, Ser, Tyr, and others. This covalent binding enhances binding affinity, prolongs residence time at the target site, and has the potential to overcome challenges associated with traditional non-covalent inhibitors, such as drug resistance or off-target effects.
Each compound in the library contains both a binding domain and an electrophilic warhead. It first recognizes and binds to the target through non covalent interactions, and then forms a stable covalent bond with key amino acid residues to achieve irreversible inhibition. This library is specifically designed for the discovery of potent, long lasting, and highly selective covalent inhibitors, particularly for undruggable targets such as kinases, GPCRs, proteases, and mutant oncoproteins. Each molecule is uniquely labeled with a DNA barcode for molecular identification and sequencing decoding.
This library is an advanced and highly diverse collection, consists of 35 independent sub-libraries with a total scaleof 14 million compounds, It incorporates over 14 experimentally validated covalent warheads capable of targeting cysteine, lysine, arginine, aspartic acid and glutamic acid. This library is constructed with diverse drug like core scaffolds and integrated controllable covalent warheads, it features structural diversity, reaction spec
Cat. No.: HY-P810989
Synonyms: EDJ; ERJ3; HDJ9; DnaJ homolog subfamily B member 11; APOBEC1-binding protein 2; ABBP-2; DnaJ protein homolog 9; ER-associated DNAJ; ER-associated Hsp40 co-chaperone; Endoplasmic reticulum DNA J Domain-containing protein 3; ER-resident protein ERdj3; ERdj3; ERj3p; HEDJ; Human DnaJ protein 9; hDj-9; PWP1-interacting protein 4
Cat. No.: HY-P73815
Pureté: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MFGE8; HP47; Prev. SPAG10; Breast Epithelial Antigen BA46; MFG-E8; Sperm Associated Antigen 10; SED1; Sperm Surface Protein HP47; Lactadherin; HMFG; HsT19888; MFGM; OAcGD3S; O-Acetyl Disialoganglioside Synthase; EDIL1; Milk Fat Globule-EGF Factor 8; BA46; Medin; Milk Fat Globule EGF And Factor V/VIII Domain Containing; Milk Fat Globule-EGF Factor 8 Protein
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P73816
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MFGE8; HP47; Prev. SPAG10; Breast Epithelial Antigen BA46; MFG-E8; Sperm Associated Antigen 10; SED1; Sperm Surface Protein HP47; Lactadherin; HMFG; HsT19888; MFGM; OAcGD3S; O-Acetyl Disialoganglioside Synthase; EDIL1; Milk Fat Globule-EGF Factor 8; BA46; Medin; Milk Fat Globule EGF And Factor V/VIII Domain Containing; Milk Fat Globule-EGF Factor 8 Protein
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P81048
Synonyms: Alpha 1 (VI) chain (61 AA) antibody; CO6A1_HUMAN antibody; COL6A1 antibody; Collagen alpha-1(VI) chain antibody; Collagen type VI alpha 1 antibody; Collagen VI alpha 1 polypeptide antibody; Collagen VI antibody; Human mRNA for collagen VI alpha 2 C terminal globular Domain antibody; OPLL antibody; PP3610 antibody
Cat. No.: HY-P85483
Synonyms: Ac2-121; AL022808; E3 ubiquitin-protein ligase UHRF1; FLJ21925; Hnp95 Huhrf1; HuNp95; ICBP90; Inverted CCAAT box binding protein of 90 kDa; Inverted CCAAT box binding protein, 90-Kd; Inverted CCAAT box-binding protein of 90 kDa; Liver regeneration-related protein LRRG126; MGC138707; NP95; Nuclear phosphoprotein, 95-KD; Nuclear protein 95; Nuclear zinc finger protein Np95; RING finger protein 106; RNF106; Transcription factor ICBP90; Ubiquitin like containing PHD and RING finger Domains protein 1; Ubiquitin like PHD and RING finger Domain containing protein 1; Ubiquitin-like PHD and RING finger Domain-containing protein 1; Ubiquitin-like protein containing PHD and RING finger Domains 1; Ubiquitin-like with PHD and ring finger Domains 1; Ubiquitin-like, containing PHD and RING finger Domains, 1; Ubiquitin-like-containing PHD and RING finger Domains protein 1; UHRF1; UHRF1_HUMAN.
