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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
94 Results for "
HSC
" in MedChemExpress (MCE) Product Catalog:
Products (94)
94 Results for "HSC" in MCE Product Catalog:
Cat. No.: HY-N3523
CAS No.: 38337-25-6
Category:
Triterpenes Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Disease Research Fields Cancer
Target:
Cat. No.: HY-172275B
Target:
Research Areas:
DSPE-PEG5000-pPB is a PEG compound which composed of DSPE and a cyclic oligopeptide (pPB). pPB has a strong binding affinity with PDGFRβ, which is overexpressed on activated hepatic stellate cells (HSC). DSPE-PEG5000-pPB can be used for drug delivery .
Cat. No.: HY-10341D
CAS No.: 1001206-62-7
Synonyms: HA-1077 mesylate; AT-877 mesylate
Fasudil (HA-1077; AT877) mesylate is a nonspecific and orally active RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil mesylate is also a potent Ca 2+ channel antagonist and vasodilator .
Cat. No.: HY-170543
Research Areas:
Dual Galectin-3/EGFR-IN-1 (Compound 29) is the dual inhibitor for Galectin-3 and EGFR with the KD of 52.29 μM and 3.31 μM. Dual Galectin-3/EGFR-IN-1 inhibits TGF-β-induced hepatic stellate cell (HSCs) activation, induces apoptosis in LX-2 cell, and exhibits anti-liver fibrotic efficacy .
Cat. No.: HY-184691
CAS No.: 3109806-14-3
Target:
Research Areas:
HSC-4 is an orally active anti-inflammatory agent and a derivative of Hederacoside C (HY-N0253). HSC-4 inhibits the secretion of IL-6. HSC-4 exerts protective effects in mouse models of systemic sepsis and acute lung injury. HSC-4 can be used for the research of acute lung injury and systemic sepsis .
Cat. No.: HY-10341B
CAS No.: 186694-02-0
Synonyms: HA-1077 hydrochloride semihydrate; AT877 hydrochloride semihydrate
Fasudil (HA-1077; AT877) hydrochloride semihydrate is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil hydrochloride semihydrate is also a potent Ca 2+ channel antagonist and vasodilator .
Cat. No.: HY-122179
CAS No.: 1060469-90-0
Target:
Research Areas:
NUCC-555 is an activin antagonist. NUCC-555 interacts with Trp25, Trp28, Phe55, Tyr93, Lys103, and Asn107 in the Activin A binding pocket. NUCC-555 blocks Activin A-mediated hepatic stellate cells (HSCs) activation. NUCC-555 promotes liver regeneration and halts fibrosis progression in chronic liver disease models. NUCC-555 inhibits Activin A-mediated ovarian cell proliferation. NUCC-555 decreases FSH levels in ovariectomized mice .
Cat. No.: HY-182501
CAS No.: 1015855-72-7
Target:
Research Areas:
HSC mobilizer-1 (Compound 3) is an in vitro expansion activator of HSC. HSC mobilizer-1 promotes the in vitro expansion of hematopoietic stem cells .
Cat. No.: HY-117947
CAS No.: 1809336-19-3
Target:
Research Areas:
(R)-OR-S1 is an isomer of OR-S1. The dual ZH1/2 inhibitors OR-S1 and OR-S2 exhibit strong inhibitory activity against both EZH1 and EZH2. OR-S1 and OR-S2 are highly selective methyltransferase inhibitors against EZH1 and EZH2, and they have very similar molecular features. Therefore, we investigated the effect of OR-S1 on acute myeloid leukemia (AML). We found that OR-S1 was able to induce cell differentiation and apoptosis in AML cells. These findings encouraged us to investigate whether functional LT-HSCs could survive PRC2-targeted therapy with OR-S1 or OR-S1 combined with cytarabine. The results showed that OR-S1 did not cause significant myelosuppression, and BM cells treated with the combination therapy were able to undergo normal hematopoiesis even 4 months after treatment. Therefore, temporary inhibition of EZH1 and EZH2 is clinically tolerable, making this combination therapy suitable for AML patients. AML is generally believed to originate from myeloid progenitor cells that inherit a large number of biological properties.
