254 Results for "

Mer,

" in MedChemExpress (MCE) Product Catalog:
Products (254)

254 Results for "Mer," in MCE Product Catalog:

Cat. No.: HY-160230
Research Areas:  

Infection

ssRNA41 sodium is a 20-mer phosphothioate protected single-stranded RNA oligonucleotide. It derives from ssRNA40 by replacement of all U nucleotides with adenosine. ssRNA41 sodium is unable to induce the production of type IFNs, and therefore can be used as a negative control for ssRNA40 .
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Cat. No.: HY-149906C
Purity:  98.83%
Synonyms: GEM91 sodium
Target:  

HIV

Research Areas:  

Infection

Trecovirsen sodium is a 25-mer antisense phosphorothioate oligonucleotide targeted at the gag site of the HIV gene.
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Cat. No.: HY-P991551
CAS No.: 1656248-21-3

Research Areas:  

Infection Cancer

YS110 is a humanized anti-CD26 (DPP4) IgG1 monoclonal antibody. YS110 induces CD26 nuclear translocation through the caveolin pathway. YS110 inhibits the proliferation of tumor cell by delaying G2/M cell cycle transition. YS110 inhibits the infection of Middle East respiratory syndrome coronavirus (MERS CoV) by blocking the binding of MERS CoV S1 to CD26. YS110 can be used for researches on cancer or infection such as Malignant Mesothelioma and MERS .
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Cat. No.: HY-153840A
Purity:  97.03%
Research Areas:  

Inflammation/Immunology

ODN INH-18 sodium is a linear 24-mer class B INH-ODN in which the 5' INH-ODN 4084-F sequence was followed by a random stretch of 12 nucleotides lacking the ability to form significant secondary structures. ODN INH-18 sodium showes inhibitory potency for TLR9 ligand-induced IFN-α production.
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Cat. No.: HY-160231
Research Areas:  

Inflammation/Immunology

ssRNA42 (sodium) is a 20-mer phosphothioate protected single-stranded RNA oligonucleotide. ssRNA42 (sodium) derives from ssRNA40 by replacement of all G nucleotides with adenosine. ssRNA42 activated human PBMCs to secrete IFN-α, TNF-a, IL- 12p40, and IL-6, but ssRNA42 failed to stimulated murine pDCs and PBMCs.
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Cat. No.: HY-162946
Research Areas:  

Cancer

Alkyne-P60 is a potent 15-mer peptide inhibitor of Foxp3. Alkyne-P60 can bind with Foxp3, hinder its nuclear translocation, and diminish Foxp3-mediated inhibition of NFKB and NFAT functions. Alkyne-P60 is a ligand for target protein for PROTAC (HY-162943).
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Cat. No.: HY-P2468
CAS No.: 331762-68-6
Synonyms: BADBH3 103-127 (human); BADBH3 (human)
Target:  

Bcl-2 Family

Research Areas:  

Cancer

BAD (103-127) (human), the 25-mer Bad peptide, is derived from the BH3 domain of BAD, can antagonize the function of Bcl-xL. BAD (103-127) (human) is reported to have almost 800-fold higher affinity for Bcl-XL than the 16-mer peptide .
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Cat. No.: HY-114426
CAS No.: 835872-35-0
Target:  

Gap Junction Protein

Research Areas:  

Metabolic Disease

AT-1002, a 6-mer synthetic peptide , is a tight junction regulator and absorption enhancer .
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IMT504 sodium
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DNA, d(P-thio)(T-C-A-T-C-A-T-T-T-T-G-T-C-A-T-T-T-T-G-T-C-A-T-T), sodium salt
Cat. No.: HY-158822A
Purity:  99.35%
IMT504 sodium, a non-CpG 24-mer oligodeoxynucleotide, is an immunomodulatory oligonucleotide currently being investigated as a rabies vaccine. IMT504 sodium has been previously proven to be effective in animal models of vaccine potency, chronic lymphocytic leukemia, tissue regeneration, and sepsis.
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Cat. No.: HY-162645
CAS No.: 3029897-97-7
Target:  

TAM Receptor

Research Areas:  

