80349-58-2
80349-58-2
Chemical Structure
Panuramine
- CAS No.: 80349-58-2
- Formula:C24H25N3O2
- Molecular Weight:387.47
InChIKey: AQFFJGJVFJCQQL-UHFFFAOYSA-N
SMILES: O=C(NC1CCN(CC1)CC2=CC3=C(C=CC=C3)C=C2)NC(C4=CC=CC=C4)=O
Biological Activity: Panuramine is a blood-brain barrier permeable, orally active selective 5-HT Receptor antagonist with an IC50 of 22 nM. Panuramine prevents 5-HT reuptake through non-competitive antagonism of 5-HT Receptor, but does not affect dopamine uptake. Panuramine can be used for research on depression[1][2].
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Panuramine | Panuramine is a blood-brain barrier permeable, orally active selective 5-HT Receptor antagonist with an IC50 of 22 nM. Panuramine prevents 5-HT reuptake through non-competitive antagonism of 5-HT Receptor, but does not affect dopamine uptake. Panuramine can be used for research on depression. | |||||||||||||||||||||
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References
- [1]. Blurton PA, et al. Panuramine, a selective inhibitor of uptake of 5-hydroxytryptamine in the brain of the rat. Neuropharmacology. 1984 Sep;23(9):1049-52.
- [2]. KURBAT N M, et al. Neuropharmacological activity of piperidine derivatives (a review). Pharmaceutical Chemistry Journal, 1991, 25(7): 450-462.
