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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
123 Results for "
SAM
" in MedChemExpress (MCE) Product Catalog:
Products (123)
123 Results for "SAM" in MCE Product Catalog:
Cat. No.: HY-W753201
Synonyms: 5'-(Methylthio)-5'-deoxyadenosine-13C; 5'-Deoxy-5'-(methylthio)adenosine-13C; 5'-S-Methyl-5'-thioadenosine-13C
Cat. No.: HY-143467
CAS No.: 2445585-37-3
SARS-CoV-IN-4 (compound 13) is a potent and specific inhibitor of SARS-CoV nsp14 N7-methyltransferase, with an IC50 of 0.6 μM (SARS-CoV nsp14) .
Cat. No.: HY-170524
CAS No.: 3052313-73-9
Research Areas:
TDI-015051 is a highly selective, orally active antiviral agent that targets the coronavirus NSP14 guanine-N7 methyltransferase. TDI-015051 binds to substrates in a non-competitive manner and forms a stable ternary complex, precisely blocking the capping and methylation processes of viral mRNA. TDI-015051 potently inhibits a variety of coronaviruses (including SARS-CoV-2 and MERS). By impairing viral replication and translation and inducing a moderate type I interferon-mediated immune response, it significantly reduces pulmonary viral load and exhibits a synergistic effect with Nirmatrelvir (HY-138687). In addition, TDI-015051 does not inhibit non-coronavirus methyltransferases, and the drug-resistant mutations it induces impair viral fitness, demonstrating excellent antiviral properties and safety. TDI-015051 can be used for research on COVID-19 and the replication mechanism of coronaviruses .The IC50 values of TDI-015051 against SARS-CoV-2, α-hCoV-NL63, α-hCoV-229E, β-hCoV-MERS are 0.15 nM, 1.7 nM, 2.6 nM and 3.6 nM, respectively, and the Ka value against SARS-CoV-2 is 0.061 nM .
Cat. No.: HY-155051
Target:
Research Areas:
Antiproliferative agent-25 (Compound 3s4) is a selective PRMT5 inhibitor (IC50: 0.11 μM). Antiproliferative agent-25 up-regulates hnRNP E1 protein level. Antiproliferative agent-25 forms H-bond interactions with SAM and E444 residue of PRMT5. Antiproliferative agent-25 has antiproliferative effects against A549 cells by inducing apoptosis and inhibiting cell migration. Antiproliferative agent-25 has high clearances with T1/2 of only 21.8 and 4.7 min in human and rat liver microsomes .
Cat. No.: HY-16938S2
Synonyms: 5'-(Methylthio)-5'-deoxyadenosine-13C5; 5'-Deoxy-5'-(methylthio)adenosine-13C5; 5'-S-Methyl-5'-thioadenosine-13C5
Cat. No.: HY-170906S
CAS No.: 2925324-58-7
Cat. No.: HY-P85167
Synonyms: FGFR1; BFGFR; CEK; FGFBR; FLG; FLT2; HBGFR; Fibroblast growth factor receptor 1; FGFR-1; Basic fibroblast growth factor receptor 1; BFGFR; bFGF-R-1; Fms-like tyrosine kinase 2; FLT-2; N-SAM; Proto-oncogene c-Fgr; CD antigen CD331
Cat. No.: HY-P86634
Synonyms: FGFR1; BFGFR; CEK; FGFBR; FLG; FLT2; HBGFR; Fibroblast growth factor receptor 1; FGFR-1; Basic fibroblast growth factor receptor 1; BFGFR; bFGF-R-1; Fms-like tyrosine kinase 2; FLT-2; N-SAM; Proto-oncogene c-Fgr; CD antigen CD331
Cat. No.: HY-P702882
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SARM1; Sterile Alpha And Armadillo Repeat Protein; Sterile Alpha And TIR Motif Containing 1; SAM Domain-Containing Protein 2; SAMD2; Tir-1 Homolog; SARM; NADase SARM1; Sterile Alpha And TIR Motif-Containing Protein 1; MyD88-5; NADP(+) Hydrolase SARM1; HSA
