107 Results for "

classical

" in MedChemExpress (MCE) Product Catalog:
Products (107)

107 Results for "classical" in MCE Product Catalog:

Cat. No.: HY-U00155
CAS No.: 56605-16-4
Synonyms: NSC172112; NSC268497
Research Areas:  

Cancer

NCI172112 is a classical bifunctional alkylating agent synthesized in an effort to develop antitumor agents effective against CNS tumors.
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Cat. No.: HY-145686
CAS No.: 1107710-62-2
Purity:  99.31%
AV023 is a potent inhibitor of ANKRD22. AV023 promotes the expansion of gastrointestinal mucosal epithelial stem cells and indirectly activates the Wnt classical pathway, which helps the recovery of damaged gastrointestinal mucosal tissues in the body (extracted from patent CN111205231B) .
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Cat. No.: HY-123410
CAS No.: 628263-22-9
Target:  

Cannabinoid Receptor

Research Areas:  

Cancer

KM-233 is a classical cannabinoid with good blood brain barrier penetration. KM-233 possesses a selective affinity for the CB2 receptors relative to THC. KM-233 is effective at reducing U87 glioma tumor burden, and can be used for glioma research .
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Cat. No.: HY-E70852
Target:  

PKC

Research Areas:  

Cancer

PKC is a family of serine/threonine kinases involved in several processes including proliferation, differentiation, apoptosis, and migration. PKCα is a classical PKC isoform that contains a C1 domain that binds to diacylglycerol (DAG). PKCα Recombinant Human Active Protein Kinase is a recombinant PKCα protein that can be used to study PKCα-related functions .
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Cat. No.: HY-P10600
CAS No.: 1105053-46-0
Target:  

Ras

Research Areas:  

Others

BIMAX2 is a high affinity nuclear localization signal (NLS) peptide. BIMAX2 can mimic the activity of the classical nuclear localization signal (cNLS) and competitively bind to importin α, thereby inhibiting the binding of cNLS-cargo proteins to importin α. BIMAX2 can be used to study the role of RBBP4 in regulating nuclear import efficiency and cell senescence .
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Cat. No.: HY-13225
CAS No.: 220662-95-3
Synonyms: RJR-2403 oxalate; (E)-Metanicotine oxalate
Target:  

nAChR

Research Areas:  

Neurological Disease

Rivanicline (RJR-2403) oxalate is a neuronal nicotinic receptor agonist. Rivanicline oxalate is highly selective for the rat brain cortex nAChRs (Ki = 26 nM, EC50 of 732 nM) and α4β2 subtype (Ki = 26 nM, EC50 = 16 μM). Rivanicline oxalate can significantly restore the learning impairment and cognitive dysfunction. Rivanicline oxalate can be used for the study of neurodegenerative diseases (such as schizophrenia or Alzheimer's disease) .
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Cat. No.: HY-179373
UB-MBX-46 is a potent and selective P2X7 receptor antagonist with IC50s of 0.514 nM (hP2X7R), 40.6 nM (rP2X7R), and 4.52 nM (mP2X7R), respectively. UB-MBX-46 interacts with the classical allosteric pocket of the human P2X7 receptor. UB-MBX-46 can be used for cancer, atherosclerosis, and neurode generation research .
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Cat. No.: HY-P99048A
Synonyms: IBI308 (Anti-PD-1)

Target:  

PD-1/PD-L1

Research Areas:  

Inflammation/Immunology Cancer

Sintilimab (Anti-PD-1) (IBI308 (Anti-PD-1)) is a safe and effectivel humanized IgG4 monoclonal antibody that binds to PD-1 with a KD value of 74 pM. Sintilimab (Anti-PD-1) blocks the interaction of PD-1 with its ligands (PD-L1 and PL-L2), consequently helping to restore the endogenous antitumour T-cell response. Sintilimab (Anti-PD-1) combined with prebiotics inhibits tumor volume and regulates immune cell subpopulation balance in lung adenocarcinoma mice. Sintilimab (Anti-PD-1) can be used for the research of classical Hodgkin's lymphoma, non-small cell lung cancer and oesophageal cancer .
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Cat. No.: HY-174735
Target:  

mRNA

Research Areas:  

Cancer

Human CDH5 mRNA encodes the human cadherin 5 (CDH5) protein, a classical cadherin of the cadherin superfamily. CDH5 functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner. It plays a role in endothelial adherens junction assembly and maintenance.
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Cat. No.: HY-106785
CAS No.: 107023-41-6
Synonyms: SKF-104353; SK&F-104353
Target:  

Leukotriene Receptor

Research Areas:  

Inflammation/Immunology

Pobilukast is a classical CysLT1 receptor antagonist. Pobilukast can be used for the research of asthma .
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Cat. No.: HY-U00155R
CAS No.: 56605-16-4
Synonyms: NSC172112 (Standard); NSC268497 (Standard)
Research Areas:  

