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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
43 Results for "
export
" in MedChemExpress (MCE) Product Catalog:
Products (43)
43 Results for "export" in MCE Product Catalog:
Cat. No.: HY-P4084A
Target:
Research Areas:
Cat. No.: HY-W064918
CAS No.: 1473450-60-0
NITD-304 is an orally active anti-tuberculosis agent. NITD-304 exerts inhibitory and bactericidal activities gainst Mycobacterium tuberculosis and multidrug-resistant Mycobacterium tuberculosis. NITD-304 inhibits mycobacterial cell wall biosynthesis and demonstrates synergistic or additive growth inhibitory activity with select antibacterial agents. NITD-304 shows low risk of cardiotoxicity and drug-drug interactions, with no inhibition of major cytochrome P-450 enzymes or hERG channel. NITD-304 can be used for the research of tuberculosis and multidrug-resistant tuberculosis .
Cat. No.: HY-N0193S
CAS No.: 1316303-44-2
Cat. No.: HY-N0193S1
CAS No.: 1316753-15-7
Cat. No.: HY-155972
CAS No.: 3032506-80-9
CRM1-IN-1 (Compound KL1) is a noncovalent CRM1 inhibitor. CRM1-IN-1 induces nuclear CRM1 degradation (IC50: 0.27 μM). CRM1-IN-1 inhibits CRM1-mediated nuclear export and cell proliferation, and triggers apoptosis in colorectal cancer cells .
Cat. No.: HY-N0468R
CAS No.: 63279-13-0
Category:
Cat. No.: HY-155972A
CAS No.: 3032506-81-0
CRM1-IN-2 (Compound KL2) is a noncovalent CRM1 inhibitor. CRM1-IN-2 localizes CRM1 in the nuclear periphery, depletes nuclear CRM1, and inhibits CRM1-mediated nuclear export. CRM1-IN-2 inhibits growth of colorectal cancer cells, and induces apoptosis .
Cat. No.: HY-156288
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Research Areas:
Anti-Influenza agent 5 (Compound IIB-2), chalcone-like derivative, is an influenza nuclear export inhibitor. Anti-Influenza agent 5 has inhibitory effects on oseltamivir-resistant strains. Anti-Influenza agent 5 can impede virus proliferation by blocking the export of influenza virus nucleoprotein .
Cat. No.: HY-P5344
Synonyms: Fluorigenic PEXEL peptide
Cat. No.: HY-111026
CAS No.: 950381-32-5
Target:
Research Areas:
PPQ-581 is an anti-influenza agent with an EC50 of 1 μM for preventing virus-induced cytopathic effects. PPQ-581 inhibits viral protein synthesis. PPQ-581 blocks the RNP nuclear export and cytoplasmic RNP aggregation .
Cat. No.: HY-W127487
CAS No.: 479050-96-9
Cat. No.: HY-16909R
CAS No.: 87081-35-4
Synonyms: CI 940 (Standard); LMB (Standard)
Target:
Leptomycin B (Standard) is the analytical standard of Leptomycin B (HY-16909). This product is intended for research and analytical applications. Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocKing the eukaryotic cell cycle .
Cat. No.: HY-183235
CAS No.: 1076234-33-7
NS-0011 is a CDK5 inhibitor with a Kd value of 16 μM. NS-0011 binds to the nuclear export signal domain of CDK5, disrupts its interaction with CRM-1 and increases the accumulation of CDK5 in the nucleus. NS-0011 inhibits the proliferation of gastric cancer cells. NS-0011 suppresses the occurrence of gastric cancer xenograft tumors. NS-0011 is applicable to gastric cancer-related research .
Cat. No.: HY-E71227
Target:
Research Areas:
α-Factor-transporting ATPase (EC 7.4.2.7) is a plasma membrane ATP-binding cassette (ABC) transporter that actively exports the farnesylated lipopeptide mating pheromone a-factor from the cytosol of MATa haploid cells.
Cat. No.: HY-P2801A
Target:
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Glucose-6-Phosphatase, Rabbit (EC 3.1.3.9) is an enzyme that hydrolyzes glucose-6-phosphate, resulting in the creation of a phosphate group and free glucose. Glucose is then exported from the cell via glucose transporter membrane proteins.
Cat. No.: HY-187684
CAS No.: 3054389-11-3
Research Areas:
FR-027 is an orally active, blood-brain barrier permeable XPO1 inhibitor with an EC50 value of 54-69 nM in human cells. FR-027 covalently modifies Cys528 of XPO1 via nucleophilic aromatic substitution, maintaining the nuclear export signal binding groove of XPO1 in a closed conformation to block the nuclear export process, and inhibits XPO1 function without inducing its protein degradation. FR-027 promotes cancer cell apoptosis and inhibits the growth of hematological and solid tumor cells. FR-027 can be used in research related to acute lymphoblastic leukemia, ovarian cancer, glioblastoma, and primary central nervous system lymphoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