Inflammation/Immunology Cancer

BPR5K230 is a dual inhibitor for the receptor tyrosine kinase MER and AXL, with IC50 of 4.1 nM and 9.2 nM. BPR5K230 inhibits the proliferation of Ba/F3-MER with IC50 of 5 nM. BPR5K230 exhibits good pharmacokinetic characteristics in mice, exhibits anti-inflammatory and antitumor against 4T1, MDA-MB-231, MC38 and Hepa1?6 in mouse models .
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Cat. No.: HY-P2499A
Target:  

Bcl-2 Family

Research Areas:  

Cancer

BAD (103-127) (human), FAM-labeled TFA is a FAM-labeled human BAD (103-127) (HY-P2468). BAD (103-127) (human) TFA, the 25-mer Bad peptide, is derived from the BH3 domain of BAD and can antagonize the function of Bcl-xL .
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Cat. No.: HY-15519
CAS No.: 867324-12-7
Target:  

IAP FLT3

Research Areas:  

Cancer

LBW242, a 3-mer and Smac mimetic, is a potent and orally active proapoptotic IAP inhibitor. LBW242 shows effects on mutant FLT3-expressing cells. LBW242 has activity against multiple myeloma, and potentiates TRAIL- and anticancer agent-mediated cell death of ovarian cancer cells .
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Cat. No.: HY-153012
CAS No.: 2394874-60-1
Target:  

TAM Receptor c-Fms

Research Areas:  

Cancer

Axl/Mer-IN-1 (Compound 1) is an Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R inhibitor with Kds of <0.1 μM .
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Tetracycline aptamer sodium
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RNA, 5'-GGGCUAAAACAUACCAGAUUUCGAUCUGGAGAGGUGAAGAAUACGACCACCUAGCUC-3', sodium salt
Cat. No.: HY-177805
Tetracycline aptamer sodium is a 57mer-RNA aptamer that targets tetracycline.
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Cat. No.: HY-153834
CAS No.: 236391-66-5
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

GTI-2040, a 20-mer phosphorothioate oligonucleotide, was designed to hybridize to the mRNA sequence of human ribonucleotide reductase R2. GTI-2040 has been shown to inhibit human cancer cell proliferation by downregulation of R2 expression in vitro and to significantly inhibit tumor growth in xenograft models of human cancer in mice.
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Cat. No.: HY-P10935
CAS No.: 1860001-61-1
Synonyms: 5-MP
Research Areas:  

Inflammation/Immunology

Amilo-5MER (5-MP) is an orally active and selective Serum Amyloid A (SAA) inhibitor. Amilo-5MER specifically inhibits the release of pro-inflammatory cytokines IL-6 and IL-1β from SAA-activated cells. Amilo-5MER reduces chronic inflammation and relieves symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). Amilo-5MER is promising for research of autoimmune diseases and chronic inflammatory diseases .
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Cat. No.: HY-N16422
CAS No.: 159121-98-9
Mer-NF5003E is a non-nucleoside reverse transcriptase inhibitor targeting HIV-1 reverse transcriptase (RT) (EC50=50 μM). Mer-NF5003E exhibits inhibitory activity against wild-type HIV-1 and multiple NNRTI-resistant strains (e.g., K103N, Y181C). Mer-NF5003E is promising for research of HIV infections .
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Cat. No.: HY-P3129
CAS No.: 145019-94-9
Target:  

Ras

Research Areas:  

Inflammation/Immunology Cancer

KRAS G13D peptide, 25 mer, a KRAS activating oncogene mutation peptide, is an immune potentiator extracted from patent WO2018144775A1. KRAS G13D peptide, 25 mer can be used to prepare KRAS vaccine .
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Cat. No.: HY-P9806
Synonyms: MERS-D12; MERS Antibody-D12

Target:  

SARS-CoV

Research Areas:  

Infection

Anti-MERS-D12 mAb (MERS-D12; MERS Antibody-D12) is a human monoclonal IgG1. Anti-MERS-D12 mAb binds directly to the DPP4 interacting region of the MERS-CoV Spike receptor binding domain (RBD) and effect neutralization by directly blocking receptor binding .
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Cat. No.: HY-153488
CAS No.: 149957-14-2
Target:  

Ras

Research Areas:  

Cancer

ISIS-2503 is a 20-mer antisense oligonucleotide that inhibits Ha-Ras expression
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