Species:
Human
Source:
HEK293
Cat. No.: HY-P705957
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SARM1; Sterile Alpha And Armadillo Repeat Protein; Sterile Alpha And TIR Motif Containing 1; SAM Domain-Containing Protein 2; SAMD2; Tir-1 Homolog; SARM; NADase SARM1; Sterile Alpha And TIR Motif-Containing Protein 1; MyD88-5; NADP(+) Hydrolase SARM1; HSA
Species:
Human
Source:
HEK293
Cat. No.: HY-179556
SARS-CoV-2 nsp14-IN-10 is a highly potent and selective NSP14 (IC50 = 0.34 µM) S-adenosylmethionine (SAM) binding pocket inhibitor. SARS-CoV-2 nsp14-IN-10 demonstrates robust antiviral activity against SARS-CoV-2. SARS-CoV-2 nsp14-IN-10 exhibits broad-spectrum activity against other betacoronaviruses and inhibits SARS-CoV-2 at the replication stage. SARS-CoV-2 nsp14-IN-10 suppresses viral translation and exhibits immunostimulatory effects. SARS-CoV-2 nsp14-IN-10 specifically reverses NSP14-mediated alterations inhost transcriptome. SARS-CoV-2 nsp14-IN-10 can be used for the study of SARS-CoV-2 .
Cat. No.: HY-P705472
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: Fibroblast growth factor receptor 1; EC:2.7.10.1; FGFR-1; Basic fibroblast growth factor receptor 1; BFGFR; bFGF-R-1; Fms-like tyrosine kinase 2; FLT-2; N-SAM; CD331; FGFR1; BFGFR, CEK, FGFBR; FLG; FLT2; HBGFR
Species:
Human
Source:
HEK293
Cat. No.: HY-P76333
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: FGFR2; Protein Tyrosine Kinase, Receptor Like 14; Prev. KGFR; Fibroblast Growth Factor Receptor; Prev. BEK; Receptor Protein-Tyrosine Kinase; Prev. CFD1; Craniofacial Dysostosis 1; Prev. JWS; Alternative Protein FGFR2; Keratinocyte Growth Factor Receptor; Soluble FGFR2 Variant 3; K-SAM; Jackson-Weiss Syndrome; CD332; Pfeiffer Syndrome; CEK3; Crouzon Syndrome; TK14; CD332 Antigen; TK25; FGFR-2; ECT1; BFR-1; Bacteria-Expressed Kinase; K-SAM; Fibroblast Growth Factor Receptor 2 KSAM IV Secreted Isoform; BBDS; Fibroblast Growth Factor Receptor 2 Isoform IgIIIb Isoform; KSAM; Fibroblast Growth Factor Receptor 2 Isoform IgIIIc Isoform; Fibroblast Growth Factor Receptor 2; BEK Fibroblast Growth Factor Receptor
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P706045
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: FGFR2; Protein Tyrosine Kinase, Receptor Like 14; Prev. KGFR; Fibroblast Growth Factor Receptor; Prev. BEK; Receptor Protein-Tyrosine Kinase; Prev. CFD1; Craniofacial Dysostosis 1; Prev. JWS; Alternative Protein FGFR2; Keratinocyte Growth Factor Receptor; Soluble FGFR2 Variant 3; K-SAM; Jackson-Weiss Syndrome; CD332; Pfeiffer Syndrome; CEK3; Crouzon Syndrome; TK14; CD332 Antigen; TK25; FGFR-2; ECT1; BFR-1; Bacteria-Expressed Kinase; K-SAM; Fibroblast Growth Factor Receptor 2 KSAM IV Secreted Isoform; BBDS; Fibroblast Growth Factor Receptor 2 Isoform IgIIIb Isoform; KSAM; Fibroblast Growth Factor Receptor 2 Isoform IgIIIc Isoform; Fibroblast Growth Factor Receptor 2; BEK Fibroblast Growth Factor Receptor
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P706046
