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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
117 Results for "
Pyruvate Kinase
" in MedChemExpress (MCE) Product Catalog:
Products (117)
117 Results for "Pyruvate Kinase" in MCE Product Catalog:
Synonyms: (Rac)-FT-4202
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(Rac)-Etavopivat ((Rac)-FT-4202) is an isomer of Etavopivat (HY-139573). Etavopivat is an orally active erythrocyte pyruvate kinase-R (PKR) activator that can be used in studies of sickle cell disease and other haemoglobinopathies .
Cat. No.: HY-W134163
CAS No.: 2548-87-0
Synonyms: trans-2-Octenal
Cat. No.: HY-153354
CAS No.: 2283420-05-1
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PKR activator 4 (example 7A) is a potent pyruvate kinase R (PKR) activator. PKR activator 4 has the potential for the research of blood disorders .
Cat. No.: HY-157538
CAS No.: 1616752-12-5
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PDK4-IN-2 (compound 8) is a pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 of 46 µM. PDK4-IN-2 improves ejection fraction of failing hearts by regulating bioenergetics via activation of the tricarboxylic acid cycle .
Cat. No.: HY-126585S
Cat. No.: HY-178748
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PKM2-IN-12 is an orally active PKM2 inhibitor with an IC50 of 10 nM. PKM2-IN-12 inhibits COLO-205 cell proliferation and migration, arrests the cell cycle, and induces apoptosis. PKM2-IN-12 significantly reduces cellular levels of lactate, pyruvate, and ROS. PKM2-IN-12 directly kills cancer cells and restores disrupted gut microbiota balance in mice model. PKM2-IN-12 can be used to study colorectal cancer .
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2,5-Anhydro-D-glucitol-1,6-diphosphate is a competitive PFK-1 inhibitor. 2,5-Anhydro-D-glucitol-1,6-diphosphate inhibits the enzymatic activity of PFKP without altering the non-glycolytic regulatory function of PFKP. 2,5-Anhydro-D-glucitol-1,6-diphosphate does not change mitochondrial AMPK levels, ACC2 phosphorylation levels, long-chain free fatty acid levels, or ROS levels under glucose starvation conditions. 2,5-Anhydro-D-glucitol-1,6-diphosphate is used in related research on non-small cell lung cancer .
Cat. No.: HY-170577
CAS No.: 3115004-02-6
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PKM2-IN-8 (Compound 9b) is a pyruvate kinase M2 (PKM2) inhibitor (IC50 = 0.31 μM). PKM2-IN-8 has potent antiproliferative activity against U87MG glioma cells. PKM2-IN-8 can induce early apoptosis and reduce lactate levels. PKM2-IN-8 can be used for the research of glioblastoma .
Cat. No.: HY-168446
CAS No.: 3057531-75-3
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PKR-IN-1 (Compound 5s) is a pyruvate kinase (PK) inhibitor that has antifungal activity, with an EC50 of 0.21 μg/mL for R. solani .
Cat. No.: HY-12689C
CAS No.: 2559738-69-9
Synonyms: AG-348 hydrochloride
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Mitapivat (AG-348) hydrochloride is an orally active and selective allosteric pyruvate kinase R (PK-R) activator. Mitapivat hydrochloride accelerates the reaction of PK-R catalyzing the conversion of phosphoenolpyruvate to pyruvate, thereby promoting the glycolytic pathway, increasing the production of adenosine triphosphate (ATP) in red blood cells, and reducing the level of 2,3-diphosphoglycerate (2,3-DPG). Mitapivat hydrochloride is promising for research of pyruvate kinase deficiency and other anemia-related diseases .
Cat. No.: HY-12689B
CAS No.: 2329710-91-8
Synonyms: AG-348 hemisulfate
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Mitapivat hemisulfate is an orally active pyruvate kinase allosteric activator. Mitapivat hemisulfate increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes, shows the potential to restore the activity of PK (pyruvate kinase)-deficient glycolytic pathways. Mitapivat hemisulfate can be used in study of PK deficiency .
Cat. No.: HY-12689A
CAS No.: 2151847-10-6
Synonyms: AG-348 hemisulfate sesquihydrate
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Mitapivat hemisulfate sesquihydrate (AG-348) is an orally active pyruvate kinase allosteric activator. Mitapivat increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes, shows the potential to restore the activity of PK (pyruvate kinase)-deficient glycolytic pathways. Mitapivat can be used in study of PK deficiency .
Synonyms: 5'-p-Fluorosulfonylbenzoyladenosine
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FSBA (5'-p-Fluorosulfonylbenzoyladenosine) hydrochloride is a covalent modifier and affinity labeling reagent for adenine nucleotide-binding proteins. FSBA hydrochloride covalently attaches to the nucleotide-binding sites of pyruvate kinase, glutamate dehydrogenase, and p56 lck, and to a lysine residue in the ATP-binding site of cAMP-dependent protein kinase, causing loss of enzymatic activity. FSBA hydrochloride can be used for the research of T lymphoma .
Cat. No.: HY-159095
CAS No.: 2761226-35-9
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PKR activator 5 (Compound 18) is an activator for pyruvate kinase R (PKR) with an AC50 of 28 nM .
Cat. No.: HY-162071
CAS No.: 904457-46-1
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PKM2-IN-5 (Compound G1) is an inhibitor for pyruvate kinase M2 (PKM2), with IC50 >70 μM .
Cat. No.: HY-135883
CAS No.: 2283420-62-0
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PKR activator 1 is a potent pyruvate kinase-R (PKR) activator extracted from patent WO2019035865A1, compound E7-93 .
Cat. No.: HY-173581
CAS No.: 2841710-23-2
Arachidonic acid leelamide, a Leelamine (HY-W005629) analog, is a pyruvate dehydrogenase kinase (PDK) inhibitor. Arachidonic acid leelamide can be used for the study of breast cancer .
Cat. No.: HY-N6663R
CAS No.: 13466-78-9
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
