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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
118 Results for "
Pyruvate Kinase
" in MedChemExpress (MCE) Product Catalog:
Products (118)
118 Results for "Pyruvate Kinase" in MCE Product Catalog:
Target:
Research Areas:
ML202 is a highly specific allosteric activator of human pyruvate kinase M2 (hPK-M2), which can affect the cooperativity of phosphoenolpyruvate (PEP) binding, while adenosine diphosphate (ADP) binding almost no effect .
Cat. No.: HY-P2806B
Target:
Research Areas:
Pyruvate Kinase, Bacillus stearothermophilus (EC 2.7.1.40) is an enzyme involved in glycolysis. Pyruvate Kinase, Bacillus stearothermophilus (EC 2.7.1.40) catalyzes the transfer of a phosphate group from phosphoenolpyruvate (PEP) to ADP, yielding one molecule of pyruvate and one molecule of ATP.
Cat. No.: HY-165154
CAS No.: 35663-85-5
Synonyms: Desdanine; Pyracrimycin A
Category:
Cat. No.: HY-146554
PDHK-IN-5 (Compound 19) is a potent inhibitor of PDHK with IC50s of 0.006 and 0.0329 μM for PDHK2 and PDHK4, repectively. Pyruvate dehydrogenase kinases (PDHKs) are fascinating agent targets for numerous diseases, including diabetes and cancers. PDHK-IN-5 has the potential for the research of cancer diseases .
Cat. No.: HY-176008
CAS No.: 2095306-47-9
Target:
Research Areas:
Lauric acid leelamide is the lauric acid (C-12) amide analog of Leelamine (HY-W005629). Leelamine exhibits inhibitory activity against pyruvate dehydrogenase kinase (PDHK) with an IC50 value of 9.5 µM. Leelamine derivatives possess anti-inflammatory effects and can inhibit phospholipase A2 activity from various sources .
Cat. No.: HY-E70953
Target:
Research Areas:
Pyruvate Kinase/Lactic Dehydrogenase enzymes, Rabbit catalyzes an ATP-dependent phosphorylation of glycolate to yield 2-phosphoglycolate. Pyruvate kinase requires bivalent and monovalent cations such as Mg 2+ and K + respectively for activation to occur.
Cat. No.: HY-179371
CAS No.: 2606032-80-6
Target:
Research Areas:
LIQ1, a flavonoid derivative, is a potent Pyruvate kinase M2 (PKM2) allosteric inhibitor (IC50 = 0.39 μM; Kd = 4.5 μM) targeting Arg43 within the polyarginine pocket. LIQ1 exhibits efficacy in a mouse model of LPS (HY-D1056)-induced endotoxemia, preventing the nuclear translocation of PKM2 and inhibiting its binding to HIF-1α, thereby suppressing IL-1β transcription. LIQ1 can be used for the research of endotoxemia [1].
Cat. No.: HY-P11948
CAS No.: 253328-16-4
Cat. No.: HY-P11948A
Cat. No.: HY-P71210
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PKLR; Pyruvate Kinase, Liver And Blood Cell; Pyruvate Kinase L/R; Pyruvate Kinase Isozymes R/L; Pyruvate Kinase, Liver And RBC; Pyruvate Kinase Isozyme R/L; Red Cell/Liver Pyruvate Kinase; Pyruvate Kinase Isoform 1; R-Type/L-Type Pyruvate Kinase; Pyruvate Kinase Type L; Pyruvate Kinase Isozymes L/R; Pyruvate Kinase; Pyruvate Kinase PKLR; CNSHA2; Pyruvate Kinase 1; PKRL; PK1; RPK; PKL
Species:
Human
Source:
HEK293
Cat. No.: HY-P700578
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PKLR; Pyruvate Kinase, Liver And Blood Cell; Pyruvate Kinase L/R; Pyruvate Kinase Isozymes R/L; Pyruvate Kinase, Liver And RBC; Pyruvate Kinase Isozyme R/L; Red Cell/Liver Pyruvate Kinase; Pyruvate Kinase Isoform 1; R-Type/L-Type Pyruvate Kinase; Pyruvate
Species:
Rat
Source:
P. pastoris
Cat. No.: HY-180523
Research Areas:
PKM2-IN-13 is a selective PKM2 inhibitor inhibiting PKM2 with an IC50 value of 55.13 μM. PKM2-IN-13 exhibits broad-spectrum anticancer activity with low toxicity to normal cells. PKM2-IN-13 induces apoptosis by elevated ROS levels and activation of caspases 3/7, and interacts with and inhibits the glycolytic activity of Pyruvate Kinase M2 in virto. PKM2-IN-13 demonstrates a favorable safety profile with no significant adverse effects in vivo. PKM2-IN-13 can be used for oral squamous cell carcinoma (OSCC), colon carcinoma, breast cancer and melanoma research .
