2095306-47-9
2095306-47-9
Chemical Structure
Lauric acid leelamide
- CAS No.: 2095306-47-9
- Formula:C32H53NO
- Molecular Weight:467.77
SMILES: CC(C1=CC2=C([C@@]3([C@]([H])([C@](CNC(CCCCCCCCCCC)=O)(CCC3)C)CC2)C)C=C1)C
Biological Activity: Lauric acid leelamide is the lauric acid (C-12) amide analog of Leelamine (HY-W005629). Leelamine exhibits inhibitory activity against pyruvate dehydrogenase kinase (PDHK) with an IC50 value of 9.5 µM. Leelamine derivatives possess anti-inflammatory effects and can inhibit phospholipase A2 activity from various sources[1][2].
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Lauric acid leelamide | Lauric acid leelamide is the lauric acid (C-12) amide analog of Leelamine (HY-W005629). Leelamine exhibits inhibitory activity against pyruvate dehydrogenase kinase (PDHK) with an IC50 value of 9.5 µM. Leelamine derivatives possess anti-inflammatory effects and can inhibit phospholipase A2 activity from various sources. | |||||||||||||||||||||
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References
- [1]. Aicher TD, et al. Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK). Bioorg Med Chem Lett. 1999 Aug 2;9(15):2223-8. [Content Brief]
- [2]. Wilkerson W, et al. Antiinflammatory phospholipase-A2 inhibitors. I[J]. European journal of medicinal chemistry, 1991, 26(7): 667-676.
