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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
29 Results for "
effective substrate
" in MedChemExpress (MCE) Product Catalog:
Products (29)
29 Results for "effective substrate" in MCE Product Catalog:
Cat. No.: HY-100875R
CAS No.: 78186-34-2
Synonyms: CL216942 (Standard)
Target:
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Bisantrene (Standard) is the analytical standard of Bisantrene. This product is intended for research and analytical applications. Bisantrene is a highly effective antitumor agent, it exerts its cytotoxicity by affecting DNA intercalation. Bisantrene targets eukaryotic type II topoisomerases. Bisantrene is a substrate of MDR1 .
Cat. No.: HY-162654
CAS No.: 55909-92-7
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FXIIIa-IN-1 (Compound 16) is a potent and selective FXIIIa (Factor XIIIa) inhibitor with an IC50 value of 2.4 μM. FXIIIa-IN-1 inhibits FXIIIa by competing with the Gln-donor protein substrate (dimethylcasein). FXIIIa-IN-1 holds promise for the development of effective and safe novel anticoagulants .
Cat. No.: HY-111338R
CAS No.: 321-64-2
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Tacrine (Standard) is the analytical standard of Tacrine. This product is intended for research and analytical applications. Tacrine is an effective oral acetylcholine (AChE) inhibitor (IC50 = 109 nM) and also acts as an active substrate for CYP1A2. Tacrine can restore cognitive dysfunction in elderly rats. Tacrine can cause liver toxicity and is used in research related to Alzheimer's disease .
Cat. No.: HY-164997
CAS No.: 21562-58-3
Synonyms: 15-keto PGF1α
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15-keto Prostaglandin F1α (15-keto PGF1α) is a prostaglandin F1α metabolite. 15-keto Prostaglandin F1α (15-keto PGF1α) is an effective substrate for PGR-2. 15-keto Prostaglandin F1α (15-keto PGF1α) can be used to study physiological processes such as prostaglandin metabolism and lipogenesis .
Cat. No.: HY-110137R
CAS No.: 55368-40-6
Synonyms: DB75 dihydrochloride (Standard); NSC 305831 dihydrochloride (Standard)
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Furamidine (dihydrochloride) (Standard) is the analytical standard of Furamidine (dihydrochloride). This product is intended for research and analytical applications. Furamidine dihydrochloride (DB75 dihydrochloride) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine dihydrochloride is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 μM, 283 μM, and >400 μM, respectively). Furamidine dihydrochloride is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine dihydrochloride is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine dihydrochloride is also an antiparasite agent .
Cat. No.: HY-117086
CAS No.: 1953156-61-0
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GSK065 is a KMO inhibitor with an IC50 of 2.5 nM and a Ki of 0.05 nM. GSK065 prevents the effective binding of NADPH to its substrate. GSK065 can be used in studies related to multiple organ dysfunction syndrome associated with acute pancreatitis .
Cat. No.: HY-100875AR
CAS No.: 71439-68-4
Synonyms: CL-216942 dihydrochloride (Standard)
Target:
Research Areas:
Bisantrene (dihydrochloride) (Standard) is the analytical standard of Bisantrene (dihydrochloride) (HY-100875A). This product is intended for research and analytical applications. Bisantrene dihydrochloride is a highly effective antitumor agent, it exerts its cytotoxicity by affecting DNA intercalation. Bisantrene dihydrochloride targets eukaryotic type II topoisomerases. Bisantrene dihydrochloride is a substrate of MDR1 .
Cat. No.: HY-108544R
CAS No.: 3519-82-2
Synonyms: Triptycene-1,4-quinone (Standard)
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INCA-6 (Standard) is the analytical standard of INCA-6 (HY-108544). This product is intended for research and analytical applications. INCA-6 (Triptycene-1,4-quinone) is a cell-permeable NFAT inhibitor. INCA-6 specifically blocks targeting of NFAT(P) substrate to the calcineurin (CN) phosphatase site and is an effective inhibitor of CN-NFAT signaling .
Cat. No.: HY-179488
CAS No.: 184488-44-6
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(±)8(9)-EET is one of the main metabolites produced by the metabolism of arachidonic acid (HY-109590) through the cytochrome P450 epoxide pathway. (±)8(9)-EET is an effective substrate for COX-1 and COX-2. (±)8(9)-EET activates PPARα in HEK293 cells and inhibits the activity of NF-κB induced by IL-1β in a PPARα-dependent and -independent manner. The (8S,9R)-isomer of (±)8(9)-EET ([(8S,9R)-EET]) causes vasoconstriction, thereby reducing renal plasma flow and glomerular filtration rate .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