Cat. No.: HY-P71614
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PDK3; Pyruvate Dehydrogenase, Lipoamide, Kinase Isozyme 3, Mitochondrial; Pyruvate Dehydrogenase Kinase 3; Pyruvate Dehydrogenase Kinase Isoform 3; [Pyruvate Dehydrogenase (Acetyl-Transferring)] Kinase Isozyme 3, Mitochondrial; GS1-358P8.4; Pyruvate Dehyd
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P706083
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: PDK1; Mitochondrial Pyruvate Dehydrogenase, Lipoamide, Kinase Isoenzyme 1; Pyruvate Dehydrogenase Kinase 1; Pyruvate Dehydrogenase Kinase, Isozyme 1; [Pyruvate Dehydrogenase (Acetyl-Transferring)] Kinase Isozyme 1, Mitochondrial; Pyruvate Dehydrogenase Kinase Isoform 1; Pyruvate Dehydrogenase Kinase, Isoenzyme 1; Protein-Serine/Threonine Kinase; PDH Kinase 1; PDHK1; Pyruvate Dehydrogenase (Acetyl-Transferring) Kinase Isozyme 1, Mitochondrial
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P701737
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PDK4; [Pyruvate Dehydrogenase [Lipoamide]] Kinase Isozyme 4, Mitochondrial; Pyruvate Dehydrogenase Kinase 4; Pyruvate Dehydrogenase, Lipoamide, Kinase Isozyme 4, Mitochondrial; [Pyruvate Dehydrogenase (Acetyl-Transferring)] Kinase Isozyme 4, Mitochondrial
Species:
Human
Source:
E. coli
Cat. No.: HY-P705581
Synonyms: PDK1; Mitochondrial Pyruvate Dehydrogenase, Lipoamide, Kinase Isoenzyme 1; Pyruvate Dehydrogenase Kinase 1; Pyruvate Dehydrogenase Kinase, Isozyme 1; [Pyruvate Dehydrogenase (Acetyl-Transferring)] Kinase Isozyme 1, Mitochondrial; Pyruvate Dehydrogenase Ki
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P83644
Synonyms: PKM2 (Phospho Tyr105); PKM2 (Phospho Y105); PK 1; PK 2; PK 3; PK Muscle type; PK1; PK2; Pk3; PKL; PKLR; PKM 2; PKM; PYKM; Pyruvate Kinase 1; Pyruvate Kinase 2/3; Pyruvate Kinase 3; Pyruvate Kinase isozyme R/L; Pyruvate Kinase isozymes M1/M2; Pyruvate Kinase liver and blood cell; Pyruvate Kinase liver and RBC; Pyruvate Kinase liver and RBC type; Pyruvate Kinase M2; Pyruvate Kinase muscle; Pyruvate Kinase muscle isozyme; Pyruvate Kinase type L; R type/L type Pyruvate Kinase; Red cell/liver Pyruvate Kinase; RPK; TCB; THBP 1; THBP1; Thyroid hormone binding protein cytosolic; CTHBP; Cytosolic thyroid hormone binding protein; MGC3932; OIP 3; Oip3; Tumor M2-PK; p58; OIP-3.
Cat. No.: HY-P74639
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: PDK4; [Pyruvate Dehydrogenase [Lipoamide]] Kinase Isozyme 4, Mitochondrial; Pyruvate Dehydrogenase Kinase 4; Pyruvate Dehydrogenase, Lipoamide, Kinase Isozyme 4, Mitochondrial; [Pyruvate Dehydrogenase (Acetyl-Transferring)] Kinase Isozyme 4, Mitochondrial
Species:
Mouse
Source:
Sf9 insect cells
Cat. No.: HY-P704056
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PDK4; [Pyruvate Dehydrogenase [Lipoamide]] Kinase Isozyme 4, Mitochondrial; Pyruvate Dehydrogenase Kinase 4; Pyruvate Dehydrogenase, Lipoamide, Kinase Isozyme 4, Mitochondrial; [Pyruvate Dehydrogenase (Acetyl-Transferring)] Kinase Isozyme 4, Mitochondrial
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