Cancer

NCI172112 is a classical bifunctional alkylating agent synthesized in an effort to develop antitumor agents effective against CNS tumors.
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Cat. No.: HY-N12265
CAS No.: 108885-62-7
Versicolactone B is a sesquiterpene that can be isolated from Viola yedoensis. Versicolactone B exhibits anti-complement activity against the classical pathway and the alternative pathway .
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Cat. No.: HY-P990716
CAS No.: 2648346-74-9
Synonyms: AZD7789

Target:  

PD-1/PD-L1 Tim3

Research Areas:  

Inflammation/Immunology

Sabestomig (AZD7789) is a monovalent bispecific antibody targeting PD-1 and TIM-3. Sabestomig binds to PD-1 and an epitope in the TIM-3 IgV domain outside the phosphatidylserine-binding cleft, thereby precisely regulating immune responses. Sabestomig promotes IL-2 production, efferocytosis and cross-presentation of tumor antigens, and enhances the release of anti-tumor T cell cytokines, cytotoxicity, and secretion of IFN-γ. Sabestomig inhibits the growth of solid tumors, prolongs the duration of tumor suppression, and significantly enhances anti-tumor responses following anti-PD-1 therapy. Sabestomig has been used in studies related to non-small cell lung cancer and classical Hodgkin lymphoma .
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Cat. No.: HY-146753
CAS No.: 2758387-58-3
Target:  

HIV

Research Areas:  

Infection

HIV-1 inhibitor-20 is a potent HIV-1 inhibitor by non-classical isosteric replacement of amide to 1,2,4-oxadiazoles .
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Cat. No.: HY-163399
CAS No.: 54387-80-3
Target:  

Bacterial

Research Areas:  

Infection

Antibacterial agent 197 (compound 1-deAA) is a termination inhibitor of non-classical anhydroglycosyl receptors and anhydrowall peptide-type peptidoglycan (PG) in bacterial TGase, with activity against Staphylococcus aureus. Antibacterial agent 197 synergizes with Vancomycin (HY-B0671) and is its antibacterial adjuvant .
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Cat. No.: HY-146189
CAS No.: 2413901-61-6
Target:  

Topoisomerase Apoptosis

Research Areas:  

Cancer

Topoisomerase II inhibitor 9 (Compound 19b) is a Topo II inhibitor with an IC50 of 0.97 μM. Topoisomerase II inhibitor 9 is also a classical DNA-intercalator with an IC50 of 43.51 μM. Topoisomerase II inhibitor 9 arrests the cell cycle at the G2/M phase and induces apoptosis in Hep G‐2 cells .
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Cat. No.: HY-147735
Target:  

GABA Receptor

Research Areas:  

Neurological Disease

GABAA receptor agonist 1 (compound 3e) is a potent GABAA receptor agonist. GABAA receptor agonist 1 shows anti-depression activities in classical mouse models of depression of FST and TST. GABAA receptor agonist 1 binds at the GABA binding site of GABAA receptor in order to produce GABAergic effects. GABAA receptor agonist 1 has the potential for the research of depression .
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Cat. No.: HY-147736
Target:  

GABA Receptor

Research Areas:  

Neurological Disease

GABAA receptor agonist 2 (compound 4c) is a potent GABAA receptor agonist. GABAA receptor agonist 2 shows anti-depression activities in classical mouse models of depression of FST and TST. GABAA receptor agonist 2 binds at the GABA binding site of GABAA receptor in order to produce GABAergic effects. GABAA receptor agonist 2 has the potential for the research of depression .
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Cat. No.: HY-P5469
CAS No.: 722541-91-5
Research Areas:  

Others

WRW4-OH is a biological active peptide. (This peptide inhibits binding of one of formyl peptide receptor-like 1 (FPRL1) agonists WKYMVm to its specific receptor. FPRL1 is an important classical chemoattractant receptor that is expressed in phagocytic cells in the peripheral blood and brain. Activation of FPRL1 is closely related to inflammatory responses in the host defense mechanism and neurodegenerative disorders.)
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Cat. No.: HY-101884R
CAS No.: 576-19-2
Synonyms: (+)-Biocytin (Standard)
Biocytin (Standard) is the analytical standard of Biocytin. This product is intended for research and analytical applications. Biocytin is a conjugate of D-biotin and L-lysine, where the carboxylate of D-biotin is coupled with the -amine of L-lysine via a secondary amide bond. Biocytin is a classical neuroanatomical tracer commonly used to map brain connectivity. Biocytin is used as a versatile marker in anterograde, retrograde and intracellular neuroanatomical investigations and in biotinidase assays[1][2].
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