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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
45 Results for "
hydroxyglutarate
" in MedChemExpress (MCE) Product Catalog:
Products (45)
45 Results for "hydroxyglutarate" in MCE Product Catalog:
Cat. No.: HY-P3100
CAS No.: 939960-34-6
Cat. No.: HY-125357
CAS No.: 148619-41-4
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Cat. No.: HY-120765
CAS No.: 1304750-47-7
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BRD2879 is a potent IDH1-R132H inhibitor with IC50 values of 0.05, 2.5, >20, >20 µM for IDH1-R132H, IDH1-R132C, IDH1-WT, IDH2-R140Q, respectively. BRD2879 reduces (R)-2-hydroxyglutarate (R-2HG) levels .
Cat. No.: HY-175213
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Mutant IDH1-IN-7 is a highly selective Isocitrate Dehydrogenase 1 (IDH1) R132H (IC50 = 0.26 μM, Kd = 2.1 μM)/R132C (IC50 = 1.1 μM) inhibitor. Mutant IDH1-IN-7 has no inhibitory effect on wild-type IDH1, IDH2-wt, and IDH2 R140Q. Mutant IDH1-IN-7 inhibits 2-Hydroxyglutarate (2-HG) production in U87-MG R132H cells (EC50 = 0.55 μM). Mutant IDH1-IN-7 exhibits moderate antiproliferative effects on U87-MG R132H and HT-1080 cells .
Cat. No.: HY-149359
CAS No.: 3049485-80-2
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IHMT-IDH1-053 (compound 16) is a highly selectivity and irreversible IDH1-mutant inhibitor with an IC50 of 4.7 nM for IDH1 R132H. IHMT-IDH1-053 displays high selectivity against IDH1 mutants over IDH1 wt and IDH2 wt/mutants. IHMT-IDH1-053 inhibits 2-hydroxyglutarate (2-HG) production in IDH1 R132H mutant transfected 293T cells (IC50=28 nM). IHMT-IDH1-053 binds to the IDH1 R132H protein in the allosteric pocket adjacent to the NAPDH binding pocket through a covalent bond with residue Cys269. IHMT-IDH1-053 inhibits the proliferation of HT1080 cell line and primary AML cells which both bear IDH1 R132 mutants .
Cat. No.: HY-158104
Cat. No.: HY-103641R
CAS No.: 1391194-67-4
Synonyms: (2R)-Octyl-2-HG (Standard)
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(2R)-Octyl-α-hydroxyglutarate (Standard) is the analytical standard of (2R)-Octyl-α-hydroxyglutarate. This product is intended for research and analytical applications. (2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a modified form of D-isomer 2-Hydroxyglutarate.
Cat. No.: HY-103641AS1
CAS No.: 2748638-78-8
Synonyms: (2R)-Octyl-2-HG-d17
Cat. No.: HY-100542R
CAS No.: 103404-90-6
Synonyms: Disodium (R)-2-hydroxyglutarate (Standard)
Cat. No.: HY-164542
CAS No.: 2071196-10-4
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TQ05310 is an orally available inhibitor of IDH2 mutants, targeting both IDH2-R140Q (IC50=136.9 nM) and IDH2-R172K (IC50=37.9 nM) mutants. TQ05310 inhibits the production of 2-hydroxyglutarate (2-HG) and induces differentiation of cells expressing IDH2-R140Q and IDH2-R172K by inhibiting the enzymatic activity of mutant IDH2. TQ05310 can be used for the study of acute myeloid leukemia .
Cat. No.: HY-164526
CAS No.: 2376068-96-9
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SH1573 is an orally active mIDH2 inhibitor. SH1573 has a strong and selective inhibitory effect on mIDH2 R140Q protein (IC50=4.78 nmol/L), and can effectively reduce the production of the carcinogenic metabolite 2-hydroxyglutarate (2-HG) in animal models, cell lines, serum and tumors. SH1573 can be used for the study of acute myeloid leukemia (AML) .
Cat. No.: HY-103641AR
CAS No.: 1391194-64-1
Synonyms: (2S)-Octyl-2-HG (Standard)
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CVT-2738 (Standard) is the analytical standard of CVT-2738. This product is intended for research and analytical applications. CVT-2738 is a Ranolazine (HY-B0280) Metabolite, and shows anti-myocardial ischemia activities .
Cat. No.: HY-W704805
Cat. No.: HY-W779800
CAS No.: 1648909-80-1
Cat. No.: HY-143234
CAS No.: 2757155-96-5
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mIDH1-IN-1 (compound 43) is a potent and selective mIDH1 (mutant isocitrate dehydrogenases 1) inhibitor, with an IC50 of 961.5 nM. mIDH1-IN-1 potently inhibits intracellular 2-HG (2-hydroxyglutarate) production in HT1080 cells, with an EC50 of 208.6 ± 8.0 nM. mIDH1-IN-1 shows a significant anti-proliferation activity on IDH1 mutant-U-87 cells, with an IC50 of 41.8 nM. mIDH1-IN-1 is an antitumor agent, and can be used for IDH1 mutated solid tumors research .
Cat. No.: HY-113038AR
CAS No.: 40951-21-1
Synonyms: 2-hydroxyglutarate disodium (Standard); 2-Hydroxyglutaric acid disodium (Standard); 2-Hydroxypentanedioic acid disodium (Standard)
Cat. No.: HY-112289B
CAS No.: 1429179-08-7
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(1R)-IDH889 is the isomer of IDH889 (HY-112289), and can be used as an experimental control. IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC50s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1 R132H, IDH1 R132C and IDH1 wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC50 of 0.014 μM .
Cat. No.: HY-E71561
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2-Hydroxyglutarate synthase (EC 2.3.3.11) belongs to the family of transferases, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer.
Cat. No.: HY-E71043
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D-2-Hydroxyglutarate Dehydrogenase, Acidaminococcus fermentans (EC 1.1.99.39) is a special NAD-dependent enzyme which reacts with D2HG specifically and converts D-2-hydroxyglutarate (D2HG) to α-ketoglutarate.
Cat. No.: HY-E71609
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2-Oxoglutarate reductase (EC 1.1.1.399) is an oxidoreductase that catalyzes the reversible interconversion between 2-hydroxyglutarate (2-HG) and 2-oxoglutarate (also known as α-ketoglutarate, α-KG).
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
