68 Results for "

C terminus

" in MedChemExpress (MCE) Product Catalog:
Products (68)

68 Results for "C terminus" in MCE Product Catalog:

Cat. No.: HY-P991676
CAS No.: 2418159-10-9
Synonyms: DS-2325A

Target:  

Kallikrein

Research Areas:  

Inflammation/Immunology

Eflumenibep alfa is a Kallikrein 5 inhibitor with anti-inflammatory activity. Eflumenibep alfa is a fusion protein that combines human SPINK2 with the human IgG1 Fc fragment at the C-terminus .
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Cat. No.: HY-P991678
CAS No.: 2996895-52-2
Synonyms: XENP-27564; XMAB-27564

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Efpixileukin alfa is a fusion protein that combines human IL-2 variant fused at the C-terminus to human immunoglobulin G1 (IgG1) Fc fragment. Efpixileukin alfa is an immunomodulator .
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Cat. No.: HY-P10055
CAS No.: 2042750-71-8
Synonyms: PSMA-1
Target:  

PSMA

Research Areas:  

Cancer

PSMA-1 is a PSMA targeting peptide (GRFLTGGTGRLLRIS) and can be used for for targeted delivery of glucose-regulated protein (GRP)-silencing siRNAs in PCa cells. PSMA-1 is selected and polyarginine sequences R6 or R9 were added at the C terminus to generate the CTPs. FITC labeling of the peptide with an aminohexanoic acid (Ahx) linker at the N terminus produced FITC-PSMA-1,to track PSMA binding on PCa cells .
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Cat. No.: HY-172193
Synonyms: SGC-UBD1031
Target:  

Deubiquitinase HDAC

Research Areas:  

Inflammation/Immunology Cancer

UBD1031 (SGC-UBD1031) is a selective USP16/HDAC6-UBD antagonist with a human USP16-UBD IC50 of 10.6 μM, KD value of 48 nM, and a human HDAC6-UBD KD of 16 nM. UBD1031 disrupts ISG15 C-terminus interactions with USP16-UBD and HDAC6-UBD, and exhibits cooperative inhibition of full-length USP16 deubiquitinase activity via USP16-UBD binding. UBD1031 can be used in research on cancer, autoimmune diseases, and Down syndrome .
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Cat. No.: HY-P99963
CAS No.: 2387417-06-1
Synonyms: HS636

Target:  

PD-1/PD-L1

Research Areas:  

Cancer

Sudubrilimab (HS636) is an Ig G1-kappa monoclonal antibody against PDL1. Sudubrilimab is fused at the C terminus of the heavy chain to a TGF-β1 receptor Ⅱ ectodomain (TGFBR2-ECD), and which can sequester the PD-1/PD-L1 pathway and TGF-β bioactivity in the immunosuppressive tumor microenvironment .
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Cat. No.: HY-P4807
CAS No.: 122071-54-9
Synonyms: Hez-PBAN
Target:  

Inhibitory Antibodies

Research Areas:  

Neurological Disease

Pheromone Biosynthesis Activating Neuropeptide (Helicoverpa assulta, Heliothis zea) (PBAN), a member of the PBAN/Pyrokinin neuropeptide family, characterized by a common amino acid sequence FXPRLamide motif in the C-terminus .
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Cat. No.: HY-P991680
CAS No.: 3037408-21-9

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

Elipunercept is a fusion protein that combines human TNFRSF1B extracellular domain fragment (1-235) fused at the C-terminus to a human IgG1 Fc fragment. Elipunercept is an immunomodulator .
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Cat. No.: HY-P10993
CAS No.: 1407967-57-0
Target:  

Bcl-2 Family

Research Areas:  

Cancer

CT20p is an anticancer peptide based on the C hydrophobic terminus of Bax. CT20p has a unique cytotoxic effect independent of full-length Bax, and can act on mitochondria, leading to fusion-like aggregation and mitochondrial membrane hyperpolarization. CT20p can reduce α5β1 integrin levels and inhibit F-actin polymerization, thereby destroying the cytoskeleton and preventing cell attachment. CT20p can be used in the study of breast cancer .
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Cat. No.: HY-P1321
CAS No.: 158859-98-4
Synonyms: 1229U91; GW1229
Research Areas:  

