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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
183 Results for "
lenalidomide
" in MedChemExpress (MCE) Product Catalog:
Products (183)
183 Results for "lenalidomide" in MCE Product Catalog:
Cat. No.: HY-W244820
CAS No.: 1010100-27-2
Target:
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Desamino lenalidomide-5-acetonitrile is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-5-acetonitrile can be linked to a target protein ligand via a linker to form a PROTAC.
Cat. No.: HY-W251343
CAS No.: 1416990-09-4
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Desamino lenalidomide-6-OH is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-6-OH can be linked to a target protein ligand via a linker to form a PROTAC.
Cat. No.: HY-W586325
CAS No.: 2171519-15-4
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Desamino lenalidomide-5-COOH is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-5-COOH can be linked to a target protein ligand via a linker to form a PROTAC.
Cat. No.: HY-W586328
CAS No.: 2866307-09-5
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Desamino lenalidomide-5-CO is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-5-CO can be linked to a target protein ligand via a linker to form a PROTAC.
Cat. No.: HY-W589407
CAS No.: 2412439-22-4
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Desamino lenalidomide-6-propyne is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-6-propyne can be linked to a target protein ligand via a linker to form a PROTAC.
Cat. No.: HY-W586343
CAS No.: 2642231-76-1
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Desamino lenalidomide-7-CO is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-7-CO can be linked to a target protein ligand via a linker to form a PROTAC.
Cat. No.: HY-W589406
CAS No.: 2412439-23-5
Target:
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Desamino lenalidomide-7-propyne is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-7-propyne can be linked to a target protein ligand via a linker to form a PROTAC.
Cat. No.: HY-W452755
CAS No.: 2243825-20-7
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(R)-Desamino lenalidomide-5-Br is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. (R)-Desamino lenalidomide-5-Br can be linked to a target protein ligand via a linker to form a PROTAC.
Cat. No.: HY-W586333
CAS No.: 2287262-43-3
Target:
Research Areas:
Desamino lenalidomide-5-C-COOH is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-5-C-COOH can be linked to a target protein ligand via a linker to form a PROTAC.
Cat. No.: HY-W586344
CAS No.: 2375260-16-3
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Desamino lenalidomide-4-C-COOH is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-4-C-COOH can be linked to a target protein ligand via a linker to form a PROTAC.
Research Areas:
Lenalidomide-C5-amido-Boc is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-amido-Boc can be connected to the ligand for protein by a linker to form PROTAC .
Cat. No.: HY-A0003BR
CAS No.: 847871-99-2
Synonyms: CC-5013 hemihydrate (Standard)
Research Areas:
Lenalidomide (hemihydrate) (Standard) is the analytical standard of Lenalidomide (hemihydrate). This product is intended for research and analytical applications. Lenalidomide hemihydrate (CC-5013 hemihydrate), a derivative of Thalidomide, acts as molecular glue. Lenalidomide hemihydrate is an orally active immunomodulator. Lenalidomide hemihydrate (CC-5013 hemihydrate) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide hemihydrate (CC-5013 hemihydrate) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells .
Cat. No.: HY-W586316
CAS No.: 2438240-74-3
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Desamino lenalidomide-6-Br-5-F is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-6-Br-5-F can be linked to a target protein ligand via a linker to form a PROTAC.
Cat. No.: HY-W586315
CAS No.: 2619512-24-0
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Desamino lenalidomide-4-Br-5-F is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-4-Br-5-F can be linked to a target protein ligand via a linker to form a PROTAC.
Cat. No.: HY-W868011
CAS No.: 2438238-19-6
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Desamino lenalidomide-4-Br-6-acetonitrile is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-4-Br-6-acetonitrile can be linked to a target protein ligand via a linker to form a PROTAC.
Cat. No.: HY-W074850
CAS No.: 1416990-26-5
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Desamino lenalidomide-ethynyl is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-ethynyl can be linked to a target protein ligand via a linker to form a PROTAC.
Cat. No.: HY-A0003A
CAS No.: 1243329-97-6
Synonyms: CC-5013 hydrochloride
Lenalidomide hydrochloride (CC-5013 hydrochloride) is an orally active immunomodulatory agent that binds CRBN as a molecular glue to alter substrate specificity, inducing ubiquitination and proteasome-dependent degradation of IKZF1, IKZF3 and CK1α. Lenalidomide hydrochloride induces apoptosis by degrading IKZF1/3, and activates p53 by degrading CK1α. Lenalidomide hydrochloride promotes IL-2 release and effector functions of CD8 + T/NK cells, while inhibiting TNF-α secretion and M1-type pyroptosis. Lenalidomide hydrochloride can be used in research related to hematological malignancies, acute liver failure and acute kidney injury .
Cat. No.: HY-161131
CAS No.: 2399455-71-9
Research Areas:
Lenalidomide 4'-alkyl-C3-azide (compound 4a) is a click chemical modified Lenalidomide (HY-A0003) that can be used to synthesize PROTACs. Lenalidomide is an orally active immunomodulator and a ligand for the ubiquitin E3 ligase cereblon (CRBN). Lenalidomide 4'-alkyl-C3-azide contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition reactions (SPAAC) can also occur with molecules containing DBCO or BCN groups .
Cat. No.: HY-156700
CAS No.: 2619512-84-2
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Lenalidomide-acetylene-Br is a PROTAC Linker taht makes up HJM-561 (HY-156698). HJM-561 is a potent, selective, and orally active EGFR PROTAC to inhiibit Osimertinib (HY-15772)-resistant EGFR triple mutations.
Cat. No.: HY-W1115204
CAS No.: 2520105-47-7
Research Areas:
Lenalidomide 5'-piperazine-C1-piperidine hydrochloride is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
