78859-42-4
Chemical Structure
FSBA hydrochloride
Synonym(s): 5'-p-Fluorosulfonylbenzoyladenosine
- CAS No.: 78859-42-4
- Formula:C17H17ClFN5O7S
- Molecular Weight:489.86
IUPAC Name: ((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl 4-(fluorosulfonyl)benzoate hydrochloride
InChIKey: ZUHVYHQVJYIHPN-KHXPSBENSA-N
SMILES: NC1=C(C2=NC=N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)COC(C4=CC=C(C=C4)S(=O)(F)=O)=O)O)O.Cl
Biological Activity: FSBA (5'-p-Fluorosulfonylbenzoyladenosine) hydrochloride is a covalent modifier and affinity labeling reagent for adenine nucleotide-binding proteins. FSBA hydrochloride covalently attaches to the nucleotide-binding sites of pyruvate kinase, glutamate dehydrogenase, and p56lck, and to a lysine residue in the ATP-binding site of cAMP-dependent protein kinase, causing loss of enzymatic activity. FSBA hydrochloride can be used for the research of T lymphoma[1][2].
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FSBA hydrochloride | 99.06% | FSBA (5'-p-Fluorosulfonylbenzoyladenosine) hydrochloride is a covalent modifier and affinity labeling reagent for adenine nucleotide-binding proteins. FSBA hydrochloride covalently attaches to the nucleotide-binding sites of pyruvate kinase, glutamate dehydrogenase, and p56lck, and to a lysine residue in the ATP-binding site of cAMP-dependent protein kinase, causing loss of enzymatic activity. FSBA hydrochloride can be used for the research of T lymphoma. | ||||||||||||||||||||
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- [1]. Anostario M Jr, et al. Immunochemical detection of adenine nucleotide-binding proteins with antibodies to 5'-p-fluorosulfonylbenzoyladenosine. Anal Biochem. 1990 Oct;190(1):60-5. [Content Brief]
- [2]. Ramaswamy S, et al. Nucleotide binding to the C-terminal nucleotide binding domain of ArsA. Studies with an ATP analogue, 5'-p-fluorosulfonylbenzoyladenosine. J Biol Chem. 1998 Apr 10;273(15):9243-8. [Content Brief]
Keywords
