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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
117 Results for "
Pyruvate Kinase
" in MedChemExpress (MCE) Product Catalog:
Products (117)
117 Results for "Pyruvate Kinase" in MCE Product Catalog:
Cat. No.: HY-P703578
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: PDK3; Pyruvate Dehydrogenase, Lipoamide, Kinase Isozyme 3, Mitochondrial; Pyruvate Dehydrogenase Kinase 3; Pyruvate Dehydrogenase Kinase Isoform 3; [Pyruvate Dehydrogenase (Acetyl-Transferring)] Kinase Isozyme 3, Mitochondrial; GS1-358P8.4; Pyruvate Dehyd
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P705854
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PDK2; PDH Kinase 2; Pyruvate Dehydrogenase Kinase 2; PDKII; PDHK2; Pyruvate Dehydrogenase, Lipoamide, Kinase Isozyme 2, Mitochondrial; [Pyruvate Dehydrogenase (Acetyl-Transferring)] Kinase Isozyme 2, Mitochondrial; Pyruvate Dehydrogenase Kinase Isoform 2
Species:
Human
Source:
sf9 insect cells
Cat. No.: HY-L058
1,379 compounds
Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation.
Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications.
MCE provides a unique collection of 1,379 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.
Cat. No.: HY-L092
1,777 compounds
Glucose homeostasis is tightly regulated to meet the energy requirements of the vital organs and maintain an individual’s health. Glucose metabolism includes glycolysis, tricarboxylic acid cycle, pentose phosphate pathway, oxidative phosphorylation and other metabolic pathways. Glucose is the major carbon source that provides the main energy for life. Glucose metabolism dysregulation is also implicated in many diseases such as diabetes, heart disease, neurodegenerative diseases and even cancer.
MCE offers a unique collection of 1,777 compounds related to glucose metabolism, which target glucose metabolism related targets, such as GLUT, Hexokinase, Pyruvate Kinase, IDH, etc. MCE glucose metabolism library is a powerful tool for studying glucose metabolism and drug discovery of diseases related to glucose metabolism.
Cat. No.: HY-182037
Target:
Research Areas:
Multi-target kinase-IN-9 is a multi-target enzyme inhibitor with antiproliferative and antiangiogenic activities, and exhibits remarkable selectivity against hepatocellular carcinoma cells. By broadly binding to the active sites or ATP-binding regions of multiple key enzymes including DNA polymerase β, Pyruvate Kinase M2 (PKM2), Multi-target kinase-IN-9 comprehensively disrupts DNA repair and replication, glycolysis, chromatin dynamics and transcriptional programs, and blocks the self-renewal of cancer stem cells. Multi-target kinase-IN-9 induces genomic instability, lysosomal dysfunction and autophagic flux impairment, thereby triggering tumor cell death, effectively inhibiting tumor proliferation, invasion, metastasis and angiogenesis, and significantly reducing tumor volume in xenograft models. Multi-target kinase-IN-9 is applicable to hepatocellular carcinoma-related research .
Cat. No.: HY-P85551
Synonyms: CTHBP; Cytosolic thyroid hormone binding protein; Cytosolic thyroid hormone-binding protein; KPYM_HUMAN; MGC3932; OIP 3; OIP-3; OIP3; OPA interacting protein 3; Opa-interacting protein 3; p58; PK muscle type; PK, muscle type; PK2; PK3; PKM; PKM2; pykm; Pyruvate Kinase 2/3; Pyruvate Kinase 3; Pyruvate Kinase isozymes M1/M2; Pyruvate Kinase muscle; Pyruvate Kinase muscle isozyme; Pyruvate Kinase PKM; Pyruvate Kinase, muscle 2; TCB; THBP1; Thyroid hormone binding protein 1; Thyroid hormone binding protein cytosolic; Thyroid hormone-binding protein 1; Tumor M2 PK; Tumor M2-PK .
Cat. No.: HY-P85552
Synonyms: CTHBP; Cytosolic thyroid hormone binding protein; Cytosolic thyroid hormone-binding protein; KPYM_HUMAN; MGC3932; OIP 3; OIP-3; OIP3; OPA interacting protein 3; Opa-interacting protein 3; p58; PK muscle type; PK, muscle type; PK2; PK3; PKM; PKM2; pykm; Pyruvate Kinase 2/3; Pyruvate Kinase 3; Pyruvate Kinase isozymes M1/M2; Pyruvate Kinase muscle; Pyruvate Kinase muscle isozyme; Pyruvate Kinase PKM; Pyruvate Kinase, muscle 2; TCB; THBP1; Thyroid hormone binding protein 1; Thyroid hormone binding protein cytosolic; Thyroid hormone-binding protein 1; Tumor M2 PK; Tumor M2-PK.
