![Poly[bis(4-phenyl)(2,4,6-trimethylphenyl)amine]](https://file.medchemexpress.com/product_pic/hy-w391671.gif "Click to View Poly[bis(4-phenyl)(2,4,6-trimethylphenyl)amine] Product Detail")
Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
64 Results for "
optimal
" in MedChemExpress (MCE) Product Catalog:
Products (64)
64 Results for "optimal" in MCE Product Catalog:
Cat. No.: HY-P1115
CAS No.: 324029-01-8
Cat. No.: HY-P1115A
Cat. No.: HY-159484
CAS No.: 3056387-72-2
Target:
Research Areas:
Hsp110/sGC-modulator-1 (compound 17i), an orally active Hsp110/sGC dual-target regulator, exhibits optimal Hsp110 and sGC molecular activities as well as remarkable cell malignant phenotypes inhibitory and vasodilatory effects. Hsp110/sGC-modulator-1 (compound 17i) attenuates pulmonary vascular remodeling and right ventricular hypertrophy via Hsp110 suppression .
Cat. No.: HY-113858
CAS No.: 103880-26-8
Synonyms: Brefanolol
Target:
Research Areas:
Brefonalol (Brefanolol) is an orally active, non-selective β-adrenergic receptor blocker with vasodilatory properties. Brefonalol exhibits an optimal balance between β-blockade and vasodilatory effects at low doses: it reduces blood pressure and slows heart rate, while increasing stroke volume instead of decreasing it, causing no significant elevation in peripheral resistance and increasing reactive hyperemia; at high doses, the β-blockade effect dominates. Brefonalol can be used in the research of arterial hypertension .
Cat. No.: HY-W800698
CAS No.: 2006309-79-9
Cat. No.: HY-W800775
CAS No.: 2770422-56-3
Cat. No.: HY-W800692
CAS No.: 2644752-84-9
Cat. No.: HY-121856
CAS No.: 36740-73-5
Target:
Research Areas:
Flumizole, a derivative of substituted 5,6-diaryl-2,3-dihydroimidazo[2,1-b]thiazoles, was synthesized and evaluated for its immunoregulatory and anti-inflammatory properties in animal models such as rat adjuvant-induced arthritis and mouse oxazolone-induced contact sensitivity assays. This compound class combines structural elements from flumizole and levamisole, aiming to enhance therapeutic efficacy. Symmetrically substituted 5,6-diaryl compounds with specific alkyl heteroatom or halogen substitutions showed optimal potency in the arthritis model. However, variations in activity were less consistent in the contact sensitivity assay. Flumizole and related compounds demonstrate potential as dual-action agents, targeting inflammation and immune modulation, offering promise for therapeutic development in immune-related disorders .
Cat. No.: HY-W391671
CAS No.: 1333317-99-9
Research Areas:
Poly[bis(4-phenyl)(2,4,6-trimethylphenyl)amine] is a poly(triarylamine) that is an organic p-type semiconductor with hole mobilities ranging from 10 3 to 10 2 cm 2/V/s, which significantly improves carrier mobility. This stable, glassy polymer has an ionization potential suitable for thick film diodes. Committed to providing green alternatives that meet one or more of the 12 principles of green chemistry, this material falls into the enabling category of green alternatives, in line with the principle of "energy efficient design". In addition, while hole transport organic materials like these ensure optimal energy level alignment with the absorber layer for efficient charge collection, they can be susceptible to degradation under ambient conditions.
Cat. No.: HY-15334
CAS No.: 402857-39-0
CEP-5214, derived from a new indenopyrrolocarbazole template, is a potent inhibitor of vascular endothelial growth factor R2 (VEGF-R2) tyrosine kinase. Structurally, it features optimal substitutions at positions 9 (ethoxymethyl) and 12 (hydroxypropyl) on the indeno[2,1-a]pyrrolo[3,4-c]carbazole-5-one scaffold, leading to high potency against VEGF-R2 (IC50 8 nM). Compound 21 (CEP-5214) exhibits low-nanomolar inhibition of human VEGF-R tyrosine kinases (IC50 4 nM for VEGF-R2/KDR), with good selectivity over other kinases. The compound demonstrated significant cellular and in vivo antitumor activity across various models and advanced into phase I clinical trials as a water-soluble prodrug (CEP-7055) to enhance oral bioavailability .
