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Referencia número: HY-W380450A

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(S)-Viloxazine

Name: (S)-Viloxazine
Brand: MedChemExpress
SKU: HY-W380450A
Availability: PreOrder

(Synonyms: (S)-Viloxazin; (S)-Emovit)

(S)-Viloxazine ((S)-Viloxazin) is the more pharmacologically active isomer of Viloxazine (HY-W380450). (S)-Viloxazine is an orally active, blood-brain barrier penetrant norepinephrine transporter inhibitor. It also acts as a 5-HT2C receptor agonist and a 5-HT2B receptor inhibitor. (S)-Viloxazine modulates serotonergic and noradrenergic activities, blocks norepinephrine reuptake, and elevates extracellular levels of serotonin, norepinephrine and dopamine in the prefrontal cortex, without inhibiting 5-HT or dopamine uptake into synaptosomes. (S)-Viloxazine can be used in research related to attention deficit hyperactivity disorder and depression.

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No. CAS: 52730-46-8
Fòrmula: C₁₃H₁₉NO₃
Peso molecular:237.29

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

(S)-Viloxazine Chemical Structure

No. CAS: 52730-46-8

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Descripciòn

IC₅₀ & Target

^[1]^[2]^[3]^[4]

norepinephrine transporter

5-HT_2C Receptor

5-HT_2B Receptor

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In Vitro

(S)-Viloxazine ((S)-Viloxazin) (concentrations to determine IC₅₀; 5 min pre-incubation, 5 min incubation with tritiated noradrenaline) inhibits noradrenaline uptake into rat hypothalamic synaptosomes with an IC₅₀ of 0.38 μM^[4].
(S)-Viloxazine (>10 μM; 5 min pre-incubation, 5 min incubation with tritiated amine) does not inhibit 5-HT uptake into rat hypothalamic synaptosomes or dopamine uptake into rat striatal synaptosomes at concentrations up to >10 μM^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

(S)-Viloxazine ((S)-Viloxazin) (1.9 mg/kg; s.c.; single dose) inhibits noradrenaline uptake into mouse heart in vivo with an ED₅₀ of 1.9 mg/kg s.c^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

unspecified strain^[4]
Dosage:

1.9 mg/kg
Administration:

s.c.; single dose
Result:

Demonstrated an ED₅₀ of 1.9 mg/kg s.c. for inhibition of [³H]l-noradrenaline uptake into mouse heart in vivo.

Chemical Information

No. CAS 52730-46-8
Peso molecular 237.29
Fòrmula C₁₃H₁₉NO₃
SMILES

CCOC1=C(OC[C@H]2OCCNC2)C=CC=C1
Synonyms

(S)-Viloxazin; (S)-Emovit
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Yu C, et al. New Insights into the Mechanism of Action of Viloxazine: Serotonin and Norepinephrine Modulating Properties. Journal of experimental pharmacology. 2020;12:285-300. [Content Brief]

[2]. Edinoff AN, et al. Viloxazine in the Treatment of Attention Deficit Hyperactivity Disorder. Front Psychiatry. 2021 Dec 17;12:789982.

[3]. Findling RL, et al. Viloxazine Extended-Release Capsules in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: Results of a Long-Term, Phase 3, Open-Label Extension Trial. CNS drugs. 2025 Nov;39(11):1157-1172.

[4]. Blackburn TP, et al. Effects of viloxazine, its optical isomers and its major metabolites on biogenic amine uptake mechanisms in vitro and in vivo. European journal of pharmacology. 1978 Dec 01;52(3-4):367-74.

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1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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(S)-Viloxazine

Ver todos los productos específicos de isoformas Adrenergic Receptor

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