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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
120 Results for "
RNA-binding
" in MedChemExpress (MCE) Product Catalog:
Products (120)
120 Results for "RNA-binding" in MCE Product Catalog:
Cat. No.: HY-L248
858 compounds
The RNA-targeted bioactive compound library is a high-quality collection of small molecules specifically designed and curated to target RNA structures and functions. It is widely applied in cutting-edge drug discovery and life science research. Unlike traditional strategies that focus on protein targets, RNA-targeted compounds can directly modulate various functional RNA molecules by influencing their splicing, translation, stability, or structural conformation, thereby enabling precise intervention in key biological processes. In the field of drug development, these compounds provide a novel approach to addressing previously “undruggable” targets and have demonstrated significant potential in areas such as oncology, antiviral therapies, and neurodegenerative diseases. For example, by targeting disease-associated RNA structural domains or regulating the aberrant expression of non-coding RNAs, these compounds can effectively inhibit disease progression or restore normal cellular function. In mechanistic studies, RNA-targeted compounds serve as valuable chemical biology tools to elucidate the roles of RNA in gene expression regulation, cellular signaling pathways, and disease development.
The MCE RNA-targeted bioactive compound library contains 858 compounds, sourced from databases such as TargetRX Atlas and R-BIND. The library features excellent structural diversity and biological activity, making it suitable for high-throughput screening (HTS), target validation, phenotypic screening, and lead compound discovery. It represents a valuable resource for RNA-related research and innovative drug development.
Cat. No.: HY-P703543
Synonyms: Replicase polyprotein 1ab; ORF1ab polyprotein; rep; Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; pp1ab; Endonuclease; Exonuclease; Helicase; Hydrolase; Lyase; Methyltransferase; Nuclease Nucleotidyltransferase; Protease; RNA-binding; RNA-directed RNA polymerase; Thiol protease; Transferase;
Species:
Virus
Source:
Sf9 insect cells
Cat. No.: HY-P83061
Synonyms: CELF1; BRUNOL2; CUGBP; CUGBP1; NAB50; CUGBP Elav-like family member 1; CELF-1; 50 kDa nuclear polyadenylated RNA-binding protein; Bruno-like protein 2; CUG triplet repeat RNA-binding protein 1; CUG-BP1; CUG-BP- and ETR-3-like factor 1; Dead
Cat. No.: HY-P700506
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: EIF3G; EIF-3 RNA-binding Subunit; Prev. EIF3S4; EIF3 P44; Eukaryotic Translation Initiation Factor 3 RNA-binding Subunit; EIF3 P42; EIF3-Delta; EIF3g; EIF3-P44; Eukaryotic Translation Initiation Factor 3 Subunit P42; Eukaryotic Translation Initiation Fact
Species:
Human
Source:
E. coli
Cat. No.: HY-108466R
CAS No.: 37854-59-4
Target:
Research Areas:
Ro 08-2750 (Standard) is the analytical standard of Ro 08-2750 (HY-108466). This product is intended for research and analytical applications. Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~ 1 μM. Ro 08-2750 inhibits NGF binding to p75NTR selectively over TRKA . Ro 08-2750 is a selective MSI RNA-binding activity inhibitor, with an IC50 of 2.7 μM .
Cat. No.: HY-P705436
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TIA1; TIA1 Cytotoxic Granule-Associated RNA-binding Protein; TIA1 Cytotoxic Granule Associated RNA binding Protein; P40-TIA-1 (Containing P15-TIA-1); T-Cell-Restricted Intracellular Antigen-1; AlteRNAtive Protein TIA1; TIA-1; P40-TIA-1; Cytotoxic Granule
Species:
Human
Source:
E. coli
Cat. No.: HY-P71612
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RBM14; SYT-Interacting Protein; RNA binding Motif Protein 14; Paraspeckle Protein 2; SIP; DKFZp779J0927; RNA-binding Protein 14; PSP2; SYTIP1; Transmembrane Protein 137; COAA; SYT Interacting Protein; RRM-Containing Coactivator Activator/Modulator; Coacti
Species:
Human
Source:
E. coli
Cat. No.: HY-P82093
Synonyms: SYNCRIP; HNRPQ; NSAP1; Heterogeneous nuclear ribonucleoprotein Q; hnRNP Q; Glycine- and tyrosine-rich RNA-binding protein; GRY-RBP; NS1-associated protein 1; Synaptotagmin-binding; cytoplasmic RNA-interacting protein
Cat. No.: HY-P87370
Synonyms: 44kDa antibody; Anti EIF3S4 antibody; eIF 3 delta antibody; eIF 3 RNA binding subunit antibody; eIF-3 RNA-binding subunit antibody; eIF-3-delta antibody; eIF3 delta antibody; eIF3 p42 antibody; eIF3 p44 antibody; eIF3g antibody
Cat. No.: HY-187350
Research Areas:
LRPPRC-IN-1 is a LRPPRC inhibitor. LRPPRC-IN-1 exerts dual effects of inhibiting LRPPRC activity and inducing its degradation by binding to the RNA-binding domain of LRPPRC. LRPPRC-IN-1 downregulates the expression of mitochondrial OXPHOS complex subunits and ATP synthase, inhibits oxidative phosphorylation, reduces ATP production, suppresses the proliferation and colony formation of various cancer cells, and inhibits tumor growth in vivo. LRPPRC-IN-1 can be used in studies related to lung cancer, pancreatic cancer, breast cancer, esophageal cancer, colorectal cancer, lymphoma, melanoma, cervical cancer, ovarian cancer, and prostate cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