Cat. No.: HY-P86734
Synonyms: 2410008N15Rik; Constitutive heat shock protein 70; Heat shock 70 kDa protein 8; Heat shock 70kD protein 10; Heat shock 70kD protein 8; Heat shock 70kDa protein 8; Heat shock cognate 71 kDa protein; Heat shock cognate protein 54; Heat shock cognate protein 71 kDa; Heat shock protein 8; Heat shock protein A8; Heat-shock70-KD protein 10, formerly; HSC54; HSC71; HSC73; HSP71; HSP73; HSP7C_HUMAN; HSPA10; HSPA8; LAP1; Lipopolysaccharide associated protein 1; LPS associated protein 1; LPS associated protein; MGC102007; MGC106514; MGC114311; MGC118485; MGC131511; MGC29929; N-myristoyltransferase inhibitor protein 71; NIP71; HSC 70; HSC-70.
Cat. No.: HY-P86734A
Synonyms: 2410008N15Rik; Constitutive heat shock protein 70; Heat shock 70 kDa protein 8; Heat shock 70kD protein 10; Heat shock 70kD protein 8; Heat shock 70kDa protein 8; Heat shock cognate 71 kDa protein; Heat shock cognate protein 54; Heat shock cognate protein 71 kDa; Heat shock protein 8; Heat shock protein A8; Heat-shock70-KD protein 10, formerly; HSC54; HSC71; HSC73; HSP71; HSP73; HSP7C_HUMAN; HSPA10; HSPA8; LAP1; Lipopolysaccharide associated protein 1; LPS associated protein 1; LPS associated protein; MGC102007; MGC106514; MGC114311; MGC118485; MGC131511; MGC29929; N-myristoyltransferase inhibitor protein 71; NIP71; HSC 70; HSC-70.
Cat. No.: HY-P705926
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: HSPA8; Epididymis Secretory Sperm Binding Protein Li 72p; Prev. HSPA10; Constitutive Heat Shock Protein 70; HSC70; Epididymis Luminal Protein 33; HSP73; Heat Shock Cognate Protein 54; Heat Shock Cognate 71 KDa Protein; Heat Shock 70kd Protein 10; HSC71; H
Species:
Human
Source:
P. pastoris
Cat. No.: HY-P703390
Synonyms: HSCB; HSCB Mitochondrial Iron-Sulfur Cluster Co-Chaperone; HSCB Mitochondrial Iron-Sulfur Cluster Cochaperone; HSCB Iron-Sulfur Cluster Co-Chaperone Homolog; DNAJC20; Epididymis Secretory Sperm Binding Protein; HSC20; J-Type Co-Chaperone HSC20, Isoform CR
Species:
Human
Source:
E. coli
Cat. No.: HY-100791R
CAS No.: 1796596-46-7
Target:
Research Areas:
NSC23005 (sodium) (Standard) is the analytical standard of NSC23005 (sodium) (HY-100791). This product is intended for research and analytical applications. NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.
Cat. No.: HY-172275
Target:
Research Areas:
DSPE-PEG1000-pPB is a PEG compound which composed of DSPE and a cyclic oligopeptide (pPB). pPB has a strong binding affinity with PDGFRβ, which is overexpressed on activated hepatic stellate cells (HSC). DSPE-PEG1000-pPB can be used for drug delivery .
Cat. No.: HY-172275C
Target:
Research Areas:
DSPE-PEG3400-pPB is a PEG compound which composed of DSPE and a cyclic oligopeptide (pPB). pPB has a strong binding affinity with PDGFRβ, which is overexpressed on activated hepatic stellate cells (HSC). DSPE-PEG3400-pPB can be used for drug delivery .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