Cat. No.: HY-P810459
Synonyms: SYNE3, Spectrin Repeat Containing Nuclear Envelope Family Member 3, Nesprin-3, LINC00341, NET53, Long Intergenic Non-Protein Coding RNA 341, Nuclear Envelope Spectrin Repeat Protein 3, KASH Domain-Containing Protein 3, NCRNA00341, C14orf139, FLJ25605, C14orf49, Nesp3, KASH3, Chromosome 14 Open Reading Frame 139, Chromosome 14 Open Reading Frame 49, Uncharacterized Protein C14orf113, Non-Protein Coding RNA 341, C14ORF139, NESPRIN-3, C14ORF49, NESP3
Cat. No.: HY-P706002
Pureté: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: ZC3H12A; Zinc Finger CCCH-Type Containing 12A; Regnase-1; MCPIP1; Monocyte Chemotactic Protein-Induced Protein 1; Zinc Finger CCCH Domain-Containing Protein 12A; Endoribonuclease ZC3H12A; MCP-Induced Protein 1; FLJ23231; MCPIP-1; MCPIP; Reg1; Bifunctional Endoribonuclease And Deubiquitinase ZC3H12A; MCP-1 Treatment-Induced Protein; MCP Induced Protein 1; Ribonuclease ZC3H12A; DJ423B22.1
Species:
Human
Source:
E. coli
Cat. No.: HY-P85577
Synonyms: Fas like protein; Apoptosis inducing protein TRICK2A/2B; Apoptosis inducing receptor TRAIL R2; CD 262; CD262; CD262 antigen; Cytotoxic TRAIL receptor 2; Death Domain containing receptor for TRAIL/Apo 2L; Death Domain containing receptor for TRAIL/Apo2L; Death receptor 5; DR 5; DR5; Fas like protein precursor; KILLER; KILLER/DR5; OTTHUMP00000123492; OTTHUMP00000123493; p53 regulated DNA damage inducible cell death receptor; killer; p53 regulated DNA damage inducible cell death receptor; killer; TNF related apoptosis inducing ligand receptor 2; TNF related apoptosis inducing ligand receptor 2; TNF-related apoptosis-inducing ligand receptor 2; TNFRSF10B; TR10B_HUMAN; TRAIL R2; TRAIL receptor 2; TRAIL-R2; TRAILR2; TRANCER; TRICK2; TRICK2A; TRICK2B; TRICKB; Tumor necrosis factor receptor like protein ZTNFR9; Tumor necrosis factor receptor like protein ZTNFR9; Tumor necrosis factor receptor superfamily member 10b; Tumor necrosis factor receptor superfamily, member 10b; ZTNFR9.
Cat. No.: HY-P87111
Synonyms: 1110014C03Rik antibody; 21 kDa transmembrane trafficking protein antibody; 21 kDa transmembrane-trafficking protein antibody; MGC102351 antibody; p23 antibody; p24 family protein delta 1 antibody; p24 family protein delta-1 antibody; p24(DELTA) antibody; p24delta antibody; p24delta1 antibody; 1110014C03Rik antibody; 21 kDa transmembrane trafficking protein antibody; 21 kDa transmembrane-trafficking protein antibody; MGC102351 antibody; p23 antibody; p24 family protein delta 1 antibody; p24 family protein delta-1 antibody; p24(DELTA) antibody; p24delta antibody; p24delta1 antibody; S31I125 antibody; S31III125 antibody; TMED 10 antibody; Tmed10 antibody; TMEDA_HUMAN antibody; Tmp 21 I antibody; Tmp 21 antibody; Tmp 21 I antibody; Tmp-21-I antibody; Transmembrane emp24 Domain containing protein 10 antibody; Transmembrane emp24 Domain-containing protein 10 antibody; Transmembrane emp24-like trafficking protein 10 (yeast) antibody; Transmembrane protein Tmp21 antibody; Transmembrane trafficking protein 21kD antibody;
Cat. No.: HY-P705359
Pureté: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HLA-A; MHC Class 1 Antigen; Major Histocompatibility Complex, Class I, A; MHC ClassI Antigen; HLA Class I Histocompatibility Antigen, A Alpha Chain; Lymphocyte Antigen; MHC Class I Antigen HLA-A Heavy Chain; HLA-A*6602 Antigen; Leukocyte Antigen Class I-A; HLA-Aw34.2 Antigen; HLAA; HLA-A-6802 Protein; Major Histocompatibility Complex Class I HLA-A-32 Protein; HLA-A-0203 Protein; HLA Class I Histocompatibility Antigen, A-1 Alpha Chain; MHC Class1 Antigen; HLA Class I Histocompatibility Antigen A Alpha Chain; Leukocyte Antigen; Signal Peptide Alpha1 And Alpha2 Domain; HLA-A26.4 Antigen; HLA Class I Histocompatibility Antigen; HLA-A10SA