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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
150 Results for "
LP
" in MedChemExpress (MCE) Product Catalog:
Products (150)
150 Results for "LP" in MCE Product Catalog:
Cat. No.: HY-160581
CAS No.: 496801-51-5
OH-C-Chol is a cationic liposome that serves as a siRNA delivery vehicle. OH-C-Chol (LP-C) and OH-NC-Chol (LP-NC)/siRNA complexes (lipoplexes) showed better performance than NP-C and NP-NC/siRNA complexes (nanocomplexes), respectively. ) greater gene silencing effect .
Cat. No.: HY-19415A
CAS No.: 304694-41-5
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SB-435495 hydrochloride is a potent, selective, reversible, non-covalent and orally active Lp-PLA2 inhibitor with an IC50 of 0.06 nM .
Cat. No.: HY-169114
CAS No.: 412950-27-7
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Goxalapladib is a 5-HT6 receptor modulator that blocks lipoprotein-associated phospholipase A2 (Lp-PLA2) activity. Goxalapladib is promising for research of atherosclerosis-associated cardiovascular diseases .
Cat. No.: HY-179611
LP-03 is an antibacterial agent with selective activity against Methicillin-resistant Staphylococcus aureus (MRSA). Its minimum inhibitory concentration (MIC) is 6.2 μM. LP-03 has an inhibitory effect on biofilm formation, but it is unable to effectively remove the formed biofilms. LP-03 can enhance membrane permeability, disrupt the membrane structure of MRSA cells, and does not cause significant membrane depolarization. LP-03 has no hemolytic toxicity and shows low mammalian cell toxicity. It can be used for research on MRSA infections .
Cat. No.: HY-182632
CAS No.: 1875037-24-3
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LP-935001 is a Notum carboxylesterase inhibitor with an IC50 of 0.4 nM.LP-935001 prevents palmitoleate group removal from Wnt proteins, restores Wnt/β-catenin signaling.LP-935001 enhances cortical bone thickness in rodent models.LP-935001 can be used for the research of bone loss/nonvertebral fractures .
Cat. No.: HY-111455R
CAS No.: 1052147-86-0
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LP-211 (Standard) is the analytical standard of LP-211 (HY-111455). This product is intended for research and analytical applications. LP-211 is a selective and blood brain barrier penetrant 5-HT7 receptor agonist, with a Ki of 0.58 nM, with high selectivity over 5-HT1A receptor (Ki, 188 nM) and D2 receptor (Ki, 142 nM).
Cat. No.: HY-180474
CAS No.: 3024403-65-1
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LP293-p is a lipid with activated ester groups, which can be used for the synthesis of ATXN2 RNAi. LP293-p can be utilized to enhance the targeting of the central nervous system (CNS) .
Cat. No.: HY-186095
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LP-911888 is an orally active ACSL5/ACSL1 inhibitor, with IC50 values of 1 nM and 3 nM against mouse and human ACSL5, and IC50 values of 2 nM and 9 nM against mouse and human ACSL1, respectively. LP-911888 inhibits intestinal triglyceride uptake; it also reduces body weight and food consumption in diet-induced obese mice, and delays gastric emptying by activating the ileal brake pathway. LP-911888 can be used in studies of diet-induced obesity .
Cat. No.: HY-103101R
CAS No.: 824958-12-5
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LP44 hydrochloride (Standard) is the analytical standard of LP44 hydrochloride (HY-103101). This product is intended for research and analytical applications. LP44 hydrochloride is a selective 5-HT7 agonist with Ki of 0.22 nM. LP44 hydrochloride induces hypothermic effect in a dose-dependent manner by intracerebroventricular injection. LP44 hydrochloride not causes considerable hypothermic response by intraperitoneal administration .
Cat. No.: HY-403699
CAS No.: 3049664-89-0
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LP-371-p is a lipid that can specifically and efficiently deliver oligonucleotide compounds to the fat tissues in the body (especially fat cells). LP-371-p can be used in research on diseases related to fat, such as obesity and type 2 diabetes .
Cat. No.: HY-186096
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LP-856866 is an orally active ACSL5 inhibitor, with IC50 values of 8 nM and 4 nM against mouse and human ACSL5, respectively, and IC50 values of 6 nM and 17 nM against mouse and human ACSL1, respectively. LP-856866 induces delayed gastric emptying, promotes GLP-1 release, reduces food intake, decreases body weight and body fat mass, preserves lean body mass, improves glucose homeostasis, enhances insulin sensitivity, reduces hepatic lipid accumulation, and lowers serum triglyceride and total cholesterol levels. LP-856866 is applicable to research on diet-induced obesity .
Cat. No.: HY-P992183
Cat. No.: HY-180115
LP07 is an antibacterial agent targeting Pseudomonas aeruginosa with MIC values for both wild-type and efflux pump-deficient P. aeruginosa PA14 of both 8 μg/mL. LP07 exerts its antibacterial effect by directly disrupting the structural integrity of the bacterial cell membrane. LP07 moderately inhibits MMP-17 and MMP-19, but has no significant inhibitory effect on other MMP subtypes. LP07 does not inhibit the activity of LpxC enzyme. LP07 can be used for research on Pseudomonas aeruginosa infections .
Cat. No.: HY-RS19778
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Hapln1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hapln1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-171728
CAS No.: 3049664-45-8
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Azide-PEG2-amide-C14-COOH (Compound LP-379-p) is a lipid-containing compound. Azide-PEG2-amide-C14-COOH facilitates the delivery of oligonucleotide-based reagents to certain cell types or adipose tissue .
Cat. No.: HY-185932
CAS No.: 2959546-45-1
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Tisbesiran is an apolipoprotein(a) (apo(a)) synthesis inhibitor. Tisbesiran is a trivalent GalNAc-conjugated double-stranded siRNA with a mixed modification of 2′-OMe/2′-F/P-thio. Its antisense strand targets the KIV-2 repeat region of human apo(a) (LPA) mRNA, thereby inhibiting apolipoprotein(a) synthesis and reducing plasma Lp(a). Tisbesiran can be used for research on Lp(a)-mediated atherosclerotic cardiovascular disease .
Cat. No.: HY-P77066
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LPAL2; Apolipoprotein A-Related Gene C Protein; Prev. APOAL; Lipoprotein, LP(A)-Like 2; APOARGC; Apolipoprotein A-Like; Lipoprotein, LP(A)-Like 2, Pseudogene; LP(A)-Liker Protein 2; Apo(A)Rg-C; Apo(A)-Like Protein 2; Putative Apolipoprotein(A)-Like Protei
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
