2151847-10-6
Chemical Structure
Mitapivat hemisulfate sesquihydrate
Synonym(s): AG-348 hemisulfate sesquihydrate
- CAS No.: 2151847-10-6
- Formula:C24H26N4O3S.1/2H2SO4.3/2H2O
- Molecular Weight:526.62
SMILES: O=C(N1CCN(CC2CC2)CC1)C3=CC=C(NS(=O)(C4=CC=CC5=CC=CN=C54)=O)C=C3.O=S(O)(O)=O.O.[0.5].[1.5]
Biological Activity: Mitapivat hemisulfate sesquihydrate (AG-348) is an orally active pyruvate kinase allosteric activator. Mitapivat increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes, shows the potential to restore the activity of PK (pyruvate kinase)-deficient glycolytic pathways. Mitapivat can be used in study of PK deficiency[1][2][3].
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Mitapivat hemisulfate sesquihydrate | Mitapivat hemisulfate sesquihydrate (AG-348) is an orally active pyruvate kinase allosteric activator. Mitapivat increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes, shows the potential to restore the activity of PK (pyruvate kinase)-deficient glycolytic pathways. Mitapivat can be used in study of PK deficiency. | |||||||||||||||||||||
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- [1]. Kung C, et al. AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency. Blood. 2017 Sep 14;130(11):1347-1356. [Content Brief]
- [2]. Matte A, et al. The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model. J Clin Invest. 2021 May 17;131(10):e144206. [Content Brief]
- [3]. Rab MAE, et al. AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes. Haematologica. 2021 Jan 1;106(1):238-249. [Content Brief]
Keywords
