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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
197 Results for "
elastase
" in MedChemExpress (MCE) Product Catalog:
Products (197)
197 Results for "elastase" in MCE Product Catalog:
Art. -Nr.: HY-155231
Neutrophil elastase inhibitor 4 is a human neutrophil elastase (HNE) inhibitor with an IC50 of 21.78 nM and a Ki of 8.04 nM. Neutrophil elastase inhibitor 4 induces G2/M cell cycle arrest and apoptosis. Neutrophil elastase inhibitor 4 is applicable to research related to breast cancer, multiple myeloma and non-small cell lung cancer .
Art. -Nr.: HY-117668
CAS. Nr.: 149859-17-6
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MDL 101146 is an orally active neutrophil elastase inhibitor. MDL 101146 inhibits neutrophil elastase for human with a Ki value of 25 nM. MDL 101146 can be used for the research of arthritis .
Art. -Nr.: HY-123791
CAS. Nr.: 956907-23-6
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AZD-9819 is a neutrophil elastase (HNE) inhibitor. AZD-9819 can be used to study chronic obstructive pulmonary disease .
Synonyms: SC-39026; Declaben
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Lodelaben is a human neutrophil elastase inhibitor with an IC50 and Ki of 0.5 and 1.5 μM, respectively.
Art. -Nr.: HY-P3106
CAS. Nr.: 149695-85-2
Synonyms: (Z-Ala-Ala-Ala-Ala)2Rhodamine110; bis-CBZ-L-alanyl-L-arginine amide Rhodamine 110
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Art. -Nr.: HY-P4126
CAS. Nr.: 113277-37-5
Art. -Nr.: HY-P11337
CAS. Nr.: 403479-63-0
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Art. -Nr.: HY-P5459
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Elafin(human) is a serine protease inhibitory peptide that potently inhibits human neutrophil elastase (HLE) and human proteinase 3 (PR3). Elafin(human) forms a substrate-like, competitive and fully reversible complex with HLE at a 1:1 stoichiometric ratio, with a Ki of 0.17 nM. Elafin(human) inhibits PR3-mediated degradation of elastin-FITC, with an IC50 of 9.5 nM. Elafin(human) can be used in studies of neutrophil serine proteases, elastin degradation and inflammation-related tissue damage
Synonyms: Safflower seed oil (from Carthamus tinctorius seed)
Art. -Nr.: HY-15651A
CAS. Nr.: 1240425-05-1
Synonyms: AZD9668 tosylate
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Forschungsgebiete:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Alvelestat tosylate (AZD9668 tosylate) is an orally active, selective inhibitor of neutrophil elastase. Alvelestat tosylate reduces elastase activity, myeloperoxidase release, neutrophil recruitment and activation, and calcium phosphate precipitation; promotes smooth muscle cell colonization and collagen deposition; and inhibits the formation of neutrophil extracellular traps (NETs) as well as NET-derived neutrophil elastase activity. Alvelestat tosylate restores endothelial dysfunction, regulates antioxidant factors, improves the expression of endothelial tight junctions, reduces vascular leakage, and accelerates wound healing. Alvelestat tosylate prevents pulmonary hemorrhage, matrix protein degradation, airspace enlargement, and small airway wall remodeling; and alleviates cigarette-induced inflammatory responses. Alvelestat tosylate inhibits the growth of abdominal aortic aneurysms exacerbated by Porphyromonas gingivalis. Alvelestat tosylate can be used in research related to chronic obstructive pulmonary disease, abdominal aortic aneurysm, radiation-induced skin injury, and bronchiectasis .
Art. -Nr.: HY-15651R
CAS. Nr.: 848141-11-7
Synonyms: AZD9668 (Standard)
Forschungsgebiete:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Alvelestat (Standard) (AZD9668 (Standard)) is the analytical standard of Alvelestat (HY-15651). This product is intended for research and analytical applications. Alvelestat (AZD9668) is an orally active, selective inhibitor of neutrophil elastase. Alvelestat reduces elastase activity, myeloperoxidase release, neutrophil recruitment and activation, and calcium phosphate precipitation; promotes smooth muscle cell colonization and collagen deposition; and inhibits the formation of neutrophil extracellular traps (NETs) as well as NET-derived neutrophil elastase activity. Alvelestat restores endothelial dysfunction, regulates antioxidant factors, improves the expression of endothelial tight junctions, reduces vascular leakage, and accelerates wound healing. Alvelestat prevents pulmonary hemorrhage, matrix protein degradation, airspace enlargement, and small airway wall remodeling; and alleviates cigarette-induced inflammatory responses. Alvelestat inhibits the growth of abdominal aortic aneurysms exacerbated by Porphyromonas gingivalis. Alvelestat can be used in research related to chronic obstructive pulmonary disease, abdominal aortic aneurysm, radiation-induced skin injury, and bronchiectasis .
Art. -Nr.: HY-106293
CAS. Nr.: 105080-50-0
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ICI-200880 is a potent, selective and reversible human neutrophil elastase (HNE) inhibitor. ICI-200880 is promising for research of inflammatory lung diseases related to neutrophil elastase, such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF) .
Art. -Nr.: HY-P5374
CAS. Nr.: 125791-90-4
Art. -Nr.: HY-146070
CAS. Nr.: 678152-73-3
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Elastase-IN-1 (Compound Q11) is an elastase inhibitor with an IC50 of 0.897 µM. Elastase-IN-1 is non-toxic .
Art. -Nr.: HY-E70586
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Elastase (high purity) is a serine protease that hydrolyzes proteins and peptides.
Art. -Nr.: HY-124556
CAS. Nr.: 68112-21-0
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Elasnin is a selective granulocyte elastase inhibitor. Elasnin is almost ineffective for pancreatic elastase, trypsin, chymotrypsin, thermolysin and papain .
Art. -Nr.: HY-106448
CAS. Nr.: 94149-41-4
Synonyms: MR 889
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Forschungsgebiete:
Midesteine (MR 889) is a proteinase inhibitor that can inhibit porcine pancreatic elastase, human neutrophil elastase and bovine chymotrypsin. Midesteine has the potential for chronic obstructive pulmonary disease (COPD) and chronic bronchitis research .
Art. -Nr.: HY-N3566
CAS. Nr.: 55610-01-0
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