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: FGFR2; Protein Tyrosine Kinase, Receptor Like 14; Prev. KGFR; Fibroblast Growth Factor Receptor; Prev. BEK; Receptor Protein-Tyrosine Kinase; Prev. CFD1; Craniofacial Dysostosis 1; Prev. JWS; Alternative Protein FGFR2; Keratinocyte Growth Factor Receptor; Soluble FGFR2 Variant 3; K-SAM; Jackson-Weiss Syndrome; CD332; Pfeiffer Syndrome; CEK3; Crouzon Syndrome; TK14; CD332 Antigen; TK25; FGFR-2; ECT1; BFR-1; Bacteria-Expressed Kinase; K-SAM; Fibroblast Growth Factor Receptor 2 KSAM IV Secreted Isoform; BBDS; Fibroblast Growth Factor Receptor 2 Isoform IgIIIb Isoform; KSAM; Fibroblast Growth Factor Receptor 2 Isoform IgIIIc Isoform; Fibroblast Growth Factor Receptor 2; BEK Fibroblast Growth Factor Receptor
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P706047
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: FGFR2; Protein Tyrosine Kinase, Receptor Like 14; Prev. KGFR; Fibroblast Growth Factor Receptor; Prev. BEK; Receptor Protein-Tyrosine Kinase; Prev. CFD1; Craniofacial Dysostosis 1; Prev. JWS; Alternative Protein FGFR2; Keratinocyte Growth Factor Receptor; Soluble FGFR2 Variant 3; K-SAM; Jackson-Weiss Syndrome; CD332; Pfeiffer Syndrome; CEK3; Crouzon Syndrome; TK14; CD332 Antigen; TK25; FGFR-2; ECT1; BFR-1; Bacteria-Expressed Kinase; K-SAM; Fibroblast Growth Factor Receptor 2 KSAM IV Secreted Isoform; BBDS; Fibroblast Growth Factor Receptor 2 Isoform IgIIIb Isoform; KSAM; Fibroblast Growth Factor Receptor 2 Isoform IgIIIc Isoform; Fibroblast Growth Factor Receptor 2; BEK Fibroblast Growth Factor Receptor
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P706048
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: FGFR2; Protein Tyrosine Kinase, Receptor Like 14; Prev. KGFR; Fibroblast Growth Factor Receptor; Prev. BEK; Receptor Protein-Tyrosine Kinase; Prev. CFD1; Craniofacial Dysostosis 1; Prev. JWS; Alternative Protein FGFR2; Keratinocyte Growth Factor Receptor; Soluble FGFR2 Variant 3; K-SAM; Jackson-Weiss Syndrome; CD332; Pfeiffer Syndrome; CEK3; Crouzon Syndrome; TK14; CD332 Antigen; TK25; FGFR-2; ECT1; BFR-1; Bacteria-Expressed Kinase; K-SAM; Fibroblast Growth Factor Receptor 2 KSAM IV Secreted Isoform; BBDS; Fibroblast Growth Factor Receptor 2 Isoform IgIIIb Isoform; KSAM; Fibroblast Growth Factor Receptor 2 Isoform IgIIIc Isoform; Fibroblast Growth Factor Receptor 2; BEK Fibroblast Growth Factor Receptor
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P706049
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: FGFR2; Protein Tyrosine Kinase, Receptor Like 14; Prev. KGFR; Fibroblast Growth Factor Receptor; Prev. BEK; Receptor Protein-Tyrosine Kinase; Prev. CFD1; Craniofacial Dysostosis 1; Prev. JWS; Alternative Protein FGFR2; Keratinocyte Growth Factor Receptor; Soluble FGFR2 Variant 3; K-SAM; Jackson-Weiss Syndrome; CD332; Pfeiffer Syndrome; CEK3; Crouzon Syndrome; TK14; CD332 Antigen; TK25; FGFR-2; ECT1; BFR-1; Bacteria-Expressed Kinase; K-SAM; Fibroblast Growth Factor Receptor 2 KSAM IV Secreted Isoform; BBDS; Fibroblast Growth Factor Receptor 2 Isoform IgIIIb Isoform; KSAM; Fibroblast Growth Factor Receptor 2 Isoform IgIIIc Isoform; Fibroblast Growth Factor Receptor 2; BEK Fibroblast Growth Factor Receptor
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
