Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
brain synaptosomes
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "brain synaptosomes" in MCE Product Catalog:
Cat. No.: HY-B1110S
CAS No.: 1795140-41-8
Synonyms: (±)-Nomifensine-d3 maleate; Nomifensin-d3 maleate
Cat. No.: HY-18610R
CAS No.: 34041-84-4
Synonyms: Ro 8-4650 hydrochloride (Standard)
Research Areas:
Diclofensine (Ro 8-4650) hydrochloride (Standard) is the analytical standard of Diclofensine hydrochloride. This product is intended for research and analytical applications. Diclofensine hydrochloride is an orally active neuronal monoamine uptake inhibitor. Diclofensine hydrochloride blocks the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3 and 3.7 nM, respectively. Diclofensine hydrochloride potentiates norepinephrine-induced hypertension and attenuates Tyramine (HY-W007606)-induced hypertension. Diclofensine hydrochloride produces psychostimulant and mood-elevating effects without causing sudden disappearance or withdrawal reactions. Diclofensine hydrochloride can be used in the research of moderate to severe depression.
Cat. No.: HY-18610S
CAS No.: 1794780-41-8
Cat. No.: HY-184316
CAS No.: 98644-22-5
Target:
Research Areas:
CM 57373 is an orally active anorectic agent. CM 57373 releases serotonin and inhibits serotonin reuptake in rat brain synaptosomes. CM 57373 reduces food intake, decreases body weight and alleviates experimentally induced hyperphagia. CM 57373 can be used in obesity research .
Cat. No.: HY-184802
CAS No.: 80273-79-6
Target:
Research Areas:
Tefludazine is an orally active antagonist of dopamine D2 receptor with an IC50 of 8.8 nM and 5-HT2 receptor with an IC50 of 8.6 nM. Tefludazine moderately inhibits the uptake of dopamine, norepinephrine and serotonin in rat brain synaptosomes, with IC50 values of 520 nM, 660 nM and 7000 nM, respectively . Tefludazine exhibits long-acting antipsychotic activity, lacks anticholinergic activity, shows Clozapine (HY-14539)-like effects at low doses and Haloperidol (HY-14538)-like effects at high doses. Tefludazine can be used for the research of psychotic disorders .
Cat. No.: HY-187708
CAS No.: 80349-58-2
Target:
Research Areas:
Panuramine is a blood-brain barrier permeable, orally active selective 5-HT Receptor antagonist with an IC50 of 22 nM. Panuramine prevents 5-HT reuptake through non-competitive antagonism of 5-HT Receptor, but does not affect dopamine uptake. Panuramine can be used for research on depression .
Cat. No.: HY-W380450A
CAS No.: 52730-46-8
Synonyms: (S)-Viloxazin; (S)-Emovit
Target:
Research Areas:
(S)-Viloxazine ((S)-Viloxazin) is the more pharmacologically active isomer of Viloxazine (HY-W380450). (S)-Viloxazine is an orally active, blood-brain barrier penetrant norepinephrine transporter inhibitor. It also acts as a 5-HT2C receptor agonist and a 5-HT2B receptor inhibitor. (S)-Viloxazine modulates serotonergic and noradrenergic activities, blocks norepinephrine reuptake, and elevates extracellular levels of serotonin, norepinephrine and dopamine in the prefrontal cortex, without inhibiting 5-HT or dopamine uptake into synaptosomes. (S)-Viloxazine can be used in research related to attention deficit hyperactivity disorder and depression .
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