Cat. No.: HY-12689S
Synonyms: AG-348-d8
Cat. No.: HY-P86631
Synonyms: PKM; OIP3; PK2; PK3; PKM2; Pyruvate Kinase isozymes M1/M2; Cytosolic thyroid hormone-binding protein; CTHBP; Opa-interacting protein 3; OIP-3; Pyruvate Kinase 2/3; Pyruvate Kinase muscle isozyme; Thyroid hormone-binding protein 1; THBP1; Tu
Cat. No.: HY-169659
CAS No.: 902516-53-4
Target:
Research Areas:
8-Methyl-4-oxo-N,N-dipropyl-4H-thieno[3,2-c]chromene-2-carboxamide is the drug intermediate for synthesis of pyruvate kinase inhibitor .
Cat. No.: HY-P87012
Synonyms: CTHBP antibody; Cytosolic thyroid hormone-binding protein antibody; KPYM_HUMAN antibody; OIP-3 antibody; Opa-interacting protein 3 antibody; p58 antibody; pkm antibody; PKM1 antibody; PKM2 antibody; Pyruvate Kinase 2/3 antibody; CTHBP antibody; Cytosolic thyroid hormone-binding protein antibody; KPYM_HUMAN antibody; OIP-3 antibody; Opa-interacting protein 3 antibody; p58 antibody; pkm antibody; PKM1 antibody; PKM2 antibody; Pyruvate Kinase 2/3 antibody; Pyruvate Kinase muscle isozyme antibody; Pyruvate Kinase PKM antibody; THBP1 antibody; Thyroid hormone-binding protein 1 antibody; Tumor M2-PK antibody;
Cat. No.: HY-103617R
CAS No.: 94164-88-2
Target:
Research Areas:
PKM2-IN-1 (Standard) is the analytical standard of PKM2-IN-1 (HY-103617). This product is intended for research and analytical applications. PKM2-IN-1 (compound 3k) is a pyruvate kinase M2 (PKM2) inhibitor with an IC50 of 2.95 μM .
Cat. No.: HY-P702845
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PKM; Tumor M2-PK; Prev. PKM2; P58; THBP1; Thyroid Hormone-Binding Protein, Cytosolic; OIP3; Epididymis Secretory Protein Li 30; PK3; Pyruvate Kinase Isozymes M1/M2; Pyruvate Kinase Muscle Isozyme; OPA-Interacting Protein 3; Cytosolic Thyroid Hormone-Bindi
Species:
Human
Source:
E. coli
Cat. No.: HY-110124R
CAS No.: 1221186-52-2
Target:
Research Areas:
ML202 (Standard) is the analytical standard of ML202 (HY-110124). This product is intended for research and analytical applications. ML202 is a highly specific allosteric activator of human pyruvate Kinase M2 (hPK-M2), which can affect the cooperativity of phosphoenolpyruvate (PEP) binding, while adenosine diphosphate (ADP) binding almost no effect .
Cat. No.: HY-18657R
CAS No.: 1221186-53-3
Synonyms: ML-265 (Standard)
Target:
Research Areas:
TEPP-46 (Standard) is the analytical standard of TEPP-46 (HY-18657). This product is intended for research and analytical applications. TEPP-46 (ML-265) is a potent and selective pyruvate Kinase M2 (PKM2) activator with an AC50 of 92 nM, showing little or no effect on PKM1, PKL and PKR .
Cat. No.: HY-P70599
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PKM; Tumor M2-PK; Prev. PKM2; P58; THBP1; Thyroid Hormone-Binding Protein, Cytosolic; OIP3; Epididymis Secretory Protein Li 30; PK3; Pyruvate Kinase Isozymes M1/M2; Pyruvate Kinase Muscle Isozyme; OPA-Interacting Protein 3; Cytosolic Thyroid Hormone-Bindi
Species:
Human
Source:
E. coli
Cat. No.: HY-P72053
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PKM; Tumor M2-PK; Prev. PKM2; P58; THBP1; Thyroid Hormone-Binding Protein, Cytosolic; OIP3; Epididymis Secretory Protein Li 30; PK3; Pyruvate Kinase Isozymes M1/M2; Pyruvate Kinase Muscle Isozyme; OPA-Interacting Protein 3; Cytosolic Thyroid Hormone-Bindi
Species:
Mouse
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
