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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
32 Results for "
Fragile
" in MedChemExpress (MCE) Product Catalog:
Products (32)
32 Results for "Fragile" in MCE Product Catalog:
Cat. No.: HY-N16480
CAS No.: 651750-97-9
Synonyms: Lindetannin trimer
Target:
Cat. No.: HY-181828
CAS No.: 3118902-53-4
Target:
Research Areas:
SePP is a blood-brain barrier-permeable NMDAR antagonist and dopamine/norepinephrine reuptake inhibitor, with a Ki of 28.7 nM for rat NMDAR. SePP exerts anticonvulsant effects. SePP can be used in research related to fragile X syndrome .
Cat. No.: HY-P75187
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FHIT; AP3A Hydrolase; Fragile Histidine Triad Diadenosine Triphosphatase; FRA3B; Bis(5'-Adenosyl)-Triphosphatase; Fragile Histidine Triad Protein; AP3Aase; Fragile Histidine Triad; Diadenosine 5',5'''-P1,P3-Triphosphate Hydrolase; Truncated Diadenosine Tr
Species:
Human
Source:
E. coli
Cat. No.: HY-182587
CAS No.: 1359087-83-4
Target:
Research Areas:
VU0415248 is a selective muscarinic acetylcholine receptor 1 (M1) inhibitor. VU0415248 inhibits acetylcholine-induced calcium mobilization in cells expressing human and rat M1 muscarinic acetylcholine receptors, with an IC50 of 0.4 and 0.18 μM, respectively. VU0415248 is applicable to the research of Parkinson's disease, movement disorders and fragile X syndrome .
Cat. No.: HY-114515
CAS No.: 1034442-21-1
Synonyms: RG7090 sulfate; RO4917523 sulfate
Target:
Research Areas:
Basimglurant (RG7090; RO4917523) sulfate is a selective, orally active, blood-brain barrier permeable negative allosteric modulator of metabotropic glutamate receptor 5 (mGluR5), with a Ki of 1.4 nM (against [ 3H]-ABP688 (HY-110141)) and 35.6 nM (against [ 3H]-MPEP (HY-14609A)). Basimglurant sulfate inhibits mGlu5-mediated signaling pathways and receptor constitutive activity, regulates dopamine levels in the nucleus accumbens, exerts anxiolytic, antidepressant-like, analgesic and arousal-promoting effects, and alters δ-wave power during non-rapid eye movement sleep. Basimglurant sulfate can be used in research on depression, fragile X syndrome, anxiety disorders, etc .
Cat. No.: HY-DY1111
CAS No.: 1539318-40-5
Target:
Research Areas:
DFHBI-2T solution is a membrane-permeable, RNA aptamer-activated fluorescent probe (Ex/Em=500 nm/523 nm), with a Kd value of 1300 nM for the RNA aptamer Spinach2. DFHBI-2T solution binds to Spinach2, converting the fluorophore to a fluorescent state, stabilizing its planar structure to facilitate the radiative fluorescence decay pathway, and forming a complex with red-shifted excitation and emission peaks. DFHBI-2T solution can be used for RNA imaging in live cells. It is also applicable to research related to fragile X-associated tremor/ataxia syndrome .
Solvent and concentration: DMSO: 5 mM
Solvent and concentration: DMSO: 5 mM
Cat. No.: HY-P705480
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FXR1; MYOPMIL; FMR1 Autosomal Homolog 1; MYORIBF; RNA-Binding Protein FXR1; CMYO9A; CDNA FLJ58644, Highly Similar To Fragile X Mental Retardation Syndrome-Related Protein 1; CMYO9B; Fragile X Mental Retardation Autosomal Homolog Variant P1K; CMYP9A; Fragi
Species:
Human
Source:
E. coli
Cat. No.: HY-W747508
CAS No.: 58814-86-1
Target:
Research Areas:
Aculeacin A is a β-1,3-glucan synthase inhibitor. Aculeacin A is an antifungal antibiotic. Aculeacin A inhibits cell wall glucan synthesis in growing yeast cells, induces cell lysis, osmotic fragility, cell aggregation and abnormal cell morphology, without affecting the synthesis of proteins, nucleic acids or mannan. Aculeacin A acts only on growing yeast cells and has a narrow antifungal spectrum, mainly targeting Candida and Torulopsis species. Aculeacin A shows reduced activity in human serum and exhibits a paradoxical dose-response pattern. Aculeacin A has an inoculum effect against some Candida albicans strains, and its activity is pH-stable. Aculeacin A can be used in studies of fungal infections, such as those caused by Candida, Torulopsis and other species .
Cat. No.: HY-15446R
CAS No.: 802906-73-6
Synonyms: RG7090 (Standard); RO4917523 (Standard)
Target:
Research Areas:
Basimglurant (RG7090; RO4917523) (Standard) is the analytical standard of Basimglurant. This product is intended for research and analytical applications. Basimglurant is a selective, orally active, blood-brain barrier permeable negative allosteric modulator of metabotropic glutamate receptor 5 (mGluR5), with a Ki of 1.4 nM (against [ 3H]-ABP688 (HY-110141)) and 35.6 nM (against [ 3H]-MPEP (HY-14609A)). Basimglurant inhibits mGlu5-mediated signaling pathways and receptor constitutive activity, regulates dopamine levels in the nucleus accumbens, exerts anxiolytic, antidepressant-like, analgesic and arousal-promoting effects, and alters δ-wave power during non-rapid eye movement sleep. Basimglurant can be used in research on depression, fragile X syndrome, anxiety disorders, etc.
Cat. No.: HY-P702888
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CBL; RING-Type E3 Ubiquitin Transferase CBL; Prev. CBL2; RING Finger Protein 55; RNF55; Proto-Oncogene C-Cbl; E3 Ubiquitin-Protein Ligase CBL; Oncogene CBL2; C-Cbl; Fragile Site, Folic Acid Type, Rare, Fra(11)(Q23.3); Cas-Br-M (Murine) Ecotropic Retrovira
Species:
Human
Source:
E. coli
Cat. No.: HY-125444
CAS No.: 1622059-04-4
Target:
Research Areas:
TH251 is a LIMK1 and LIMK2 inhibitor with IC50s of 52 nM and 47 nM against LIMK1 and LIMK2, respectively. TH251 binds to inactive αC-out and DFG-out LIMK1 conformations, inhibits unphosphorylated LIMK1 and LIMK2 enzymatic activity, and exhibits unchanged potency despite PAK-mediated phosphorylation of either kinase. TH251 can be used for the research of cancers, glaucoma, and CNS diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
