SH1573
SH1573 is an orally active mIDH2 inhibitor. SH1573 has a strong and selective inhibitory effect on mIDH2 R140Q protein (IC50=4.78 nmol/L), and can effectively reduce the production of the carcinogenic metabolite 2-hydroxyglutarate (2-HG) in animal models, cell lines, serum and tumors. SH1573 can be used for the study of acute myeloid leukemia (AML).
For research use only. We do not sell to patients.
- CAS No.: 2376068-96-9
- Formula: C21H18F9N7O4S
- Molecular Weight:635.46
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS No. 2376068-96-9
-
Molecular Weight 635.46
-
Formula C21H18F9N7O4S
-
SMILES
FC(F)(F)C1=CC=CC(C2=NC(N3C[C@@](C(F)(F)F)(O)CC3)=NC(NC4=CC(C(F)(F)F)=NC=C4)=N2)=N1.CS(O)(=O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SH1573 Related Classifications
HY-164526 Related Classifications
Powered by Bioz