GTI 2040
GTI-2040, a 20-mer phosphorothioate oligonucleotide, was designed to hybridize to the mRNA sequence of human ribonucleotide reductase R2. GTI-2040 has been shown to inhibit human cancer cell proliferation by downregulation of R2 expression in vitro and to significantly inhibit tumor growth in xenograft models of human cancer in mice.
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- CAS No.: 236391-66-5
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Chemical Information
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CAS No. 236391-66-5
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SMILES
[GTI 2040]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Vassilakos A, Lee Y, Viau S, et al. GTI-2040 displays cooperative anti-tumor activity when combined with interferon alpha against human renal carcinoma xenografts. Int J Oncol. 2009;34(1):33-42. [Content Brief]
[2]. Ferdinandi ES, Vassilakos A, Lee Y, et al. Preclinical toxicity and toxicokinetics of GTI-2040, a phosphorothioate oligonucleotide targeting ribonucleotide reductase R2. Cancer Chemother Pharmacol. 2011;68(1):193-205. doi:10.1007/s00280-010-1473-z [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GTI 2040 Related Classifications
HY-153834 Related Classifications
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