FXIIIa-IN-1
FXIIIa-IN-1 (Compound 16) is a potent and selective FXIIIa (Factor XIIIa) inhibitor with an IC50 value of 2.4 μM. FXIIIa-IN-1 inhibits FXIIIa by competing with the Gln-donor protein substrate (dimethylcasein). FXIIIa-IN-1 holds promise for the development of effective and safe novel anticoagulants.
For research use only. We do not sell to patients.
- CAS No.: 55909-92-7
- Formula: C26H25N5O19S6
- Molecular Weight:903.89
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 2.4 μM (Factor XIIIa)[1]; IC50: > 150 μM (Factor XIa)[1]; IC50: > 500 μM (Factor Xa)[1]; IC50: > 500 μM (Thrombin)[1];
FXIIIa-IN-1 (10 μM, 3 days) shows no significant cytotoxicity in breast (MCF-7 cells), intestinal (CaCo-2 cells), and kidney (HEK-293 cells) cell lines[1]. FXIIIa-IN-1 (5-2000 μM, 24 h) inhibits FXIIIa-mediated fibrin (ogen) polymerization and γ-γ dimer formation in a concentration-dependent manner[1]. FXIIIa-IN-1 (5 μL, 5 min) does not affect other clotting factors (thrombin, factor Xa, factor XIa) and is selective for FXIIIa[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 cells, HEK-293 cells, CaCo-2 cells
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Concentration:10 μM
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Incubation Time:3 days
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Result:Did not significantly affect the proliferation of MCF-7 cells, HEK-293 cells, and CaCo-2 cells.
Chemical Information
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CAS No. 55909-92-7
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Molecular Weight 903.89
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Formula C26H25N5O19S6
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SMILES
NC1=C2C(O)=C(/N=N/C3=CC=C(S(=O)(CCOS(=O)(O)=O)=O)C=C3)C(S(=O)(O)=O)=CC2=CC(S(=O)(O)=O)=C1/N=N/C4=CC=C(S(=O)(CCOS(=O)(O)=O)=O)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FXIIIa-IN-1 Related Classifications
HY-162654 Related Classifications
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