Neurological Disease

GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide Y Y receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pKi= 8.8) .
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Cat. No.: HY-P3102A
Target:  

GCGR

Research Areas:  

Metabolic Disease

GLP-1(32-36)amide TFA, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide TFA could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice .
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Cat. No.: HY-P1505
CAS No.: 63555-63-5
Synonyms: Complement 3a (70-77)
Target:  

Complement System

Research Areas:  

Inflammation/Immunology

C3a (70-77) is an octapeptide corresponding to the COOH terminus of C3a, exhibits the specificity and 1 to 2% biologic activities of C3a.
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Cat. No.: HY-P1735
CAS No.: 108273-68-3
Target:  

Cytochrome P450

Research Areas:  

Inflammation/Immunology

Moth Cytochrome C (MCC) (88-103), derived from the carboxyl terminus of moth cytochrome c, induces positive selection of TCR transgenic thymocytes .
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Cat. No.: HY-P11104
CAS No.: 166275-64-5
Target:  

Inhibitory Antibodies

Research Areas:  

Others

SsrA tag is an 11-aa peptide added to the C-terminus of proteins stalled during translation, targeting them for degradation by ClpXP and ClpAP .
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Cat. No.: HY-P1367
Target:  

Inhibitory Antibodies

Research Areas:  

Neurological Disease

Pep1-TGL is a synthetic peptide containing the TGL motif from the C-terminus of the AMPA receptor GluA1 subunit .
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Cat. No.: HY-P3891
CAS No.: 53749-60-3
Target:  

Neurokinin Receptor

Research Areas:  

Neurological Disease

Substance P (4-11), the C-terminus fragment of Substance P (HY-P0201), is a Substance P agonist that shows highly selective for NK1 receptors .
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Cat. No.: HY-P2019
CAS No.: 114281-19-5
Research Areas:  

Neurological Disease

Levitide is a neurohormone-like peptide, can be isolated from skin secretions of the South African frog Xenopus laevis. Levitide comes from preprolevitide, is 88 residues long and contains contains the levitide peptide at the C terminus (Glu-Gly-Met-Ile-Gly-Thr-Leu-Thr-Ser-Lys-Arg-Ile-Lys-Gln-NH2) and the putative signal sequence at the N terminus .
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Cat. No.: HY-P10247
CAS No.: 201293-38-1
Research Areas:  

Neurological Disease

Amyloid precursor C-terminal peptide is cleaved from the C-terminus of Amyloid Precursor Protein (APP). Amyloid precursor C-terminal peptide accumulation causes mitochondrial morphology alteration and basal mitophagy failure, which indicates that amyloid precursor protein C-terminal peptide may correspond to an etiological trigger of Alzheimer’s disease (AD) pathology .
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Cat. No.: HY-P10161
CAS No.: 907589-02-0
Research Areas:  

Others

Ac-DMQD-pNA is a peptide substrate. Both of the recombinant CgCaspase-1 (rCgCaspase-1) and the C-terminus of CgCaspase-1 (rCgCaspase-1-C) exhibits similar caspase activity towards proteolytic substrate Ac-DMQD-pNA and Ac-DEVD-pNA (HY-P1006) .
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Cat. No.: HY-P3932
Target:  

Neurokinin Receptor

Research Areas:  

Neurological Disease

[Sar4] Substance P (4-11) is an analog of Substance P (4-11). Substance P (4-11), the C-terminus fragment of Substance P (HY-P0201), is a Substance P agonist .
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Cat. No.: HY-P5509
CAS No.: 230968-98-6
Target:  

Inhibitory Antibodies

Research Areas:  

Others

C5aR1 antagonist peptide is a biological active peptide. (This linear peptide is derived from the C-terminus of the chemokine, complement fragment 5 anaphylatoxin (C5a). This peptide functions to inhibit C5a binding and function at human and rat C5a receptors. C5a is crucial to triggering cellular immune responses and its overexpression is involved in arthritis, Alzheimer’s disease, cystic fibrosis, systemic lupus erythematosus, and other immunoinflammatory diseases.)
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