44 Results for "

TIMP

" in MedChemExpress (MCE) Product Catalog:
Products (44)

44 Results for "TIMP" in MCE Product Catalog:

Cat. No.: HY-RS23282
Research Areas:  

Others

Timp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Timp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS16840
Research Areas:  

Others

Timp1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Timp1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-162902
CAS No.: 3001361-04-9
Target:  

TGF-β Receptor

Research Areas:  

Cardiovascular Disease

ALK5-IN-82 is a potent and selective inhibitor against activin receptor-like kinase 5 (ALK5) with an IC50 value of 9.1 nM. ALK5-IN-82 inhibits the protein expression of α-smooth muscle actin (α-SMA), collagen I and tissue inhibitor of metalloproteinase 1 (TIMP-1)/matrix metalloproteinase 13 (MMP-13) in transforming growth factor-β-induced human umbilical vein endothelial cells. ALK5-IN-82 is promising for research of cardiac fibrosis .
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Cat. No.: HY-172258
Target:  

5-HT Receptor

Research Areas:  

Cancer

5-HT2B antagonist-2 (Compound 19c) is a 5HT2B receptor antagonist with an IC50 of 1.09 nM. 5-HT2B antagonist-2 can downregulate the expression of fibrosis-related genes α-SMA, Timp1, Col1a1, and Col3a1, and significantly reduce the deposition of fibrosis, thereby reducing the fibrotic area and inhibiting the fibrotic process in CCl4-induced liver fibrosis mouse models. 5-HT2B antagonist-2 can be used in the study of immune inflammatory-related diseases, particularly in the research of pulmonary fibrosis diseases .
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Cat. No.: HY-P992307

Target:  

MMP

Research Areas:  

Inflammation/Immunology

Anti-TIMP-1 Antibody is a monoclonal antibody that targets TIMP1. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-TIMP-1 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
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Cat. No.: HY-P4890A
Relaxin H3 (human) TFA is a relaxin peptide with anti-inflammatory, anti-apoptotic, anti-pyroptotic, anti-migratory, protective and anti-fibrotic activities. Relaxin H3 (human) TFA acts on RXFP1 to generate cAMP and reduce the levels of ATP and ROS. Relaxin H3 (human) TFA inhibits renal inflammatory pyroptosis (pyroptosis), NLRP3 inflammasome activation, caspase-1 activation, IL-1β/IL-18 secretion, collagen synthesis, TGF-β1 signaling pathway, Smad2 phosphorylation, myofibroblast differentiation, TIMP expression, and HRMEC migration. Relaxin H3 (human) TFA activates AMPK, upregulates MFN2 expression, improves mitochondrial quality control and membrane potential, inhibits apoptosis (apoptosis) and pyroptosis, restores retinal ultrastructure, and reverses excessive left ventricular collagen expression. Relaxin H3 (human) TFA can be used in studies related to kidney stones, nephrocalcinosis, diabetic cardiomyopathy, fibrotic cardiomyopathy, and diabetic retinopathy .
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Cat. No.: HY-RS17383
Research Areas:  

Others

Timp2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Timp2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS24780
Research Areas:  

Others

Timp3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Timp3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P73596
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TIMP1; Collagenase Inhibitor; Prev. CLGI; EPA; Prev. TIMP; Tissue Inhibitor Of Metalloproteinase 1 (Erythroid Potentiating Activity, Collagenase Inhibitor); Tissue Inhibitor Of Metalloproteinases 1; Epididymis Secretory Sperm Binding Protein; Metalloprote
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P704924
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TIMP1; Collagenase Inhibitor; Prev. CLGI; EPA; Prev. TIMP; Tissue Inhibitor Of Metalloproteinase 1 (Erythroid Potentiating Activity, Collagenase Inhibitor); Tissue Inhibitor Of Metalloproteinases 1; Epididymis Secretory Sperm Binding Protein; Metalloprote
Species:  
Mouse
Source:  
HEK293
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Cat. No.: HY-P73441
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TIMP1; Collagenase Inhibitor; Prev. CLGI; EPA; Prev. TIMP; Tissue Inhibitor Of Metalloproteinase 1 (Erythroid Potentiating Activity, Collagenase Inhibitor); Tissue Inhibitor Of Metalloproteinases 1; Epididymis Secretory Sperm Binding Protein; Metalloprote
Species:  
Rat
Source:  
HEK293
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Cat. No.: HY-P73597
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TIMP1; Collagenase Inhibitor; Prev. CLGI; EPA; Prev. TIMP; Tissue Inhibitor Of Metalloproteinase 1 (Erythroid Potentiating Activity, Collagenase Inhibitor); Tissue Inhibitor Of Metalloproteinases 1; Epididymis Secretory Sperm Binding Protein; Metalloprote
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P71055
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TIMP1; Collagenase Inhibitor; Prev. CLGI; EPA; Prev. TIMP; Tissue Inhibitor Of Metalloproteinase 1 (Erythroid Potentiating Activity, Collagenase Inhibitor); Tissue Inhibitor Of Metalloproteinases 1; Epididymis Secretory Sperm Binding Protein; Metalloprote
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P83517
Synonyms: CSC21K; TIMP 2; TIMP2

Host:  

Rabbit

Application:  

WB, FC

Reactivity:  

Human

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Cat. No.: HY-P811588
Synonyms: Metalloproteinase inhibitor 4, Tissue inhibitor of metalloproteinases 4, TIMP-4, TIMP4

Host:  

Rabbit

Application:  

WB

Reactivity:  

Human, Mouse

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Cat. No.: HY-P71368
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TIMP4; Tissue Inhibitor Of Metalloproteinase 4; TIMP Metallopeptidase Inhibitor 4; Metalloproteinase Inhibitor 4; Tissue Inhibitor Of Metalloproteinases 4; TIMP-4
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P86016

Host:  

Mouse

Application:  

IHC-P, ICC/IF, ELISA

Reactivity:  

Human

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Cat. No.: HY-P86018

Host:  

Mouse

Application:  

IHC-P, ICC/IF, ELISA

Reactivity:  

Human

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Cat. No.: HY-P73442
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TIMP2; Tissue Inhibitor Of Metalloproteinase 2; TIMP Metallopeptidase Inhibitor 2; Testicular Secretory Protein Li 57; CSC-21K; TIMP-2; Tissue Inhibitor Of Metalloproteinases 2; DDC8; Metalloproteinase Inhibitor 2
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-N19029
CAS No.: 21871-10-3
Vernodalin is an orally active, cytotoxic sesquiterpene lactone with a Kd value of 9.55 μM for p38 MAPK. Vernodalin downregulates the expression of phosphorylated ERK, JNK, AKT, PI3K, mTOR, p38MAPK, FAK, MMP-2, MMP-9, and uPA, while upregulates the expression of TIMP-1 and TIMP-2. Vernodalin increases ROS production, upregulates the expression of Bax and caspase 3, downregulates the expression of Bcl-2, and induces apoptosis (apoptosis), oxidative stress response and cell cycle arrest. Vernodalin inhibits the proliferation, adhesion and metastasis of cancer cells. Vernodalin enhances the activity of VEGF-B, AMPK and eNOS signaling pathways. Vernodalin alleviates myocardial injury and restores hemodynamic parameters. Vernodalin inhibits the growth of Trypanosoma brucei rhodesiense. Vernodalin can be used in research related to various cancers including gastric cancer, colorectal cancer and lung cancer, as well as African human trypanosomiasis and myocardial infarction .
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