Cat. No.: HY-E71539
Target:
Research Areas:
2-Hexadecenal reductase (EC 1.3.1.27): specific for long chain 2-trans- and 2-cis-alkenals, with chain length optimum around 14 to 16 carbon atoms.
Cat. No.: HY-L0087V
503,810 compounds
Life Chemicals Collection of small organic molecules for high-throughput screening currently contains 503,810 off-the-shelf products. The Collection is being permanently replenished with de novo designed products having optimal physicochemical parameters for drug discovery.
Cat. No.: HY-P2778A
Target:
Research Areas:
Thermally stable RNase H degrades the RNA strand of a DNA-RNA hybrid without affecting the DNA or unhybridized RNA strands, significantly improving sensitivity and selectivity. Thermally stable RNase H has optimal activity at 65°C and remains active at 95°C.
Cat. No.: HY-E71164
Target:
Research Areas:
1,5-Anhydro-D-fructose dehydratase (EC 4.2.1.111) catalyses one of the steps in the anhydrofructose pathway, which leads to the degradation of glycogen and starch via 1,5-Anhydro-D-fructose . Requires divalent (Ca2+ or Mg2+) or monovalent cations (Na+) for optimal activity.
Cat. No.: HY-E70932
Target:
Research Areas:
Non-Prostatic Acid Phosphatase, Sweet Potato (EC 3.1.3.2), a type of enzyme, used to free attached phosphoryl groups from other molecules during digestion. Acid phosphatase is stored in lysosomes and functions when these fuse with endosomes, which are acidified while they function; therefore, it has an acid pH optimum. This enzyme is present in many animal and plant species.
Cat. No.: HY-P2863A
Target:
Research Areas:
Deoxyribonuclease II, Bovine (EC 3.1.22.1) hydrolyzes deoxyribonucleotide linkages in native and denatured DNA yielding products with 3'-phosphates. In vitro, its optimum pH range is 4.5-5.0. Deoxyribonuclease II, Bovine (EC 3.1.22.1) also acts upon p-nitrophenyl-phosphodiesters at pH 5.6-5.9.
Cat. No.: HY-K2032
MCE Polybrene (10 mg/mL) is provided as a ready-to-use solution, prepared in 0.9% saline and sterilized by filtration through a 0.22 μm membrane. For use, it is typically diluted 1:1000-1:2000 to the working concentration. The optimal working concentration may vary depending on cell type and experimental conditions and should be empirically optimized based on relevant literature or preliminary experiments.
Cat. No.: HY-113858A
CAS No.: 3026677-28-8
Synonyms: Brefanolol hydrochloride
Target:
Research Areas:
Brefonalol (Brefanolol) hydrochloride is an orally active, non-selective β-adrenergic receptor blocker with vasodilatory properties. Brefonalol hydrochloride exhibits an optimal balance between β-blockade and vasodilatory effects at low doses: it reduces blood pressure and slows heart rate, while increasing stroke volume instead of decreasing it, causing no significant elevation in peripheral resistance and increasing reactive hyperemia; at high doses, the β-blockade effect dominates. Brefonalol hydrochloride can be used in the research of arterial hypertension .
Cat. No.: HY-L0088V
50,240 compounds
Life Chemicals presents a number of exclusive Pre-Plated Diversity Sets composed of 50,240 novel compounds with optimal physicochemical properties selected from Life Chemicals collection of newly synthesized items by dissimilarity search with an average Tanimoto threshold of 82%. These Diverse Screening Sets are ideal starting points for customers looking for a wide range of dissimilarity to screen against a number of targets from different classes or where little information is available on targeted protein structure.
Cat. No.: HY-W747104
CAS No.: 52957-16-1
Category:
Target:
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
