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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
147 Results for "
interface
" in MedChemExpress (MCE) Product Catalog:
Products (147)
147 Results for "interface" in MCE Product Catalog:
Cat. No.: HY-W284558S
CAS No.: 2708287-31-2
Cat. No.: HY-136258
CAS No.: 2250025-94-4
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nAChR agonist CMPI hydrochloride is a potent and selective positive allosteric modulator (PAM) of nAChR containing a α4:α4 subunit interface. nAChR agonist CMPI hydrochloride enhances the response of (α4)3(β2)2 nAChR to ACh (10 µM) with an EC50 of 0.26 µM. nAChR agonist CMPI hydrochloride has potential for the research of nicotine dependence and many neuropsychiatric conditions associated with decreased brain cholinergic activity .
Cat. No.: HY-147255A
CAS No.: 2137847-77-7
Synonyms: (S)-ZM-H1505R
(S)-Canocapavir is the isomer of Canocapavir (HY-147255A). Canocapavir (ZM-H1505R) is an orally active HBV core protein-targeting antiviral agent. Canocapavir binds to the hydrophobic pocket at the dimer-dimer interface of HBV core protein (HBc), stimulating intracellular accumulation of nonfunctional HBV capsids, disrupting viral replication. Canocapavir interferes with the interaction between HBc and HBV large surface protein, resulting in diminished
production of empty virionsis. Canocapavir can be used for the research of hepatitis B virus (HBV) infection .
production of empty virionsis. Canocapavir can be used for the research of hepatitis B virus (HBV) infection .
Cat. No.: HY-175178
CAS No.: 1214645-87-0
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Arrestin-3 modulator-1 (Compound LSH-3) is an arrestin-3 modulator. Arrestin-3 modulator-1 binds arrestin-3 at the interdomain interface. Arrestin-3 modulator-1 enhances recruitment of arrestin-3 to phosphorylation-deficient β2AR in cells with increase of FRET levels. Arrestin-3 modulator-1 can be used for congenital disorders like retinal degeneration, hyperthyroidism and obesity research .
Cat. No.: HY-161824
CAS No.: 2913194-20-2
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Antiproliferative agent-52 is a tubulin inhibitor with a porcine tubulin KD of 29.65 μM. Antiproliferative agent-52 binds to the colchicine-binding site at the α-tubulin and β-tubulin interface and inhibits tubulin polymerization. Antiproliferative agent-52 exhibits antiproliferative activity against tumor cells. Antiproliferative agent-52 serves as a lead compound for development of thienopyrimidine and heterocyclic fused pyrimidines with antiproliferative activity. Antiproliferative agent-52 can be used for the research of ovarian cancer, non-small cell lung cancer .
Cat. No.: HY-183293
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Cbl-b-IN-32 is a Cbl-b inhibitor with an IC50 of 6.83 μM. Cbl-b-IN-32 binds to the TKB-LH interface, stabilizes the inactive conformation of Cbl-b, engages Tyr363 via hydrogen bonds and water bridges, and forms hydrogen bonds with Phe261 and Phe263 .
Cat. No.: HY-P11770
CAS No.: 1352117-55-5
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Cat. No.: HY-179706
CAS No.: 2576427-49-9
VS3 is a YAP-TEAD interaction inhibitor. VS3 directly disrupts the interaction between YAP-TEAD by binding to TEAD4 Interface 3 (Kd = 6 μM) on the surface. VS3 exhibits anti-proliferative activity against HT29, HCT116, and A2780. VS3 can be used for research on colorectal adenocarcinoma and ovarian cancer .
Cat. No.: HY-182280
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BDM71230 is an orally active inducer of insulin-degrading enzyme (IDE), with an EC50 of 1.9 μM against human IDE. BDM71230 binds to the interface of IDE dimers and enhances the catalytic activity of IDE via steric effects. BDM71230 can potentiate the hydrolytic effect of IDE on insulin and slightly attenuate the hypoglycemic effect of insulin. BDM71230 serves as a pharmacological tool for investigating IDE function and is applicable to studies related to glucose intolerance .
Cat. No.: HY-181066
Research Areas:
ACE2-SP PPI-IN-1 is an inhibitor of the interaction between the SARS-CoV-2 spike protein and ACE2, with an IC50 of 2162.77 nM. ACE2-SP PPI-IN-1 exhibits low cytotoxicity in human fibroblasts. ACE2-SP PPI-IN-1 binds to the interface region between the spike protein RBD and ACE2, reducing the flexibility of the critical receptor-binding loop and maintaining the structural compactness of the spike protein. ACE2-SP PPI-IN-1 can be used for research related to SARS-CoV-2 .
Cat. No.: HY-131694
CAS No.: 69313-68-4
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N-Dodecyllactobionamide is a sugar surfactant that can be used to the study of the effect of the structure of the sugar headgroup on the adsorption to liquid/vapor and solid/liquid interfaces .
Cat. No.: HY-179850
CAS No.: 1219008-49-7
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Mal(11.1) is a new type of detergent that contains a short branched alkyl chain at the interface between the polar head and the non-polar tail.
Cat. No.: HY-179851
CAS No.: 1219008-64-6
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Mal(11.2) is a new type of detergent that contains a short branched alkyl chain at the interface between the polar head and the non-polar tail.
Cat. No.: HY-179852
CAS No.: 1219008-68-0
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Mal(12.1) is a new type of detergent that contains a short branched alkyl chain at the interface between the polar head and the non-polar tail.
Cat. No.: HY-P11842
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Cat. No.: HY-182047
CAS No.: 2983098-90-2
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PD-1/PD-L1-IN-61 is a PD-1/PD-L1 interaction inhibitor with a human IC50 of 5.3 nM. PD-1/PD-L1-IN-61 embeds into the hydrophobic pocket at the PD-L1 dimer interface, stabilizing binding through hydrogen bonds and π-π stacking with PD-L1 residues. PD-1/PD-L1-IN-61 acts as an immune activator, enhances immune-killing activity of peripheral blood mononuclear cells against cancer cells, restores T-cell immune function, and promotes IFN-γ secretion. PD-1/PD-L1-IN-61 can be used for the research of triple-negative breast cancer .
Cat. No.: HY-107205
CAS No.: 13861-22-8
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Propargyl methacrylate is an effective electrolyte additive used to stabilize the formation of the solid electrolyte interface (SEI) layer on meso-porous carbon microbeads (MCMB) in lithium-ion batteries .
Cat. No.: HY-117939
CAS No.: 171347-75-4
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GM1489 is an MMP inhibitor that reduces degradation at the resin-dentin interface by inhibiting MMP activity, thereby enhancing bonding stability. GM1489 shows potential for researching strategies to improve bonding stability in both superficial and deep dentin .
Cat. No.: HY-101093R
CAS No.: 1673534-76-3
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CA-170 (Standard) is the analytical standard of CA-170 (HY-101093). This product is intended for research and analytical applications. CA-170 is an orally delivered dual inhibitor of VISTA and PD-L1. CA-170 exhibits potent rescue of proliferation and effector functions of T cells inhibited by PD-L1/L2 and VISTA with selectivity over other immune checkpoint proteins as well as a broad panel of receptors and enzymes .
Cat. No.: HY-181157
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T/E PPI-IN-1 (Compound C87) is a TRIM28-EZH2 interaction inhibitor targeting reactive cysteines at the interface. T/E PPI-IN-1 can be used for the research of cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