Antigen; MHC HLA-A Cell Surface Glycoprotein; MHC Class I HLA-A; HLA Class I A Locus Antigen A*68new; HLA-A26.3 Antigen; MHC Class I Human Leukocyte Antigen; HLA-A30.2 Antigen; Ig-Like Domain-Containing Protein; HLA-A2new Protein; MHC Class I Antigen Null Protein; Leucocyte Antigen; HLA-A Alpha1 And Alpha2 Domains; HLA-A9HH Antigen; MHC Class I Antigen Heavy Chain; MHC Class I Anti; Leucocyte Antigen A Alpha Chain; HLA-A29 Variant; Truncated MHC Class I Antigen; HLA-A25 Protein; Truncated MHC Class I Protein; MHC Alpha Chain; MHC Class I Antigen Precusor; HLA-A*02:01NEW; MHC Class I Protein (HLA-A); HLA-A Protein; HLA-A Locus Alpha 2 Domain; HLA Class I A; Lymphocyte Antigen M7-A2.2; Alpha1 Domain; MHC Class I Antigen R69772; MHC Class I; Human Leukocyte Antigen A; HLA-A*24var; HLA-A*24:02:01:01 Variant; HLA-A*0210; MHC Class I Antigen HLA-A; HLA-A*2903; Cell Surface Glycoprotein; HLA-A-6802; Leucocyte Antigen Class I; HLA-A-0203; Leukocyte Antigen Class I; HLA-A*3303; Transplantation Antigen; HLA-A*0218; HLA Class I Heavy Chain; HLA-A2 SLU; HLA-A11 Antigen A11.2; HLA-A-02; MHC Class I Antigen A; HLA-A-32; MHC Leukocyte Antigen; HLA-A30; MHC Class II Antigen; HLA-A25; MHC Class I Antigene; HLA-A26; Cell Surface Antigen; HLA-A*; HLA-A Alpha 1 Domain; HLA-A2; MHC Class I Antigen; A1102; MHC Class I Protein; Hla-A; HLA Class I Antigen; HLA-H; Leucocyte Antigen A; HLA_A; MCH Class I Antigen; HLA; B2M; Beta 2-Microglobulin; Beta-2-Microglobulin; Beta-2-Microglobin; Beta Chain Of MHC Class I Molecules; AMYLD6; Beta 2-Microglobulin Protein; MHC1D4; Human Nkt Tcr Alpha Chain; IMD43; Human Nkt Tcr Beta Chain
Species:
Human
Source:
HEK293
Cat. No.: HY-180419
CAS No.: 1883721-73-0
Domaines de recherche:
SF-3-030 is a potent, selective and non-ATP competitive ERK1/2 inhibitor. SF-3-030 selectively induces apoptosis in melanoma cells containing mutated BRaf and constitutively active ERK1/2 signalling. SF-3-030 mitigates multiple features of asthma in a murine model of asthma. SF-3-030 can be used for the research of asthma and melanomasup .
Cat. No.: HY-L045
4,317 compounds
Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulation of cancer progression.
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. A variety of HF-1 target genes have been identified thus far which encode proteins that play key roles in critical developmental and physiological processes including angiogenesis/vascular remodeling, erythropoiesis, glucose transport, glycolysis, iron transport, and cell proliferation/survival.
HIF-1 is a heterodimeric transcription factor consisting of a constitutively expressed β-subunit and an oxygen-regulated α-subunit. The unique feature of HIF-1 is the regulation of HIF-1α expression and activity based upon the cellular O2 concentration. Under normoxic conditions, hydroxylation of HIF-1α on these different proline residues is essential for HIF proteolytic degradation by promoting interaction with the von Hippel-Lindau tumor-suppressor protein (pVHL) through hydrogen bonding to the hydroxyproline-binding pocket in the pVHL β-domain. As oxygen levels decrease, hydroxylation of HIF decreases; HIF-1α then no longer binds pVHL, and becomes stabilized, allowing more of the protein to translocate to the cell’s nucleus, where it acts as a transcription factor, upregulating (often within minutes) the production of proteins that stimulate blood perfusion in tissues and thus tissue oxygenation.
MCE offers a unique collection of 4,317 oxygen sensing related compounds targeting HIF/HIF Prolyl-Hydroxylase, MAPK/ERK, PI3K/AKT signaling pathways, etc. MCE Oxygen Sensing Compound Library is a useful tool to study hypoxia, oxidative stress and discover new anti-cancer drugs.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
