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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
30 Results for "
PRMT3
" in MedChemExpress (MCE) Product Catalog:
Products (30)
30 Results for "PRMT3" in MCE Product Catalog:
Cat. No.: HY-128717C
CAS No.: 2227587-25-7
Synonyms: EPZ019997 hydrochloride
Target:
Research Areas:
GSK3368715 (EPZ019997) hydrochloride is an orally active, reversible, SAM-noncompetitive type I protein arginine methyltransferase (PRMT) inhibitor with IC50 values of 3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), and 1.7 nM (PRMT8). GSK3368715 hydrochloride induces a shift in arginine methylation states, alters exon usage, and exhibits potent anticancer activity .
Cat. No.: HY-128717B
CAS No.: 2227587-26-8
Synonyms: EPZ019997 trihydrochloride
Target:
Research Areas:
GSK3368715 trihydrochloride (EPZ019997) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 trihydrochloride (EPZ019997) produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity .
Cat. No.: HY-P76551
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRMT3; Protein Arginine N-Methyltransferase 3; Prev. HRMT1L3; HMT1 HnRNP Methyltransferase-Like 3; Heterogeneous Nuclear Ribonucleoprotein Methyltransferase-Like Protein 3; Protein Arginine Methyltransferase 3; HMT1 HnRNP Methyltransferase-Like 3 (S. Cere
Species:
Human
Source:
E. coli
Cat. No.: HY-159733
Research Areas:
E3 Ligase Ligand-linker Conjugate 120 is a conjugate of the E3 ubiquitin ligase ligand and linker of PROTAC PRMT3 degrader 1 (HY-159728) .
Cat. No.: HY-183061
Target:
Research Areas:
MrTAC-8, methylarginine-targeting chimera (MrTAC), is a BRD4 degrader with DC50 values of 46 nM in HeLa cells. MrTAC-8 recruits PRMT1, PRMT3, PRMT4, PRMT5, and PRMT7 to target proteins, inducing arginine methylation that triggers lysosomal degradation. MrTAC-8 degrades proteins across diverse subcellular localizations and independent of native proteolytic routes. MrTAC-8 can be used for the research of cervical cancer, glioblastoma .
Cat. No.: HY-10929R
CAS No.: 1197196-48-7
Research Areas:
UNC0224 (Standard) is the analytical standard of UNC0224 (HY-10929). This product is intended for research and analytical applications. UNC0224 is a potent and selective histone methyltransferase G9a inhibitor with a Ki of 2.6 nM, an IC50 of 15 nM and a Kd of 23 nM. UNC0224 also potently inhibits b>GLP with assay-dependent IC50 values of 20-58 nM. UNC0224 is inactive against SET7/9, SET8/PreSET7, PRMT3 and JMJD2E .
Cat. No.: HY-183653
CAS No.: 3062376-05-7
Target:
Research Areas:
AK442 is a selective PRMT4 (CARM1) inhibitor with an IC50 of 2.6 nM against human targets. AK442 is applicable to breast cancer-related research .
Cat. No.: HY-186163
CAS No.: 636564-27-7
Target:
Research Areas:
CC-410 is a selective Nicotinamide N-methyltransferase (NNMT) inhibitor with a human IC50 value of 1.6 µM. CC-410 impairs terminal adipocyte differentiation via glucocorticoid signaling network deregulation, inhibits adipogenesis and lipid accumulation with time-sensitive activity limited to early adipogenesis stages. CC-410 can be used for the researches of early-onset obesity, glucocorticoid-induced obesity .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
