2227587-25-7
Chemical Structure
GSK3368715 hydrochloride
Synonym(s): EPZ019997 hydrochloride
- CAS No.: 2227587-25-7
- Formula:C20H39ClN4O2
- Molecular Weight:403.00
IUPAC Name: N1-((3-(4,4-bis(ethoxymethyl)cyclohexyl)-1H-pyrazol-4-yl)methyl)-N1,N2-dimethylethane-1,2-diamine hydrochloride
InChIKey: WRVJUOWIQSTJPE-UHFFFAOYSA-N
SMILES: CNCCN(CC1=CNN=C1C2CCC(COCC)(COCC)CC2)C.Cl
Biological Activity: GSK3368715 (EPZ019997) hydrochloride is an orally active, reversible, SAM-noncompetitive type I protein arginine methyltransferase (PRMT) inhibitor with IC50 values of 3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), and 1.7 nM (PRMT8). GSK3368715 hydrochloride induces a shift in arginine methylation states, alters exon usage, and exhibits potent anticancer activity[1].
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GSK3368715 hydrochloride | GSK3368715 (EPZ019997) hydrochloride is an orally active, reversible, SAM-noncompetitive type I protein arginine methyltransferase (PRMT) inhibitor with IC50 values of 3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), and 1.7 nM (PRMT8). GSK3368715 hydrochloride induces a shift in arginine methylation states, alters exon usage, and exhibits potent anticancer activity. | |||||||||||||||||||||
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